about
Behavioral alterations associated with apoptosis and down-regulation of presenilin 1 in the brains of p53-deficient miceTMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activityDays to criterion as an indicator of toxicity associated with human Alzheimer amyloid-beta oligomersMT5-MMP is a new pro-amyloidogenic proteinase that promotes amyloid pathology and cognitive decline in a transgenic mouse model of Alzheimer's disease.Neprilysin activity and expression are controlled by nicastrinPresenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiencyPresenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLPPresenilin 1 and Presenilin 2 Target γ-Secretase Complexes to Distinct Cellular Compartments.Constitutive alpha-secretase cleavage of the beta-amyloid precursor protein in the furin-deficient LoVo cell line: involvement of the pro-hormone convertase 7 and the disintegrin metalloprotease ADAM10.Presenilins: structural aspects and posttranslational events.Amyloid β production is regulated by β2-adrenergic signaling-mediated post-translational modifications of the ryanodine receptor.S 17092-1, a highly potent, specific and cell permeant inhibitor of human proline endopeptidase.Confocal microscopy reveals thimet oligopeptidase (EC 3.4.24.15) and neurolysin (EC 3.4.24.16) in the classical secretory pathway.Amyloid precursor protein, presenilins, and alpha-synuclein: molecular pathogenesis and pharmacological applications in Alzheimer's disease.Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease.Endopeptidase 24-16 in murines: tissue distribution, cerebral regionalization, and ontogeny.N-truncated Aβ peptides in complex fluids unraveled by new specific immunoassays.Synthesis and analgesic effects of N-[3-[(hydroxyamino) carbonyl]-1-oxo-2(R)-benzylpropyl]-L-isoleucyl-L-leucine, a new potent inhibitor of multiple neurotensin/neuromedin N degrading enzymes.Eph receptors: new players in Alzheimer's disease pathogenesis.The β-secretase-derived C-terminal fragment of βAPP, C99, but not Aβ, is a key contributor to early intraneuronal lesions in triple-transgenic mouse hippocampus.Cerebrospinal Aβ11-x and 17-x levels as indicators of mild cognitive impairment and patients' stratification in Alzheimer's disease.Alzheimer's and prion diseases: distinct pathologies, common proteolytic denominators.Examination of the role of endopeptidase 3.4.24.15 in A beta secretion by human transfected cells.Effect of protein kinase A inhibitors on the production of Abeta40 and Abeta42 by human cells expressing normal and Alzheimer's disease-linked mutated betaAPP and presenilin 1.Design and characterization of a new cell-permeant inhibitor of the beta-secretase BACE1.p53-dependent control of transactivation of the Pen2 promoter by presenilinsThe extracellular regulated kinase-1 (ERK1) controls regulated alpha-secretase-mediated processing, promoter transactivation, and mRNA levels of the cellular prion protein.Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the london mutant of human APP in neurons.Intraneuronal Abeta42 accumulation in human brain.The Polyherbal Wattana Formula Displays Anti-Amyloidogenic Properties by Increasing α-Secretase Activities.BACE1 is at the crossroad of a toxic vicious cycle involving cellular stress and β-amyloid production in Alzheimer's diseaseUnusual phenotypic alteration of beta amyloid precursor protein (betaAPP) maturation by a new Val-715 --> Met betaAPP-770 mutation responsible for probable early-onset Alzheimer's disease.Direct α-synuclein promoter transactivation by the tumor suppressor p53.The gamma/epsilon-secretase-derived APP intracellular domain fragments regulate p53.Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology.ADAM30 Downregulates APP-Linked Defects Through Cathepsin D Activation in Alzheimer's Disease.APH1 polar transmembrane residues regulate the assembly and activity of presenilin complexesLoss of function of DJ-1 triggered by Parkinson's disease-associated mutation is due to proteolytic resistance to caspase-6.Localization and Processing of the Amyloid-β Protein Precursor in Mitochondria-Associated Membranes.The physiology of the β-amyloid precursor protein intracellular domain AICD.
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Frédéric Checler
@ast
Frédéric Checler
@en
Frédéric Checler
@es
Frédéric Checler
@nl
Frédéric Checler
@sl
type
label
Frédéric Checler
@ast
Frédéric Checler
@en
Frédéric Checler
@es
Frédéric Checler
@nl
Frédéric Checler
@sl
prefLabel
Frédéric Checler
@ast
Frédéric Checler
@en
Frédéric Checler
@es
Frédéric Checler
@nl
Frédéric Checler
@sl
P1053
C-1241-2009
P106
P21
P31
P3829
P496
0000-0003-2098-1750