Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2.
about
Selective silencing of euchromatic L1s revealed by genome-wide screens for L1 regulators.MORC2B is essential for meiotic progression and fertility.Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms.The HUSH complex cooperates with TRIM28 to repress young retrotransposons and new genes.
P2860
Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2.
description
2017 nî lūn-bûn
@nan
2017年の論文
@ja
2017年論文
@yue
2017年論文
@zh-hant
2017年論文
@zh-hk
2017年論文
@zh-mo
2017年論文
@zh-tw
2017年论文
@wuu
2017年论文
@zh
2017年论文
@zh-cn
name
Hyperactivation of HUSH comple ...... oth disease mutation in MORC2.
@en
type
label
Hyperactivation of HUSH comple ...... oth disease mutation in MORC2.
@en
prefLabel
Hyperactivation of HUSH comple ...... oth disease mutation in MORC2.
@en
P2093
P2860
P50
P921
P356
P1433
P1476
Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2
@en
P2093
Gordon Dougan
Rhys C Roberts
Richard T Timms
Robert E Kingston
P2860
P2888
P304
P356
10.1038/NG.3878
P407
P577
2017-06-05T00:00:00Z