Pharmacokinetic drivers of toxicity for basic molecules: strategy to lower pKa results in decreased tissue exposure and toxicity for a small molecule Met inhibitor.
about
Preclinical trials for prevention of tumor progression of hepatocellular carcinoma by LZ-8 targeting c-Met dependent and independent pathways.Oxidation of heat shock protein 60 and protein disulfide isomerase activates ERK and migration of human hepatocellular carcinoma HepG2.The Therapeutic Targeting of HGF/c-Met Signaling in Hepatocellular Carcinoma: Alternative Approaches.Investigation of Acute and Chronic Toxicity Trends of Pesticides Using High-Throughput Bioluminescence Assay Based on the Test Organism Vibrio fischeri.Updates on the hepatocyte growth factor/c-Met axis in hepatocellular carcinoma and its therapeutic implications
P2860
Pharmacokinetic drivers of toxicity for basic molecules: strategy to lower pKa results in decreased tissue exposure and toxicity for a small molecule Met inhibitor.
description
2012 nî lūn-bûn
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2012年の論文
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2012年学术文章
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2012年学术文章
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2012年学术文章
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2012年学术文章
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name
Pharmacokinetic drivers of tox ...... small molecule Met inhibitor.
@en
Pharmacokinetic drivers of tox ...... small molecule Met inhibitor.
@nl
type
label
Pharmacokinetic drivers of tox ...... small molecule Met inhibitor.
@en
Pharmacokinetic drivers of tox ...... small molecule Met inhibitor.
@nl
prefLabel
Pharmacokinetic drivers of tox ...... small molecule Met inhibitor.
@en
Pharmacokinetic drivers of tox ...... small molecule Met inhibitor.
@nl
P2093
P1476
Pharmacokinetic drivers of tox ...... a small molecule Met inhibitor
@en
P2093
Bianca M Liederer
Daniel P Sutherlin
Dolores Diaz
Donna M Dambach
Dylan P Hartley
Edna F Choo
Eric B Harstad
Gary R Cain
John J Gaudino
P356
10.1016/J.TAAP.2012.10.026
P577
2012-11-07T00:00:00Z