Juglone, an inhibitor of the peptidyl-prolyl isomerase Pin1, also directly blocks transcription.
about
Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c-Jun towards cyclin D1.Small family with key contacts: par14 and par17 parvulin proteins, relatives of pin1, now emerge in biomedical researchMultisite phosphorylation of Pin1-associated mitotic phosphoproteins revealed by monoclonal antibodies MPM-2 and CC-3The prolyl isomerase Pin1 in breast development and cancerUnderstanding the role of PIN1 in hepatocellular carcinomaBiosynthesis and molecular actions of specialized 1,4-naphthoquinone natural products produced by horticultural plantsPeptidyl-prolyl isomerase 1 regulates protein phosphatase 2A-mediated topographic phosphorylation of neurofilament proteinsRegulation of cardiac hypertrophic signaling by prolyl isomerase Pin1The peptidylprolyl cis/trans-isomerase Pin1 modulates stress-induced dephosphorylation of Tau in neurons. Implication in a pathological mechanism related to Alzheimer diseaseAn essential role for Pin1 in Xenopus laevis embryonic development revealed by specific inhibitors.Pin1 modulates the type 1 immune responseThe Ess1 prolyl isomerase: traffic cop of the RNA polymerase II transcription cycle.Peptidyl-prolyl isomerase Pin1 is a cellular factor required for hepatitis C virus propagation.The prolyl isomerase Pin1 induces LC-3 expression and mediates tamoxifen resistance in breast cancer.Prolyl isomerase Pin1 regulates mouse embryonic fibroblast differentiation into adipose cells.Anticancer activity and mechanism of juglone on human cervical carcinoma HeLa cells.Peptidyl-prolyl isomerases: a new twist to transcription.Prolyl isomerases in gene transcriptionPIN1 inhibition suppresses osteoclast differentiation and inflammatory responses.Activity guided isolation and modification of juglone from Juglans regia as potent cytotoxic agent against lung cancer cell linesInhibition of Pin1 reduces glutamate-induced perikaryal accumulation of phosphorylated neurofilament-H in neurons.Overexpression of PIN1 Enhances Cancer Growth and Aggressiveness with Cyclin D1 Induction in EBV-Associated Nasopharyngeal Carcinoma.Pin1 regulates TGF-beta1 production by activated human and murine eosinophils and contributes to allergic lung fibrosis.Cell cycle-dependent changes in H3K56ac in human cellsRegulation of PRDX1 peroxidase activity by Pin1.Pin1-dependent prolyl isomerization modulates the stress-induced phosphorylation of high molecular weight neurofilament protein.Prolyl isomerase Pin1 is highly expressed in Her2-positive breast cancer and regulates erbB2 protein stability.Nature as a source of metabolites with cholinesterase-inhibitory activity: an approach to Alzheimer's disease treatment.Peptidyl-prolyl isomerases: functionality and potential therapeutic targets in cardiovascular disease.Pin1 dysregulation helps to explain the inverse association between cancer and Alzheimer's disease.The isomerase PIN1 controls numerous cancer-driving pathways and is a unique drug target.Pin1 promotes GR transactivation by enhancing recruitment to target genes.Pin1, a new player in the fate of HIF-1α degradation: an hypothetical mechanism inside vascular damage as Alzheimer's disease risk factor.Further characterization of Bacillus subtilis antibiotic biosensors and their use for antibacterial mode-of-action studiesLimited effectiveness of antioxidants in the protection of yeast defective in antioxidant proteins.Juglone inactivates cysteine-rich proteins required for progression through mitosis.Salt Stress and CTD PHOSPHATASE-LIKE4 Mediate the Switch between Production of Small Nuclear RNAs and mRNAs.Pin1 Promotes Regulated Necrosis Induced by Glutamate in Rat Retinal Neurons via CAST/Calpain2 Pathway.Manipulating PML SUMOylation via Silencing UBC9 and RNF4 Regulates Cardiac Fibrosis.
P2860
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P2860
Juglone, an inhibitor of the peptidyl-prolyl isomerase Pin1, also directly blocks transcription.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
Juglone, an inhibitor of the p ...... directly blocks transcription.
@en
type
label
Juglone, an inhibitor of the p ...... directly blocks transcription.
@en
prefLabel
Juglone, an inhibitor of the p ...... directly blocks transcription.
@en
P2093
P2860
P356
P1476
Juglone, an inhibitor of the p ...... directly blocks transcription.
@en
P2093
A L Greenleaf
P2860
P304
P356
10.1093/NAR/29.3.767
P407
P577
2001-02-01T00:00:00Z