Next-generation sequencing identifies a novel ELAVL1-TYK2 fusion gene in MOLM-16, an AML cell line highly sensitive to the PIM kinase inhibitor AZD1208.

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FLT3-ITD induces expression of Pim kinases through STAT5 to confer resistance to the PI3K/Akt pathway inhibitors on leukemic cells by enhancing the mTORC1/Mcl-1 pathway.

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Next-generation sequencing identifies a novel ELAVL1-TYK2 fusion gene in MOLM-16, an AML cell line highly sensitive to the PIM kinase inhibitor AZD1208.

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http://www.wikidata.org/entity/Q38770271

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2016 nî lūn-bûn

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2016年の論文

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2016年論文

@yue

2016年論文

@zh-hant

2016年論文

@zh-hk

2016年論文

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2016年論文

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2016年论文

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2016年论文

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name

Next-generation sequencing ide ...... PIM kinase inhibitor AZD1208.

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type

Item

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Next-generation sequencing ide ...... PIM kinase inhibitor AZD1208.

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Next-generation sequencing ide ...... PIM kinase inhibitor AZD1208.

@en

P1476

Next-generation sequencing ide ...... PIM kinase inhibitor AZD1208.

@en

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Adriana E Tron

http://www.w3.org/2001/XMLSchema#string

Asim Khwaja

http://www.w3.org/2001/XMLSchema#string

Chloe Stengel

http://www.w3.org/2001/XMLSchema#string

David C Linch

http://www.w3.org/2001/XMLSchema#string

Dennis Huszar

http://www.w3.org/2001/XMLSchema#string

Erika K Keeton

http://www.w3.org/2001/XMLSchema#string

Huawei Chen

http://www.w3.org/2001/XMLSchema#string

Keith S Dillman

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Matias Casas-Selves

http://www.w3.org/2001/XMLSchema#string

Michael Zinda

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P2860

Structure of the pseudokinase-kinase domains from protein kinase TYK2 reveals a mechanism for Janus kinase (JAK) autoinhibition

Complementary functions of the antiapoptotic protein A1 and serine/threonine kinase pim-1 in the BCR/ABL-mediated leukemogenesis

Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia.

Transcriptional responses to polypeptide ligands: the JAK-STAT pathway

Clinical importance of cytogenetics in acute myeloid leukaemia.

Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.

Emerging therapeutic paradigms to target the dysregulated Janus kinase/signal transducer and activator of transcription pathway in hematological malignancies

AZD1208, a potent and selective pan-Pim kinase inhibitor, demonstrates efficacy in preclinical models of acute myeloid leukemia.

For better or for worse: the role of Pim oncogenes in tumorigenesis.

Suppression of myeloid transcription factors and induction of STAT response genes by AML-specific Flt3 mutations.

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2927-2929

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scholarly article

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10.3109/10428194.2016.1171861

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P478

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2016-05-17T00:00:00Z

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27189703

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Next-generation sequencing identifies a novel ELAVL1-TYK2 fusion gene in MOLM-16, an AML cell line highly sensitive to the PIM kinase inhibitor AZD1208.

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P2860

P2860

Next-generation sequencing identifies a novel ELAVL1-TYK2 fusion gene in MOLM-16, an AML cell line highly sensitive to the PIM kinase inhibitor AZD1208.

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P1476

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P433

P478

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P698

P356

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P1476

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P2860

P304

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P433

P478

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