The orphan nuclear receptor DAX1 is up-regulated by the EWS/FLI1 oncoprotein and is highly expressed in Ewing tumors.
about
Potential approaches to the treatment of Ewing's sarcomaThe oncogenic EWS-FLI1 protein binds in vivo GGAA microsatellite sequences with potential transcriptional activation functionTumorigenic role of orphan nuclear receptor NR0B1 in lung adenocarcinomaThe TET family of proteins: functions and roles in disease.Lysyl oxidase is downregulated by the EWS/FLI1 oncoprotein and its propeptide domain displays tumor supressor activities in Ewing sarcoma cells.Identification of an inhibitor of the EWS-FLI1 oncogenic transcription factor by high-throughput screening.Oncogenic fusion protein EWS/FLI1 down-regulates gene expression by both transcriptional and posttranscriptional mechanismsDAX-1 Expression in Pediatric Rhabdomyosarcomas: Another Immunohistochemical Marker Useful in the Diagnosis of Translocation Positive Alveolar Rhabdomyosarcoma.Oncogenic partnerships: EWS-FLI1 protein interactions initiate key pathways of Ewing's sarcoma.A molecular function map of Ewing's sarcoma.Stable interference of EWS-FLI1 in an Ewing sarcoma cell line impairs IGF-1/IGF-1R signalling and reveals TOPK as a new target.Genetic p53 deficiency partially rescues the adrenocortical dysplasia phenotype at the expense of increased tumorigenesis.Targeting the epigenetic readers in Ewing sarcoma inhibits the oncogenic transcription factor EWS/Fli1.Molecular abnormalities in Ewing's sarcoma.Minireview: role of orphan nuclear receptors in cancer and potential as drug targetsEpigenetic modifications promote the expression of the orphan nuclear receptor NR0B1 in human lung adenocarcinoma cells.Targeting DAX-1 in embryonic stem cells and cancer.The orphan nuclear receptors in cancer and diabetes.EWS/FLI1 Target Genes and Therapeutic Opportunities in Ewing Sarcoma.Generation of conditional oncogenic chromosomal translocations using CRISPR-Cas9 genomic editing and homology-directed repair.Potential downstream target genes of aberrant ETS transcription factors are differentially affected in Ewing's sarcoma and prostate carcinoma.EWS-FLI1-mediated suppression of the RAS-antagonist Sprouty 1 (SPRY1) confers aggressiveness to Ewing sarcoma.The EWS/FLI1 oncogenic protein inhibits expression of the Wnt inhibitor DICKKOPF-1 gene and antagonizes beta-catenin/TCF-mediated transcription.Retinoic acid-induced nNOS expression depends on a novel PI3K/Akt/DAX1 pathway in human TGW-nu-I neuroblastoma cells.Dr. Jekyll and Mr. Hyde: The Two Faces of the FUS/EWS/TAF15 Protein Family.Identification of Mithramycin Analogues with Improved Targeting of the EWS-FLI1 Transcription FactorMicrosatellites with macro-influence in ewing sarcomaThe expression of nr0b1, the earliest gene in zebrafish tooth development, is a marker for human tooth and ameloblastoma formation.Lurbinectedin Inactivates the Ewing Sarcoma Oncoprotein EWS-FLI1 by Redistributing It within the Nucleus.A phase I/II trial and pharmacokinetic study of mithramycin in children and adults with refractory Ewing sarcoma and EWS-FLI1 fusion transcript.DAX1 promotes cervical cancer cell growth and tumorigenicity through activation of Wnt/β-catenin pathway via GSK3β.Array CGH and gene-expression profiling reveals distinct genomic instability patterns associated with DNA repair and cell-cycle checkpoint pathways in Ewing's sarcoma.Role of Orphan Nuclear Receptor DAX-1/NR0B1 in Development, Physiology, and Disease
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P2860
The orphan nuclear receptor DAX1 is up-regulated by the EWS/FLI1 oncoprotein and is highly expressed in Ewing tumors.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
@zh
2006年學術文章
@zh-hant
name
The orphan nuclear receptor DA ...... hly expressed in Ewing tumors.
@en
type
label
The orphan nuclear receptor DA ...... hly expressed in Ewing tumors.
@en
prefLabel
The orphan nuclear receptor DA ...... hly expressed in Ewing tumors.
@en
P2093
P2860
P50
P356
P1476
The orphan nuclear receptor DA ...... hly expressed in Ewing tumors.
@en
P2093
Angel Pestaña
Eva García
Fernando López-Barea
Jaime Carrillo
Marta Mendiola
Purificación García-Miguel
Teresa Hernández
P2860
P304
P356
10.1002/IJC.21578
P577
2006-03-01T00:00:00Z