about
Tumour Cell HeterogeneityField cancerization in Barrett's esophagusGremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential.Quantification of crypt and stem cell evolution in the normal and neoplastic human colonSolutions to Peto's paradox revealed by mathematical modelling and cross-species cancer gene analysisA basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tractsThe clonal origins of dysplasia from intestinal metaplasia in the human stomach.Field cancerization in the intestinal epithelium of patients with Crohn's ileocolitis.Barrett's metaplasia glands are clonal, contain multiple stem cells and share a common squamous progenitor.Crypt dysplasia in Barrett's oesophagus shows clonal identity between crypt and surface cells.Clonal selection and persistence in dysplastic Barrett's esophagus and intramucosal cancers after failed radiofrequency ablation.Krt19(+)/Lgr5(-) Cells Are Radioresistant Cancer-Initiating Stem Cells in the Colon and Intestine.Forty-Year Analysis of Colonoscopic Surveillance Program for Neoplasia in Ulcerative Colitis: An Updated Overview.A Big Bang model of human colorectal tumor growth.Quantification of within-sample genetic heterogeneity from SNP-array data.Low-grade dysplasia in ulcerative colitis: risk factors for developing high-grade dysplasia or colorectal cancer.Differential clonal evolution in oesophageal cancers in response to neo-adjuvant chemotherapyEvolution of oesophageal adenocarcinoma from metaplastic columnar epithelium without goblet cells in Barrett's oesophagusLineage tracing reveals multipotent stem cells maintain human adenomas and the pattern of clonal expansion in tumor evolution.Stochastic homeostasis in human airway epithelium is achieved by neutral competition of basal cell progenitorsLRIG1 regulates cadherin-dependent contact inhibition directing epithelial homeostasis and pre-invasive squamous cell carcinoma development.Investigating the fixation and spread of mutations in the gastrointestinal epithelium.Stem cells and solid cancers.Genetic diversity during the development of Barrett's oesophagus-associated adenocarcinoma: how, when and why?Stem cells and their implications for colorectal cancer.Stem cells and inflammation in the intestine.Field cancerization in the GI tract.Pre-tumour clones, periodic selection and clonal interference in the origin and progression of gastrointestinal cancer: potential for biomarker development.Between-region genetic divergence reflects the mode and tempo of tumor evolution.New paradigms in clonal evolution: punctuated equilibrium in cancer.Measuring cancer evolution from the genome.Catch my drift? Making sense of genomic intra-tumour heterogeneity.Analysis of copy number changes suggests chromosomal instability in a minority of large colorectal adenomas.Cell migration leads to spatially distinct but clonally related airway cancer precursors.Identification of neutral tumor evolution across cancer types.Pan-cancer analysis of the extent and consequences of intratumor heterogeneity.Characterization of LGR5 stem cells in colorectal adenomas and carcinomas.Derivation of genetic biomarkers for cancer risk stratification in Barrett's oesophagus: a prospective cohort study.The human urothelium consists of multiple clonal units, each maintained by a stem cell.Modelling the evolution of genetic instability during tumour progression.
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description
hulumtues
@sq
onderzoeker
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researcher
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հետազոտող
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name
Trevor A Graham
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Trevor A Graham
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Trevor A Graham
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Trevor A Graham
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Trevor A Graham
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Trevor A Graham
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Trevor A Graham
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Trevor A Graham
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Trevor A Graham
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Trevor A Graham
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Trevor Graham
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Trevor A Graham
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Trevor A Graham
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Trevor A Graham
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Trevor A Graham
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Trevor A Graham
@sl
P106
P21
P31
P496
0000-0001-9582-1597