about
Crystal Structure of a Hidden Protein, YcaC, a Putative Cysteine Hydrolase from Pseudomonas aeruginosa, with and without an Acrylamide AdductAn evolutionarily conserved coiled-coil protein implicated in polycystic kidney disease is involved in basal body duplication and flagellar biogenesis in Trypanosoma bruceiAqueous synthesis of N,S-dialkylthiophosphoramidates: design, optimisation and application to library construction and antileishmanial testing.A plastid of probable green algal origin in Apicomplexan parasites.The endocytic apparatus of the kinetoplastida. Part II: machinery and components of the system.Rafts and sphingolipid biosynthesis in the kinetoplastid parasitic protozoa.Sphingolipid synthesis and scavenging in the intracellular apicomplexan parasite, Toxoplasma gondiiAntimicrobial peptides for leishmaniasis.The utility of yeast as a tool for cell-based, target-directed high-throughput screening.Yeast as a potential vehicle for neglected tropical disease drug discovery.Endocytosis and Sphingolipid Scavenging in Leishmania mexicana Amastigotes.Everybody needs sphingolipids, right! Mining for new drug targets in protozoan sphingolipid biosynthesis.The antifungal Aureobasidin A and an analogue are active against the protozoan parasite Toxoplasma gondii but do not inhibit sphingolipid biosynthesis.An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity.Studies on the antileishmanial properties of the antimicrobial peptides temporin A, B and 1Sa.Repurposing as a strategy for the discovery of new anti-leishmanials: the-state-of-the-art.The role of phosphoglycans in the susceptibility of Leishmania mexicana to the temporin family of anti-microbial peptides.The protozoan inositol phosphorylceramide synthase: a novel drug target that defines a new class of sphingolipid synthase.Direct transport across the plasma membrane of mammalian cells of Leishmania HASPB as revealed by a CHO export mutant.Expression of the AM gene locus in infective stages of Leishmania.Functional and phylogenetic evidence of a bacterial origin for the first enzyme in sphingolipid biosynthesis in a phylum of eukaryotic protozoan parasites.Investigating the anti-leishmanial effects of linear peptoids.Lipid metabolism as a therapeutic target.Functional analyses of differentially expressed isoforms of the Arabidopsis inositol phosphorylceramide synthase.Leishmania RAB7: characterisation of terminal endocytic stages in an intracellular parasite.Sphingolipid-free Leishmania are defective in membrane trafficking, differentiation and infectivity.Ether phospholipids and glycosylinositolphospholipids are not required for amastigote virulence or for inhibition of macrophage activation by Leishmania major.Exploring Leishmania major inositol phosphorylceramide synthase (LmjIPCS): insights into the ceramide binding domain.The Trypanosoma brucei sphingolipid synthase, an essential enzyme and drug target.Microbial protein targets: towards understanding and intervention.The in vivo conformation of the plastid DNA of Toxoplasma gondii: implications for replication.Evidence for a Single Origin of the 35 kb Plastid DNA in Apicomplexans.Thiostrepton binds to malarial plastid rRNA.A complex interplay between sphingolipid and sterol metabolism revealed by perturbations to the Leishmania metabolome caused by miltefosine.Leishmania major: clathrin and adaptin complexes of an intra-cellular parasite.Identifying inhibitors of the Leishmania inositol phosphorylceramide synthase with antiprotozoal activity using a yeast-based assay and ultra-high throughput screening platform.The antifungal Aureobasidin A and an analogue are active against the protozoan parasite Toxoplasma gondii but do not inhibit sphingolipid biosynthesis - Corrigendum.Acylation-dependent Protein Export in LeishmaniaYeast: bridging the gap between phenotypic and biochemical assays for high-throughput screeningTamoxifen inhibits the biosynthesis of inositolphosphorylceramide in Leishmania
P50
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P50
description
hulumtues
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researcher
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wetenschapper
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հետազոտող
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name
Paul W Denny
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Paul W Denny
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Paul W Denny
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Paul W Denny
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Paul W Denny
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type
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Paul W Denny
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Paul W Denny
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Paul W Denny
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Paul W Denny
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Paul W Denny
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Paul W Denny
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Paul W Denny
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Paul W Denny
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Paul W Denny
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Paul W Denny
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P106
P21
P31
P496
0000-0002-5051-1613