In vitro and in vivo interaction of synthetic peroxide RBx11160 (OZ277) with piperaquine in Plasmodium models.
about
A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malariaA molecular mechanism for eflornithine resistance in African trypanosomesIsothermal microcalorimetry, a new tool to monitor drug action against Trypanosoma brucei and Plasmodium falciparumSynergistic Malaria Parasite Killing by Two Types of Plasmodial Surface Anion Channel InhibitorsCharacterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy ModelingA tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance.Fixed dose combination of arterolane and piperaquine: a newer prospect in antimalarial therapyThe lipophilic bullet hits the targets: medicinal chemistry of adamantane derivativesIdentification and deconvolution of cross-resistance signals from antimalarial compounds using multidrug-resistant Plasmodium falciparum strainsGenome profiling of sterol synthesis shows convergent evolution in parasites and guides chemotherapeutic attack.Piperaquine resistance is associated with a copy number variation on chromosome 5 in drug-pressured Plasmodium falciparum parasites.A CLAG3 mutation in an amphipathic transmembrane domain alters malaria parasite nutrient channels and confers leupeptin resistance.Ex vivo activity of the ACT new components pyronaridine and piperaquine in comparison with conventional ACT drugs against isolates of Plasmodium falciparum.Monoclonal Antibodies That Recognize the Alkylation Signature of Antimalarial Ozonides OZ277 (Arterolane) and OZ439 (Artefenomel).First-in-man safety and pharmacokinetics of synthetic ozonide OZ439 demonstrates an improved exposure profile relative to other peroxide antimalarials.Synergistic anti-malarial action of cryptolepine and artemisininsIdentification of New Human Malaria Parasite Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors by Pharmacophore and Structure-Based Virtual Screening.Role of known molecular markers of resistance in the antimalarial potency of piperaquine and dihydroartemisinin in vitro.In vitro and in vivo characterization of the antimalarial lead compound SSJ-183 in Plasmodium models.Fast in vitro methods to determine the speed of action and the stage-specificity of anti-malarials in Plasmodium falciparum.In vitro activity of anti-malarial ozonides against an artemisinin-resistant isolate.Introducing New Antimalarial Analogues of Chloroquine and Amodiaquine: A Narrative Review.Emerging drugs for malaria.Discovery and Characterization of ACT-451840: an Antimalarial Drug with a Novel Mechanism of Action.Probing the antimalarial mechanism of artemisinin and OZ277 (arterolane) with nonperoxidic isosteres and nitroxyl radicals.Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase.A new double-antibody sandwich ELISA targeting Plasmodium falciparum aldolase to evaluate anti-malarial drug sensitivity.Probing the Peroxycarbenium [3+2] Cycloaddition Reactions with 1,2-Disubstituted Ethylenes: Results and Insights.Potent antimalarial 1,2,4-trioxanes through perhydrolysis of epoxides.Interactions between artemisinins and other antimalarial drugs in relation to the cofactor model--a unifying proposal for drug action.Simple analogues of qinghaosu (artemisinin).Absence of association between piperaquine in vitro responses and polymorphisms in the pfcrt, pfmdr1, pfmrp, and pfnhe genes in Plasmodium falciparum.In vitro interaction of artemisinin derivatives or the fully synthetic peroxidic anti-malarial OZ277 with thapsigargin in Plasmodium falciparum strains.Safety, tolerability and pharmacokinetic profile of single and multiple oral doses of arterolane (RBx11160) maleate in healthy subjects.In vitro anti-malarial interaction and gametocytocidal activity of cryptolepine.
P2860
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P2860
In vitro and in vivo interaction of synthetic peroxide RBx11160 (OZ277) with piperaquine in Plasmodium models.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
In vitro and in vivo interacti ...... eraquine in Plasmodium models.
@en
In vitro and in vivo interaction of synthetic peroxide RBx11160
@nl
type
label
In vitro and in vivo interacti ...... eraquine in Plasmodium models.
@en
In vitro and in vivo interaction of synthetic peroxide RBx11160
@nl
prefLabel
In vitro and in vivo interacti ...... eraquine in Plasmodium models.
@en
In vitro and in vivo interaction of synthetic peroxide RBx11160
@nl
P2093
P1476
In vitro and in vivo interacti ...... eraquine in Plasmodium models.
@en
P2093
Christian Scheurer
Christopher Snyder
Josefina Santo-Tomas
P304
P356
10.1016/J.EXPPARA.2006.09.016
P577
2006-11-07T00:00:00Z