about
Mycobacterium tuberculosis dysregulates MMP/TIMP balance to drive rapid cavitation and unrestrained bacterial proliferationDissection of the host-pathogen interaction in human tuberculosis using a bioengineered 3-dimensional modelOptimisation of bioluminescent reporters for use with mycobacteriaComplex regulation of neutrophil-derived MMP-9 secretion in central nervous system tuberculosisHypoxia and tissue destruction in pulmonary TBEpigenetic Regulation of Matrix Metalloproteinase-1 and -3 Expression in Mycobacterium tuberculosis Infection.Gender-dependent differences in plasma matrix metalloproteinase-8 elevated in pulmonary tuberculosis.Membrane Type 1 Matrix Metalloproteinase Regulates Monocyte Migration and Collagen Destruction in Tuberculosis.Permutations of time and place in tuberculosisMycobacterium tuberculosis subverts negative regulatory pathways in human macrophages to drive immunopathology.Matrix metalloproteinases in tuberculosis.Vitamin D accelerates resolution of inflammatory responses during tuberculosis treatmentMycobacterium tuberculosis upregulates microglial matrix metalloproteinase-1 and -3 expression and secretion via NF-kappaB- and Activator Protein-1-dependent monocyte networks.Update in Mycobacterium tuberculosis lung disease 2014.Extremes of age are associated with indeterminate QuantiFERON-TB gold assay resultsAntimycobacterial drugs modulate immunopathogenic matrix metalloproteinases in a cellular model of pulmonary tuberculosis.STAT3, p38 MAPK, and NF-kappaB drive unopposed monocyte-dependent fibroblast MMP-1 secretion in tuberculosis.Doxycycline and HIV infection suppress tuberculosis-induced matrix metalloproteinases.The Extracellular Matrix Regulates Granuloma Necrosis in Tuberculosis.Tuberculosis, pulmonary cavitation, and matrix metalloproteinases.Controlled Generation of Microspheres Incorporating Extracellular Matrix Fibrils for Three-Dimensional Cell CultureInduced sputum MMP-1, -3 & -8 concentrations during treatment of tuberculosis.Ethnic variation in inflammatory profile in tuberculosis.MMP-1 drives immunopathology in human tuberculosis and transgenic mice.Induced sputum is safe and well-tolerated for TB diagnosis in a resource-poor primary healthcare settingNeutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary TuberculosisTranscriptional profiling of innate and adaptive human immune responses to mycobacteria in the tuberculin skin test.Structural and Functional Changes of the Invariant NKT Clonal Repertoire in Early Rheumatoid Arthritis.Cathepsin K Contributes to Cavitation and Collagen Turnover in Pulmonary TuberculosisCholesteryl esters stabilize human CD1c conformations for recognition by self-reactive T cells.Tuberculosis: time for a new perspective?Tuberculosis immunopathology: the neglected role of extracellular matrix destruction.Distinct emphysema subtypes defined by quantitative CT analysis are associated with specific pulmonary matrix metalloproteinases.In an in vitro model of human tuberculosis, monocyte-microglial networks regulate matrix metalloproteinase-1 and -3 gene expression and secretion via a p38 mitogen activated protein kinase-dependent pathwayProcollagen III N-terminal propeptide and desmosine are released by matrix destruction in pulmonary tuberculosisA Bioengineered Three-Dimensional Cell Culture Platform Integrated with Microfluidics To Address Antimicrobial Resistance in Tuberculosis.HIV-1 infection of macrophages dysregulates innate immune responses to Mycobacterium tuberculosis by inhibition of interleukin-10.Towards host-directed therapies for tuberculosis.Early Secretory Antigenic Target-6 Drives Matrix Metalloproteinase-10 Gene Expression and Secretion in TuberculosisMycobacterium tuberculosis-infected human monocytes down-regulate microglial MMP-2 secretion in CNS tuberculosis via TNFα, NFκB, p38 and caspase 8 dependent pathways.
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description
hulumtues
@sq
onderzoeker
@nl
researcher
@en
հետազոտող
@hy
name
Paul T Elkington
@nl
Paul T Elkington
@sl
Paul T. Elkington
@en
Paul T. Elkington
@es
type
label
Paul T Elkington
@nl
Paul T Elkington
@sl
Paul T. Elkington
@en
Paul T. Elkington
@es
prefLabel
Paul T Elkington
@nl
Paul T Elkington
@sl
Paul T. Elkington
@en
Paul T. Elkington
@es
P106
P1153
57194531731
P21
P31
P496
0000-0003-0390-0613