1,3-Oxazines as BACE1 and/or BACE2 inhibitors: a patent evaluation (WO2012156284).

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BACE2 suppression promotes β-cell survival and function in a model of type 2 diabetes induced by human islet amyloid polypeptide overexpression.

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1,3-Oxazines as BACE1 and/or BACE2 inhibitors: a patent evaluation (WO2012156284).

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1,3-Oxazines as BACE1 and/or BACE2 inhibitors: a patent evaluation (WO2012156284).

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Eric J Gilbert

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Discovery of an Orally Available, Brain Penetrant BACE1 Inhibitor That Affords Robust CNS Aβ Reduction

β-Secretase (BACE1) inhibitors with high in vivo efficacy suitable for clinical evaluation in Alzheimer's disease

Alzheimer's disease: the amyloid cascade hypothesis

A beta oligomers - a decade of discovery

Amyloid deposition as the central event in the aetiology of Alzheimer's disease

The case described by Alois Alzheimer in 1911. Historical and conceptual perspectives based on the clinical record and neurohistological sections.

The secretases: enzymes with therapeutic potential in Alzheimer disease.

Alzheimer's disease: strategies for disease modification.

BACE inhibitors as potential drugs for the treatment of Alzheimer's disease: focus on bioactivity.

Small-molecule BACE1 inhibitors: a patent literature review (2006 - 2011).

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1069-1073

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scholarly article

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10.1517/13543776.2013.818134

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English

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2013-07-10T00:00:00Z

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1,3-Oxazines as BACE1 and/or BACE2 inhibitors: a patent evaluation (WO2012156284).

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P2860

1,3-Oxazines as BACE1 and/or BACE2 inhibitors: a patent evaluation (WO2012156284).

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