Kdm4b histone demethylase is a DNA damage response protein and confers a survival advantage following γ-irradiation. - Test2 - elhamkhani - TriplyDB

Kdm4b histone demethylase is a DNA damage response protein and confers a survival advantage following γ-irradiation.

Kdm4b histone demethylase is a DNA damage response protein and confers a survival advantage following γ-irradiation.

http://www.wikidata.org/entity/Q39142926

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PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair Hypoxia-Inducible Histone Lysine Demethylases: Impact on the Aging Process and Age-Related Diseases Histone demethylases in chromatin biology and beyond Metabolic modulation of chromatin: implications for DNA repair and genomic integrity The histone demethylase KDM4B regulates peritoneal seeding of ovarian cancer.2-Hydroxyglutarate produced by neomorphic IDH mutations suppresses homologous recombination and induces PARP inhibitor sensitivity.A macrohistone variant links dynamic chromatin compaction to BRCA1-dependent genome maintenance.Histone methylation and aging: lessons learned from model systems.Overexpression of KDM4 lysine demethylases disrupts the integrity of the DNA mismatch repair pathway.Solar Simulated Ultraviolet Radiation Induces Global Histone Hypoacetylation in Human Keratinocytes Depletion of Histone Demethylase Jarid1A Resulting in Histone Hyperacetylation and Radiation Sensitivity Does Not Affect DNA Double-Strand Break Repair.Identification of novel targets of diabetic nephropathy and PEDF peptide treatment using RNA-seq Analysis of the Histone H3.1 Interactome: A Suitable Chaperone for the Right Event.CITED2 silencing sensitizes cancer cells to cisplatin by inhibiting p53 trans-activation and chromatin relaxation on the ERCC1 DNA repair gene.KDM4A, KDM4B and KDM4C in non-small cell lung cancer.Integrated genomic and functional analyses of histone demethylases identify oncogenic KDM2A isoform in breast cancer.Skewed expression of the genes encoding epigenetic modifiers in high-risk uveal melanoma.Jumonji domain-containing protein 2B silencing induces DNA damage response via STAT3 pathway in colorectal cancer.Histone lysine demethylase (KDM) subfamily 4: structures, functions and therapeutic potential.Targeting chromatin to improve radiation response.Frapid: achieving full automation of FRAP for chemical probe validation Histone modifications in DNA damage response.H3K9me3 demethylase Kdm4d facilitates the formation of pre-initiative complex and regulates DNA replication.Biological function and regulation of histone and non-histone lysine methylation in response to DNA damage.NELF-E is recruited to DNA double-strand break sites to promote transcriptional repression and repair.The emerging role of lysine demethylases in DNA damage response: dissecting the recruitment mode of KDM4D/JMJD2D to DNA damage sites RNA-dependent chromatin localization of KDM4D lysine demethylase promotes H3K9me3 demethylation.KDM4C (GASC1) lysine demethylase is associated with mitotic chromatin and regulates chromosome segregation during mitosis.Radiation-induced alterations of histone post-translational modification levels in lymphoblastoid cell lines And yet, it moves: nuclear and chromatin dynamics of a heterochromatic double-strand break.KDM4D crosstalks with PARP1 and RNA at DNA DSBs.Silencing the epigenetic silencer KDM4A for TRAIL and DR5 simultaneous induction and antitumor therapy.Meta-analysis of DNA double-strand break response kinetics.Wild-type and mutated IDH1/2 enzymes and therapy responses.Histone demethylase KDM5A regulates the ZMYND8-NuRD chromatin remodeler to promote DNA repair.Hypoxia and Hormone-Mediated Pathways Converge at the Histone Demethylase KDM4B in Cancer.Reading chromatin signatures after DNA double-strand breaks.Recruitment of lysine demethylase 2A to DNA double strand breaks and its interaction with 53BP1 ensures genome stability.Histone methylation in DNA repair and clinical practice: new findings during the past 5-years.The JmjN domain as a dimerization interface and a targeted inhibitor of KDM4 demethylase activity.

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Kdm4b histone demethylase is a DNA damage response protein and confers a survival advantage following γ-irradiation.

http://www.wikidata.org/entity/Q39142926

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Kdm4b histone demethylase is a ...... ntage following γ-irradiation.

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Journal of Biological Chemistry

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Darin W McDonald

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Leah C Young

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Michael J Hendzel

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P2860

Hallmarks of Cancer: The Next Generation

RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites

Reversal of histone lysine trimethylation by the JMJD2 family of histone demethylases

Methylation of histone H3 lysine 36 enhances DNA repair by nonhomologous end-joining

Histone demethylation mediated by the nuclear amine oxidase homolog LSD1

Poly(ADP-ribose) polymerase 3 (PARP3), a newcomer in cellular response to DNA damage and mitotic progression

Epigenetic modifications in double-strand break DNA damage signaling and repair

Improved structure, function and compatibility for CellProfiler: modular high-throughput image analysis software

A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell

CellProfiler: image analysis software for identifying and quantifying cell phenotypes

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