Neoplastic transformation by Notch requires nuclear localization
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Main roads to melanomaNotch signaling induces rapid degradation of achaete-scute homolog 1.Notch1 augments NF-kappaB activity by facilitating its nuclear retentionProteomic analysis of the mammalian nuclear pore complexp300 acts as a transcriptional coactivator for mammalian Notch-1EBNA2 and activated Notch induce expression of BATFGlucocorticoid and growth factor synergism requirement for Notch4 chromatin domain activationThe two tempos of nuclear pore complex evolution: highly adapting proteins in an ancient frozen structure.Phosphorylation by glycogen synthase kinase-3 beta down-regulates Notch activity, a link for Notch and Wnt pathwaysCharacterization of a high-molecular-weight Notch complex in the nucleus of Notch(ic)-transformed RKE cells and in a human T-cell leukemia cell line.Evidence for differential expression of Notch receptors and their ligands in melanocytic nevi and cutaneous malignant melanoma.Mutations in NOTCH2 in patients with Hajdu-Cheney syndrome.Complementation of human papillomavirus type 16 E6 and E7 by Jagged1-specific Notch1-phosphatidylinositol 3-kinase signaling involves pleiotropic oncogenic functions independent of CBF1;Su(H);Lag-1 activation.Gliotoxin Targets Nuclear NOTCH2 in Human Solid Tumor Derived Cell Lines In Vitro and Inhibits Melanoma Growth in Xenograft Mouse Model.Essential roles for ankyrin repeat and transactivation domains in induction of T-cell leukemia by notch1.Induction of cyclin D1 transcription and CDK2 activity by Notch(ic): implication for cell cycle disruption in transformation by Notch(ic).Activation of Notch1 signaling is required for beta-catenin-mediated human primary melanoma progression.Phosphorylation of Ser2078 modulates the Notch2 function in 32D cell differentiation.Notch activation is an early and critical event during T-Cell leukemogenesis in Ikaros-deficient miceThe proliferation of Drosophila in cancer research: a system for the functional characterization of tumor suppressors and oncogenes.The Drosophila importin-α3 is required for nuclear import of notch in vivo and it displays synergistic effects with notch receptor on cell proliferation.Growth suppression of pre-T acute lymphoblastic leukemia cells by inhibition of notch signaling.Identification and validation of Notch pathway activating compounds through a novel high-throughput screening method.Assembly of a Notch transcriptional activation complex requires multimerization.Hierarchical phosphorylation within the ankyrin repeat domain defines a phosphoregulatory loop that regulates Notch transcriptional activityClinicopathological significance of altered Notch signaling in extrahepatic cholangiocarcinoma and gallbladder carcinoma.Back signaling by the Nrg-1 intracellular domainNotch signaling in T-cell acute lymphoblastic leukemia.Drosophila Brat and Human Ortholog TRIM3 Maintain Stem Cell Equilibrium and Suppress Brain Tumorigenesis by Attenuating Notch Nuclear Transport.Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinasesRbpj conditional knockout reveals distinct functions of Notch4/Int3 in mammary gland development and tumorigenesisNuclear JAK2: form and function in cancer.Non-canonical notch signaling in cancer and immunity.The C-terminal PDZ-ligand of JAGGED1 is essential for cellular transformation.Heterokaryon technique for analysis of cell type-specific localization.NACK is an integral component of the Notch transcriptional activation complex and is critical for development and tumorigenesis.Decrease in Fas-induced apoptosis by the γ-secretase inhibitor is dependent on p75(NTR) in a glioblastoma cell line.Distinct spatial and molecular features of notch pathway assembly in regulatory T cells.NOTCH1 and NOTCH3 coordinate esophageal squamous differentiation through a CSL-dependent transcriptional network.Notch1 signaling is mediated by importins alpha 3, 4, and 7.
P2860
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P2860
Neoplastic transformation by Notch requires nuclear localization
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
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2000年學術文章
@zh-hant
name
Neoplastic transformation by Notch requires nuclear localization
@en
Neoplastic transformation by Notch requires nuclear localization.
@nl
type
label
Neoplastic transformation by Notch requires nuclear localization
@en
Neoplastic transformation by Notch requires nuclear localization.
@nl
prefLabel
Neoplastic transformation by Notch requires nuclear localization
@en
Neoplastic transformation by Notch requires nuclear localization.
@nl
P2860
P1476
Neoplastic transformation by Notch requires nuclear localization
@en
P2093
Capobianco AJ
Jeffries S
P2860
P304
P356
10.1128/MCB.20.11.3928-3941.2000
P407
P577
2000-06-01T00:00:00Z