The Id3/E47 axis mediates cell-cycle control in human pancreatic ducts and adenocarcinoma.
about
ID proteins regulate diverse aspects of cancer progression and provide novel therapeutic opportunities.The basic helix-loop-helix transcription factor E47 reprograms human pancreatic cancer cells to a quiescent acinar state with reduced tumorigenic potential.Id3 upregulates BrdU incorporation associated with a DNA damage response, not replication, in human pancreatic β-cellsFootprintless disruption of prosurvival genes in aneuploid cancer cells using CRISPR/Cas9 technology.Effects of upregulation of Id3 in human lung adenocarcinoma cells on proliferation, apoptosis, mobility and tumorigenicity.PAK5-mediated E47 phosphorylation promotes epithelial-mesenchymal transition and metastasis of colon cancer.A network of broadly expressed HLH genes regulates tissue-specific cell fates.A screen for inducers of bHLH activity identifies pitavastatin as a regulator of p21, Rb phosphorylation and E2F target gene expression in pancreatic cancer.Genome-wide genetic and epigenetic analyses of pancreatic acinar cell carcinomas reveal aberrations in genome stability.Id2 Collaborates with Id3 To Suppress Invariant NKT and Innate-like Tumors.E47 Governs the MYC-CDKN1B/p27KIP1-RB Network to Growth Arrest PDA Cells Independent of CDKN2A/p16INK4A and Wild-Type p53.
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The Id3/E47 axis mediates cell-cycle control in human pancreatic ducts and adenocarcinoma.
description
2011 nî lūn-bûn
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2011年の論文
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年学术文章
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2011年學術文章
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2011年學術文章
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2011年學術文章
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name
The Id3/E47 axis mediates cell ...... atic ducts and adenocarcinoma.
@en
type
label
The Id3/E47 axis mediates cell ...... atic ducts and adenocarcinoma.
@en
prefLabel
The Id3/E47 axis mediates cell ...... atic ducts and adenocarcinoma.
@en
P2093
P2860
P1476
The Id3/E47 axis mediates cell ...... atic ducts and adenocarcinoma.
@en
P2093
Alice Kiselyuk
Andrew Lowy
David J Shields
Ergeng Hao
Fred Levine
James Shapiro
Pamela Itkin-Ansari
Seung-Hee Lee
P2860
P304
P356
10.1158/1541-7786.MCR-10-0535
P577
2011-04-15T00:00:00Z