Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function - Test2 - elhamkhani - TriplyDB

Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function

Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function

http://www.wikidata.org/entity/Q39239626

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The deubiquitylase USP33 discriminates between RALB functions in autophagy and innate immune response Rho GTPases, oxidation, and cell redox control Peeling away the layers of ubiquitin signaling complexities with synthetic ubiquitin-protein conjugates.Ras protein/cAMP-dependent protein kinase signaling is negatively regulated by a deubiquitinating enzyme, Ubp3, in yeast.RAS isoforms and mutations in cancer at a glance Non-degradative Ubiquitination of Protein Kinases.RASA3 is a critical inhibitor of RAP1-dependent platelet activation Guanine nucleotide-binding protein (Gα) endocytosis by a cascade of ubiquitin binding domain proteins is required for sustained morphogenesis and proper mating in yeast.The challenge of producing ubiquitinated proteins for structural studies When ubiquitination meets phosphorylation: a systems biology perspective of EGFR/MAPK signalling.Ral small GTPase signaling and oncogenesis: More than just 15minutes of fame Structurally distinct ubiquitin- and sumo-modified PCNA: implications for their distinct roles in the DNA damage response.OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination.Enzymatic production of mono-ubiquitinated proteins for structural studies: The example of the Josephin domain of ataxin-3.Differences in the regulation of K-Ras and H-Ras isoforms by monoubiquitination.Degradation of activated K-Ras orthologue via K-Ras-specific lysine residues is required for cytokinesis.Monoubiquitination is critical for ovarian tumor domain-containing ubiquitin aldehyde binding protein 1 (Otub1) to suppress UbcH5 enzyme and stabilize p53 protein.Chemical Protein Ubiquitylation with Preservation of the Native Cysteine Residues.SIRT2 deletion enhances KRAS-induced tumorigenesis in vivo by regulating K147 acetylation status.KRAS protein stability is regulated through SMURF2: UBCH5 complex-mediated β-TrCP1 degradation.Genomic instability and colon carcinogenesis: from the perspective of genes.Screening for E3-ubiquitin ligase inhibitors: challenges and opportunities.Ubiquitination in disease pathogenesis and treatment.Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function Chemical ubiquitination for decrypting a cellular code.Biological and Physicochemical Functions of Ubiquitylation Revealed by Synthetic Chemistry Approaches.Ubiquitylation Directly Induces Fold Destabilization of Proteins Nonspecific yet decisive: Ubiquitination can affect the native-state dynamics of the modified protein.New insights in the regulation of Rab GTPases by G protein-coupled receptors.Site-specific monoubiquitination downregulates Rab5 by disrupting effector binding and guanine nucleotide conversion A KRAS GTPase K104Q Mutant Retains Downstream Signaling by Offsetting Defects in Regulation.Ubiquitin ligases in oncogenic transformation and cancer therapy.RAS ubiquitylation modulates effector interactions.The Cullin-3-Rbx1-KCTD10 complex controls endothelial barrier function via K63 ubiquitination of RhoB.Functional significance and therapeutic implication of ring-type E3 ligases in colorectal cancer.

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P2860

Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function

http://www.wikidata.org/entity/Q39239626

description

2012 nî lūn-bûn

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

@zh-tw

2012年论文

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2012年论文

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2012年论文

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name

Site-specific monoubiquitinati ...... se-activating protein function

@en

Site-specific monoubiquitinati ...... e-activating protein function.

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type

label

Site-specific monoubiquitinati ...... se-activating protein function

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Site-specific monoubiquitinati ...... e-activating protein function.

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prefLabel

Site-specific monoubiquitinati ...... se-activating protein function

@en

Site-specific monoubiquitinati ...... e-activating protein function.

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Nature Structural & Molecular Biology

P1476

Site-specific monoubiquitinati ...... se-activating protein function

@en

P2093

Atsuo T Sasaki

http://www.w3.org/2001/XMLSchema#string

Brian Kuhlman

http://www.w3.org/2001/XMLSchema#string

Emily M Wilkerson

http://www.w3.org/2001/XMLSchema#string

Henrik G Dohlman

http://www.w3.org/2001/XMLSchema#string

Rachael Baker

http://www.w3.org/2001/XMLSchema#string

Sharon L Campbell

http://www.w3.org/2001/XMLSchema#string

Steven M Lewis

http://www.w3.org/2001/XMLSchema#string

P2860

Regulation of Rap2A by the ubiquitin ligase Nedd4-1 controls neurite development

Structural analysis of autoinhibition in the Ras activator Son of sevenless

The Ras-RasGAP complex: structural basis for GTPase activation and its loss in oncogenic Ras mutants

Solution structure of the PDZ2 domain from human phosphatase hPTP1E and its interactions with C-terminal peptides from the Fas receptor

Regional polysterism in the GTP-bound form of the human c-Ha-Ras protein

Backbone-dependent rotamer library for proteins. Application to side-chain prediction

Essential role for ubiquitin-ubiquitin-conjugating enzyme interaction in ubiquitin discharge from Cdc34 to substrate

ROSETTA3: an object-oriented software suite for the simulation and design of macromolecules

Small GTP-binding proteins

ras oncogenes in human cancer: a review

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46-52

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10.1038/NSMB.2430

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1

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20

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Lewis C. Cantley

Jason W. Locasale

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2012-11-25T00:00:00Z

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233768491

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23178454

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3537887

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