Direct Modulation of Small GTPase Activity and Function.
about
Constraining an Irregular Peptide Secondary Structure through Ring-Closing Alkyne MetathesisAntibody targeting intracellular oncogenic Ras mutants exerts anti-tumour effects after systemic administration.Inhibitors of Ras-SOS Interactions.The RAS-Effector Interface: Isoform-Specific Differences in the Effector Binding RegionsInhibition of prenylated KRAS in a lipid environmentOpposite feedback from mTORC1 to H-ras and K-ras4B downstream of SREBP1.Molecular perturbation strategies to examine spatiotemporal features of Rho GEF and Rho GTPase activity in living cells.Exploring the interactions of the RAS family in the human protein network and their potential implications in RAS-directed therapies.Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view.Latest Advances Towards Ras Inhibition: A Medicinal Chemistry Perspective.High pressure 31P NMR spectroscopy on guanine nucleotides.Targeted Protein Degradation: from Chemical Biology to Drug Discovery.Orthogonal ring-closing alkyne and olefin metathesis for the synthesis of small GTPase-targeting bicyclic peptides.Identification of a New Potent Inhibitor Targeting KRAS in Non-small Cell Lung Cancer Cells.Design of small molecules that compete with nucleotide binding to an engineered oncogenic KRAS allele.Rufy3 is an adapter protein for small GTPases that activates a Rac guanine nucleotide exchange factor to control neuronal polarity.GTPase-activating protein Elmod2 is essential for meiotic progression in mouse oocytes.Development of a Nucleotide Exchange Inhibitor That Impairs Ras Oncogenic Signaling.Identification of a Fragmented Small GTPase Capable of Conditional Effector Binding.A PDE6δ-KRas Inhibitor Chemotype with up to Seven H-Bonds and Picomolar Affinity that Prevents Efficient Inhibitor Release by Arl2.Allosteric Activation of GDP-Bound Ras Isoforms by Bisphenol Derivative Plasticisers.
P2860
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P2860
Direct Modulation of Small GTPase Activity and Function.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Direct Modulation of Small GTPase Activity and Function.
@en
type
label
Direct Modulation of Small GTPase Activity and Function.
@en
prefLabel
Direct Modulation of Small GTPase Activity and Function.
@en
P2860
P50
P356
P1476
Direct Modulation of Small GTPase Activity and Function.
@en
P2860
P304
13516-13537
P356
10.1002/ANIE.201504357
P407
P577
2015-10-16T00:00:00Z