Therapeutical approaches under investigation for treatment of Chagas disease. - Test2 - elhamkhani - TriplyDB

Therapeutical approaches under investigation for treatment of Chagas disease.

Therapeutical approaches under investigation for treatment of Chagas disease.

http://www.wikidata.org/entity/Q38214136

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Benznidazole/Itraconazole Combination Treatment Enhances Anti-Trypanosoma cruzi Activity in Experimental Chagas Disease Validation of N-myristoyltransferase as Potential Chemotherapeutic Target in Mammal-Dwelling Stages of Trypanosoma cruzi LAMP-2 absence interferes with plasma membrane repair and decreases T. cruzi host cell invasion Efficacy of Lychnopholide Polymeric Nanocapsules after Oral and Intravenous Administration in Murine Experimental Chagas Disease Molecular modeling and structure-activity relationships for a series of benzimidazole derivatives as cruzain inhibitors.Nitrotriazole-Based Compounds as Antichagasic Agents in a Long-Treatment In Vivo Assay.Increased Body Exposure to New Anti-Trypanosomal Through Nanoencapsulation.Preparation of benznidazole pellets for immediate drug delivery using the extrusion spheronization technique.Hydroxamic acid derivatives: a promising scaffold for rational compound optimization in Chagas disease.4-aminopyridyl-based lead compounds targeting CYP51 prevent spontaneous parasite relapse in a chronic model and improve cardiac pathology in an acute model of Trypanosoma cruzi infection.Looking for combination of benznidazole and Trypanosoma cruzi-triosephosphate isomerase inhibitors for Chagas disease treatment.Outcome of E1224-Benznidazole Combination Treatment for Infection with a Multidrug-Resistant Trypanosoma cruzi Strain in Mice.Glycosylated metal chelators as anti-parasitic agents with tunable selectivity.Validation of Apolipoprotein A-1 and Fibronectin Fragments as Markers of Parasitological Cure for Congenital Chagas Disease in Children Treated With Benznidazole

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Therapeutical approaches under investigation for treatment of Chagas disease.

http://www.wikidata.org/entity/Q38214136

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Expert Opinion on Investigational Drugs

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Therapeutical approaches under investigation for treatment of Chagas disease.

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Lívia de Figueiredo Diniz

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Maria Terezinha Bahia

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P2860

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Treatment with benznidazole during the chronic phase of experimental Chagas' disease decreases cardiac alterations

VNI cures acute and chronic experimental Chagas disease

Cysteine protease inhibitors cure an experimental Trypanosoma cruzi infection

A cysteine protease inhibitor cures Chagas' disease in an immunodeficient-mouse model of infection

Nonpeptidic Tetrafluorophenoxymethyl Ketone Cruzain Inhibitors as Promising New Leads for Chagas Disease Chemotherapy

Pharmacological Characterization, Structural Studies, and In Vivo Activities of Anti-Chagas Disease Lead Compounds Derived from Tipifarnib

Toxic side effects of drugs used to treat Chagas' disease (American trypanosomiasis)

Feasibility, drug safety, and effectiveness of etiological treatment programs for Chagas disease in Honduras, Guatemala, and Bolivia: 10-year experience of Médecins Sans Frontières

Combined treatment of heterocyclic analogues and benznidazole upon Trypanosoma cruzi in vivo

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1225-1237

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10.1517/13543784.2014.922952

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