about
Fourteen residues of the U1 snRNP-specific U1A protein are required for homodimerization, cooperative RNA binding, and inhibition of polyadenylation.Structure and DNA binding of the human Rtf1 Plus3 domainE2-c-Cbl recognition is necessary but not sufficient for ubiquitination activitySymmetry and asymmetry of the RING-RING dimer of Rad18Solution structure of the human ubiquitin-specific protease 15 DUSP domainReal-time analysis of the detailed sequence of cellular events in mAb-mediated complement-dependent cytotoxicity of B-cell lines and of chronic lymphocytic leukemia B-cells.NMR in the SPINE Structural Proteomics project.Human IgG is produced in a pro-form that requires clipping of C-terminal lysines for maximal complement activationComplement is activated by IgG hexamers assembled at the cell surface.Recruitment of the priming protein pTP and DNA binding occur by overlapping Oct-1 POU homeodomain surfacesMechanism of DNA replication in eukaryotic cells: cellular host factors stimulating adenovirus DNA replication.Adalimumab elicits a restricted anti-idiotypic antibody response in autoimmune patients resulting in functional neutralisation.Adenovirus DNA replication: protein priming, jumping back and the role of the DNA binding protein DBP.A Novel Platform for the Potentiation of Therapeutic Antibodies Based on Antigen-Dependent Formation of IgG Hexamers at the Cell Surface.First steps towards effective methods in exploiting high-throughput technologies for the determination of human protein structures of high biomedical value.HER2 monoclonal antibodies that do not interfere with receptor heterodimerization-mediated signaling induce effective internalization and represent valuable components for rational antibody-drug conjugate designFunctional analysis of the anti-adalimumab response using patient-derived monoclonal antibodies.DNA binding properties of the adenovirus DNA replication priming protein pTP.Molecular Basis of Assembly and Activation of Complement Component C1 in Complex with Immunoglobulin G1 and Antigen.A simple, robust and highly efficient transient expression system for producing antibodies.A direct interaction between proliferating cell nuclear antigen (PCNA) and Cdk2 targets PCNA-interacting proteins for phosphorylation.Tandem Native Mass-Spectrometry on Antibody-Drug Conjugates and Submillion Da Antibody-Antigen Protein Assemblies on an Orbitrap EMR Equipped with a High-Mass Quadrupole Mass Selector.Enhancing Accuracy in Molecular Weight Determination of Highly Heterogeneously Glycosylated Proteins by Native Tandem Mass SpectrometryNMR characterization of foldedness for the production of E3 RING domains.Relaxed template specificity in fowl adenovirus 1 DNA replication initiation.Kinetic mechanism of controlled Fab-arm exchange for the formation of bispecific immunoglobulin G1 antibodies.Controlled Fab-arm exchange for the generation of stable bispecific IgG1.Cysteine-SILAC Mass Spectrometry Enabling the Identification and Quantitation of Scrambled Interchain Disulfide Bonds: Preservation of Native Heavy-Light Chain Pairing in Bispecific IgGs Generated by Controlled Fab-arm Exchange.Structures of C1-IgG1 provide insights into how danger pattern recognition activates complement.Structural characterization of Spo0E-like protein-aspartic acid phosphatases that regulate sporulation in bacilli.The Structure of Bypass of Forespore C, an Intercompartmental Signaling Factor during Sporulation inBacillusCD20 and CD37 antibodies synergize to activate complement by Fc-mediated clustering.Enzyme free cloning for high throughput gene cloning and expressionUnraveling the Macromolecular Pathways of IgG Oligomerization and Complement Activation on Antigenic Surfaces
P50
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P50
description
hulumtues
@sq
researcher
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ricercatore
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wetenschapper
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հետազոտող
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name
Rob N de Jong
@ast
Rob N de Jong
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Rob N de Jong
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Rob N de Jong
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Rob de Jong
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type
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Rob N de Jong
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Rob N de Jong
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Rob N de Jong
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Rob N de Jong
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Rob de Jong
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Rob N. de Jong
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prefLabel
Rob N de Jong
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Rob N de Jong
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Rob N de Jong
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Rob N de Jong
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Rob de Jong
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P108
P1006
P214
P1006
P106
P1153
34467511700
P21
P213
0000 0003 8899 6377
P214
P31
P496
0000-0002-9300-6633
P734
P735
P7859
viaf-282275023