Interdependent genotoxic mechanisms of monomethylarsonous acid: role of ROS-induced DNA damage and poly(ADP-ribose) polymerase-1 inhibition in the malignant transformation of urothelial cells
about
Methylarsonous acid causes oxidative DNA damage in cells independent of the ability to biomethylate inorganic arsenicGlobal gene expression changes in human urothelial cells exposed to low-level monomethylarsonous acid.Tumors and proliferative lesions in adult offspring after maternal exposure to methylarsonous acid during gestation in CD1 miceA Tox21 Approach to Altered Epigenetic Landscapes: Assessing Epigenetic Toxicity Pathways Leading to Altered Gene Expression and Oncogenic Transformation In VitroComparison of 2,2-bis(bromomethyl)-1,3-propanediol induced genotoxicity in UROtsa cells and primary rat hepatocytes: relevance of metabolism and oxidative stressMelanocytes and keratinocytes have distinct and shared responses to ultraviolet radiation and arsenic.Differential binding of monomethylarsonous acid compared to arsenite and arsenic trioxide with zinc finger peptides and proteins.Novel molecular targets for the therapy of urothelial carcinoma.Lupeol, a bioactive triterpene, prevents tumor formation during 7,12-dimethylbenz(a)anthracene induced oral carcinogenesis.Molecular insight of arsenic-induced carcinogenesis and its prevention.Knockout of arsenic (+3 oxidation state) methyltransferase is associated with adverse metabolic phenotype in mice: the role of sex and arsenic exposure.Arsenic-induced promoter hypomethylation and over-expression of ERCC2 reduces DNA repair capacity in humans by non-disjunction of the ERCC2-Cdk7 complex.Evaluation of gene expression changes in human primary uroepithelial cells following 24-hr exposures to inorganic arsenic and its methylated metabolites.Arjunolic Acid Improves the Serum Level of Vitamin B12 and Folate in the Process of the Attenuation of Arsenic Induced Uterine Oxidative Stress.Catalase has a key role in protecting cells from the genotoxic effects of monomethylarsonous acid: a highly active metabolite of arsenic.
P2860
Q28397241-F3A10512-525C-4A6A-AC76-C930E6B8538EQ35633033-C20DB8C6-4FA1-4BD8-B21F-195FB4BD2D7CQ36281917-ECEBB110-0830-45D1-B7B9-F038CDA93BE1Q36394208-38BF399E-BF9A-4715-99B6-DF5251958ED1Q37245894-48D5CE9B-4987-4B83-BB33-6D5FB62DB6E5Q37633714-3923FC22-6259-4F87-85BB-31D65DBFBE27Q37721696-7E7E9F18-6149-4A31-A718-3D37466A6932Q38003195-EA90389D-F3A5-4911-ADE0-5296AD9A0D8BQ38431421-DA60CC55-F497-4652-8D5E-0410E12E2A81Q39147365-8D004404-C8D4-4B9F-A9FC-B8384EE42CA1Q39184989-E4D46DD9-C5F2-470E-941C-0A82447E5F91Q42707122-96AADB7C-E624-4A8A-B84C-E118665BD9F4Q42714046-8769BAFD-BBB4-4EF6-8C11-EDE2FDA36F8DQ47715174-7791951E-6739-462C-B3AA-DC05F97E7027Q53108830-BA55F787-D5AF-4302-8656-FE5BAE0BC4AB
P2860
Interdependent genotoxic mechanisms of monomethylarsonous acid: role of ROS-induced DNA damage and poly(ADP-ribose) polymerase-1 inhibition in the malignant transformation of urothelial cells
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh
2011年學術文章
@zh-hant
name
Interdependent genotoxic mecha ...... OS-induced DNA damage and poly
@nl
Interdependent genotoxic mecha ...... sformation of urothelial cells
@en
type
label
Interdependent genotoxic mecha ...... OS-induced DNA damage and poly
@nl
Interdependent genotoxic mecha ...... sformation of urothelial cells
@en
prefLabel
Interdependent genotoxic mecha ...... OS-induced DNA damage and poly
@nl
Interdependent genotoxic mecha ...... sformation of urothelial cells
@en
P2093
P2860
P1476
Interdependent genotoxic mecha ...... sformation of urothelial cells
@en
P2093
A J Gandolfi
Christopher L Kuhlman
Jeannie M Camarillo
Matthew K Medeiros
Serrine S Lau
Shawn M Wnek
P2860
P356
10.1016/J.TAAP.2011.08.029
P577
2011-09-10T00:00:00Z