Mechanistic models enable the rational use of in vitro drug-target binding kinetics for better drug effects in patients.
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Public-Private Partnerships in Lead Discovery: Overview and Case Studies.Drug-Target Kinetics in Drug Discovery.The Added Value of Assessing Ligand-Receptor Binding Kinetics in Drug Discovery.Distinct in vivo target occupancy by bivalent- and induced-fit-like binding drugs.Novel CNS drug discovery and development approach: model-based integration to predict neuro-pharmacokinetics and pharmacodynamics.Unified Software Solution for Efficient SPR Data Analysis in Drug ResearchModelling the delay between pharmacokinetics and EEG effects of morphine in rats: binding kinetic versus effect compartment modelsIn vitro and in silico analysis of the effects of D receptor antagonist target binding kinetics on the cellular response to fluctuating dopamine concentrations
P2860
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P2860
Mechanistic models enable the rational use of in vitro drug-target binding kinetics for better drug effects in patients.
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2015 nî lūn-bûn
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name
Mechanistic models enable the ...... tter drug effects in patients.
@en
type
label
Mechanistic models enable the ...... tter drug effects in patients.
@en
prefLabel
Mechanistic models enable the ...... tter drug effects in patients.
@en
P2093
P2860
P50
P1476
Mechanistic models enable the ...... tter drug effects in patients.
@en
P2093
Indira Nederpelt
Laura H Heitman
Meindert Danhof
Piet H van der Graaf
Ron A H J Gilissen
P2860
P356
10.1517/17460441.2016.1100163
P407
P577
2015-10-20T00:00:00Z