Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases
about
Chronic over-nutrition and dysregulation of GSK3 in diseasesGlycogen synthase kinase-3β is a pivotal mediator of cancer invasion and resistance to therapyAntidepressant mechanism of ketamine: perspective from preclinical studiesMethane limit LPS-induced NF-κB/MAPKs signal in macrophages and suppress immune response in mice by enhancing PI3K/AKT/GSK-3β-mediated IL-10 expressionA Four-Point Screening Method for Assessing Molecular Mechanism of Action (MMOA) Identifies Tideglusib as a Time-Dependent Inhibitor of Trypanosoma brucei GSK3βA Hybrid Chalcone Combining the Trimethoxyphenyl and Isatinyl Groups Targets Multiple Oncogenic Proteins and Pathways in Hepatocellular Carcinoma CellsInsulin signaling regulates a functional interaction between adenomatous polyposis coli and cytoplasmic dynein.PI3K-resistant GSK3 controls adiponectin formation and protects from metabolic syndromeGSK3β Overexpression in Dentate Gyrus Neural Precursor Cells Expands the Progenitor Pool and Enhances Memory Skills.Resveratrol Attenuates Formaldehyde Induced Hyperphosphorylation of Tau Protein and Cytotoxicity in N2a CellsCooperative and independent functions of FGF and Wnt signaling during early inner ear development.SK3 Channel Overexpression in Mice Causes Hippocampal Shrinkage Associated with Cognitive Impairments.Aging and caloric restriction impact adipose tissue, adiponectin, and circulating lipidsTibolone modulates neuronal plasticity through regulating Tau, GSK3β/Akt/PI3K pathway and CDK5 p35/p25 complexes in the hippocampus of aged male mice.Glycogen synthase kinase 3β inhibitors prevent hepatitis C virus release/assembly through perturbation of lipid metabolismThe Glycogen Synthase Kinase 3α and β Isoforms Differentially Regulates Interleukin-12p40 Expression in Endothelial Cells Stimulated with Peptidoglycan from Staphylococcus aureusGlycogen synthase kinase-3 inhibition attenuates fibroblast activation and development of fibrosis following renal ischemia-reperfusion in mice.From Drug Screening to Target Deconvolution: a Target-Based Drug Discovery Pipeline Using Leishmania Casein Kinase 1 Isoform 2 To Identify Compounds with Antileishmanial Activity.GSK-3β-induced Tau pathology drives hippocampal neuronal cell death in Huntington's disease: involvement of astrocyte-neuron interactionsPhosphorylations of Serines 21/9 in Glycogen Synthase Kinase 3α/β Are Not Required for Cell Lineage Commitment or WNT Signaling in the Normal Mouse IntestineGSK-3 directly regulates phospho-4EBP1 in renal cell carcinoma cell-line: an intrinsic subcellular mechanism for resistance to mTORC1 inhibition.Stringent Control of NFE2L3 (Nuclear Factor, Erythroid 2-Like 3; NRF3) Protein Degradation by FBW7 (F-box/WD Repeat-containing Protein 7) and Glycogen Synthase Kinase 3 (GSK3).Regulation of Chlamydomonas flagella and ependymal cell motile cilia by ceramide-mediated translocation of GSK3The A-kinase Anchoring Protein GSKIP Regulates GSK3β Activity and Controls Palatal Shelf Fusion in Mice.Tumor Suppressor Lzap Suppresses Wnt/β-Catenin Signaling to Promote Zebrafish Embryonic Ventral Cell Fates via the Suppression of Inhibitory Phosphorylation of Glycogen Synthase Kinase 3.GR SUMOylation and formation of an SUMO-SMRT/NCoR1-HDAC3 repressing complex is mandatory for GC-induced IR nGRE-mediated transrepressionGlucocorticoid-induced tethered transrepression requires SUMOylation of GR and formation of a SUMO-SMRT/NCoR1-HDAC3 repressing complex.Glycogen synthase kinase-3: a potential preventive target for prostate cancer managementGSK3β isoform-selective regulation of depression, memory and hippocampal cell proliferation.Stress-induced neuroinflammation is mediated by GSK3-dependent TLR4 signaling that promotes susceptibility to depression-like behavior.Cardiac Stim1 Silencing Impairs Adaptive Hypertrophy and Promotes Heart Failure Through Inactivation of mTORC2/Akt Signaling.A Novel Glycogen Synthase Kinase-3 Inhibitor Optimized for Acute Myeloid Leukemia Differentiation Activity.Lithium to the Rescue.Molecular characterization of insulin resistance and glycolytic metabolism in the rat uterus.Histone deacetylase HDA6 enhances brassinosteroid signaling by inhibiting the BIN2 kinase.Impulsive alcohol-related risk-behavior and emotional dysregulation among individuals with a serotonin 2B receptor stop codonNovel Non-phosphorylated Serine 9/21 GSK3β/α Antibodies: Expanding the Tools for Studying GSK3 RegulationRegulation of persistent sodium currents by glycogen synthase kinase 3 encodes daily rhythms of neuronal excitability.A cAMP and CREB-mediated feed-forward mechanism regulates GSK3β in polycystic kidney disease.Tuberous sclerosis complex inactivation disrupts melanogenesis via mTORC1 activation.
P2860
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P2860
Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年論文
@yue
2014年論文
@zh-hant
2014年論文
@zh-hk
2014年論文
@zh-mo
2014年論文
@zh-tw
2014年论文
@wuu
2014年论文
@zh
2014年论文
@zh-cn
name
Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases
@en
type
label
Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases
@en
prefLabel
Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases
@en
P2093
P2860
P1476
Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases
@en
P2093
Eleonore Beurel
Richard S Jope
Steven F Grieco
P2860
P304
P356
10.1016/J.PHARMTHERA.2014.11.016
P577
2014-11-27T00:00:00Z