about
Structure and mechanism of the rebeccamycin sugar 4'-O-methyltransferase RebMExploiting the reversibility of natural product glycosyltransferase-catalyzed reactionsThe in vitro characterization of the iterative avermectin glycosyltransferase AveBI reveals reaction reversibility and sugar nucleotide flexibilityBiosynthesis of the C(7)-cyclitol moiety of acarbose in Actinoplanes species SE50/110. 7-O-phosphorylation of the initial cyclitol precursor leads to proposal of a new biosynthetic pathway.Recombinant E. coli prototype strains for in vivo glycorandomization.Diversifying vancomycin via chemoenzymatic strategies.Natural product diversification using a non-natural cofactor analogue of S-adenosyl-L-methionine.Deciphering indolocarbazole and enediyne aminodideoxypentose biosynthesis through comparative genomics: insights from the AT2433 biosynthetic locus.Minimum Information about a Biosynthetic Gene cluster.Activation and characterization of a cryptic gene cluster reveals a cyclization cascade for polycyclic tetramate macrolactams.Recent Advances in Discovery, Biosynthesis and Genome Mining of Medicinally Relevant Polycyclic Tetramate Macrolactams.Identification and characterization of a biosynthetic gene cluster for tryptophan dimers in deep sea-derived Streptomyces sp. SCSIO 03032.Characterization of the sugar-O-methyltransferase LobS1 in lobophorin biosynthesis.Mechanistic insights into polycycle formation by reductive cyclization in ikarugamycin biosynthesis.Pyrazolofluostatins A-C, Pyrazole-Fused Benzo[a]fluorenes from South China Sea-Derived Micromonospora rosaria SCSIO N160.Characterization of the flavoenzyme XiaK as an N-hydroxylase and implications in indolosesquiterpene diversification.Antimalarial β-carboline and indolactam alkaloids from Marinactinospora thermotolerans, a deep sea isolate.The acarbose-biosynthetic enzyme AcbO from Actinoplanes sp. SE 50/110 is a 2-epi-5-epi-valiolone-7-phosphate 2-epimerase.Identification of a 1-epi-valienol 7-kinase activity in the producer of acarbose, Actinoplanes sp. SE50/110.Penicacids A-C, three new mycophenolic acid derivatives and immunosuppressive activities from the marine-derived fungus Penicillium sp. SOF07.Genome Mining and Activation of a Silent PKS/NRPS Gene Cluster Direct the Production of Totopotensamides.Nocardiamides A and B, two cyclohexapeptides from the marine-derived actinomycete Nocardiopsis sp. CNX037.Tiacumicin Congeners with Improved Antibacterial Activity from a Halogenase-Inactivated Mutant.Identification and characterization of xiamycin A and oxiamycin gene cluster reveals an oxidative cyclization strategy tailoring indolosesquiterpene biosynthesis.Identification of caerulomycin A gene cluster implicates a tailoring amidohydrolase.Molecular basis of dimer formation during the biosynthesis of benzofluorene-containing atypical angucyclines.Characterization of a Sugar-O-methyltransferase TiaS5 Affords New Tiacumicin Analogues with Improved Antibacterial Properties and Reveals Substrate PromiscuityMarine Bacterial Aromatic Polyketides From Host-Dependent Heterologous Expression and Fungal Mode of CyclizationDiscovery of Stealthin Derivatives and Implication of the Amidotransferase FlsN3 in the Biosynthesis of Nitrogen-Containing FluostatinsAcyclic Congeners from Actinoalloteichus cyanogriseus Provide Insights into Cyclic Bipyridine Glycoside FormationBiosynthesis of himastatin: assembly line and characterization of three cytochrome P450 enzymes involved in the post-tailoring oxidative stepsEngineered Biosynthesis of 5/5/6 Type Polycyclic Tetramate Macrolactams in an Ikarugamycin (5/6/5 Type)-Producing ChassisDeciphering Biosynthetic Enzymes Leading to 4-Chloro-6-Methyl-5,7-Dihydroxyphenylglycine, a Non-Proteinogenic Amino Acid in TotopotensamidesCharacterizing Two Cytochrome P450s in Tiacumicin Biosynthesis Reveals Reaction Timing for Tailoring ModificationsProximicins F and G and Diproximicin A: Aminofurans from the Marine-Derived Verrucosispora sp. SCSIO 40062 by Overexpression of PPtase GenesDiscovery and Biosynthesis of Neoenterocins Indicate a Skeleton Rearrangement of EnterocinGenome Mining of Marine-Derived Streptomyces sp. SCSIO 40010 Leads to Cytotoxic New Polycyclic Tetramate MacrolactamsAlbumycin, a new isoindolequinone from Streptomyces albus J1074 harboring the fluostatin biosynthetic gene clusterHeterologous Expression Leads to Discovery of Diversified Lobophorin Analogues and a Flexible GlycosyltransferaseHeterologous expression of the trichostatin gene cluster and functional characterization of N-methyltransferase TsnB8
P50
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P50
description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Changsheng Zhang
@ast
Changsheng Zhang
@en
Changsheng Zhang
@es
Changsheng Zhang
@nl
Changsheng Zhang
@sl
type
label
Changsheng Zhang
@ast
Changsheng Zhang
@en
Changsheng Zhang
@es
Changsheng Zhang
@nl
Changsheng Zhang
@sl
prefLabel
Changsheng Zhang
@ast
Changsheng Zhang
@en
Changsheng Zhang
@es
Changsheng Zhang
@nl
Changsheng Zhang
@sl
P1053
B-5965-2012
P106
P2798
P31
P3829
P496
0000-0003-2349-3138