The small GTPase Rab11 co-localizes with α-synuclein in intracellular inclusions and modulates its aggregation, secretion and toxicity.
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Extracellular Vesicles and a Novel Form of Communication in the BrainThe complex relationships between microglia, alpha-synuclein, and LRRK2 in Parkinson's diseaseA Novel Microfluidic Cell Co-culture Platform for the Study of the Molecular Mechanisms of Parkinson's Disease and Other SynucleinopathiesSynuclein impairs trafficking and signaling of BDNF in a mouse model of Parkinson's disease.Mitochondrial Dysfunction and α-Synuclein Synaptic Pathology in Parkinson's Disease: Who's on First?Mevalonate Pathway Regulates Cell Size Homeostasis and Proteostasis through AutophagyshRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity.ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons.Axonal transport and secretion of fibrillar forms of α-synuclein, Aβ42 peptide and HTTExon 1Rab11 modulates α-synuclein-mediated defects in synaptic transmission and behaviourEnvironmental and genetic factors support the dissociation between α-synuclein aggregation and toxicity.Increased Rab35 expression is a potential biomarker and implicated in the pathogenesis of Parkinson's disease.Rab GTPases: The Key Players in the Molecular Pathway of Parkinson's Disease.Neuronal aggregates: formation, clearance, and spreading.Structure, function and toxicity of alpha-synuclein: the Bermuda triangle in synucleinopathies.Review: Parkinson's disease: from synaptic loss to connectome dysfunction.Physiological and pathological roles of exosomes in the nervous system.Alpha-synuclein modulates retinal iron homeostasis by facilitating the uptake of transferrin-bound iron: Implications for visual manifestations of Parkinson's disease.Cellular models for Parkinson's disease.Cellular Uptake of α-Synuclein Oligomer-Selective Antibodies is Enhanced by the Extracellular Presence of α-Synuclein and Mediated via Fcγ Receptors.Extracellular vesicles and intercellular communication within the nervous system.Rabs, Membrane Dynamics, and Parkinson's Disease.Selective LRRK2 kinase inhibition reduces phosphorylation of endogenous Rab10 and Rab12 in human peripheral mononuclear blood cells.Traffic jams and the complex role of α-Synuclein aggregation in Parkinson disease.GABA transmission via ATP-dependent K+ channels regulates α-synuclein secretion in mouse striatum.The emerging role of Rab GTPases in the pathogenesis of Parkinson's disease.Rab7 induces clearance of α-synuclein aggregates.Dysregulated phosphorylation of Rab GTPases by LRRK2 induces neurodegeneration.Mechanisms of α-Synuclein Induced Synaptopathy in Parkinson's Disease.Rab GTPases and Membrane Trafficking in Neurodegeneration.Membrane binding, internalization, and sorting of alpha-synuclein in the cell
P2860
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P2860
The small GTPase Rab11 co-localizes with α-synuclein in intracellular inclusions and modulates its aggregation, secretion and toxicity.
description
2014 nî lūn-bûn
@nan
2014年の論文
@ja
2014年学术文章
@wuu
2014年学术文章
@zh-cn
2014年学术文章
@zh-hans
2014年学术文章
@zh-my
2014年学术文章
@zh-sg
2014年學術文章
@yue
2014年學術文章
@zh
2014年學術文章
@zh-hant
name
The small GTPase Rab11 co-loca ...... ation, secretion and toxicity.
@en
type
label
The small GTPase Rab11 co-loca ...... ation, secretion and toxicity.
@en
prefLabel
The small GTPase Rab11 co-loca ...... ation, secretion and toxicity.
@en
P2093
P2860
P50
P356
P1476
The small GTPase Rab11 co-loca ...... ation, secretion and toxicity.
@en
P2093
Anna Villar-Piqué
Evangelia Emmanouilidou
Flaviano Giorgini
Jochen Klucken
Kostas Vekrellis
Oldriska Chutna
Tiago F Outeiro
Tiago Mendes
Zrinka Marijanovic
P2860
P304
P356
10.1093/HMG/DDU391
P577
2014-08-04T00:00:00Z