Edgotype: a fundamental link between genotype and phenotype.
about
Forward Individualized Medicine from Personal Genomes to InteractomesFundamentals of protein interaction network mappingCommunity structure analysis of transcriptional networks reveals distinct molecular pathways for early- and late-onset temporal lobe epilepsy with childhood febrile seizuresApplications of comparative evolution to human disease geneticsAnalysis of individual protein regions provides novel insights on cancer pharmacogenomicsA Pan-Cancer Catalogue of Cancer Driver Protein Interaction InterfacesThe last enzyme of the de novo purine synthesis pathway 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) plays a central role in insulin signaling and the Golgi/endosomes protein networkHand/foot splitting and the 're-evolution' of mesopodial skeletal elements during the evolution and radiation of chameleonsWidespread macromolecular interaction perturbations in human genetic disordersViewing protein fitness landscapes through a next-gen lens.A Split-Ubiquitin Based Strategy Selecting for Protein Complex-Interfering MutationsSystematic exploration of ubiquitin sequence, E1 activation efficiency, and experimental fitness in yeastIdentifying network-based biomarkers of complex diseases from high-throughput data.Systems biology and the analysis of genetic variation.Assemblages: functional units formed by cellular phase separationProtein domain-level landscape of cancer-type-specific somatic mutations.Genetic perturbations that impair functional trait interactions lead to reduced bone strength and increased fragility in mice.Tumor characterization and stratification by integrated molecular profiles reveals essential pan-cancer features.Unravelling personalized dysfunctional gene network of complex diseases based on differential network modelBig-data-based edge biomarkers: study on dynamical drug sensitivity and resistance in individuals.Protein-protein interactions as drug targets.Quantitative interactome analysis reveals a chemoresistant edgotype.Genome and network visualization facilitates the analyses of the effects of drugs and mutations on protein-protein and drug-protein networks.PCAN: phenotype consensus analysis to support disease-gene association.Modular transcriptional repertoire and MicroRNA target analyses characterize genomic dysregulation in the thymus of Down syndrome infants.The cancer cell map initiative: defining the hallmark networks of cancer.Genetics of Combined Pituitary Hormone Deficiency: Roadmap into the Genome Era.MSX1 mutations and associated disease phenotypes: genotype-phenotype relations.Annexin A2 is SUMOylated on its N-terminal domain: regulation by insulin.Functional variomics and network perturbation: connecting genotype to phenotype in cancer.PPIXpress: construction of condition-specific protein interaction networks based on transcript expression.Diagnosing phenotypes of single-sample individuals by edge biomarkers.Reasoning over genetic variance information in cause-and-effect models of neurodegenerative diseasesComputer-aided biomarker discovery for precision medicine: data resources, models and applications.A systematic atlas of chaperome deregulation topologies across the human cancer landscape.Extended linkers improve the detection of PPIs by DHFR PCA in living cells.Base-resolution stratification of cancer mutations using functional variomics.dSysMap: exploring the edgetic role of disease mutations.Identification of novel diagnostic biomarkers for thyroid carcinoma.Systematic Functional Annotation of Somatic Mutations in Cancer.
P2860
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P2860
Edgotype: a fundamental link between genotype and phenotype.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年学术文章
@wuu
2013年学术文章
@zh-cn
2013年学术文章
@zh-hans
2013年学术文章
@zh-my
2013年学术文章
@zh-sg
2013年學術文章
@yue
2013年學術文章
@zh
2013年學術文章
@zh-hant
name
Edgotype: a fundamental link between genotype and phenotype.
@en
type
label
Edgotype: a fundamental link between genotype and phenotype.
@en
prefLabel
Edgotype: a fundamental link between genotype and phenotype.
@en
P2093
P2860
P1476
Edgotype: a fundamental link between genotype and phenotype.
@en
P2093
Benoit Charloteaux
Marc Vidal
Michael E Cusick
Nidhi Sahni
Noor Jailkhani
Quan Zhong
P2860
P304
P356
10.1016/J.GDE.2013.11.002
P577
2013-11-26T00:00:00Z