The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy.
about
C9orf72's Interaction with Rab GTPases-Modulation of Membrane Traffic and AutophagyMultiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulatorA C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagyLoss of C9orf72 Enhances Autophagic Activity via Deregulated mTOR and TFEB SignalingC9ORF72 hexanucleotide repeat exerts toxicity in a stable, inducible motor neuronal cell model, which is rescued by partial depletion of Pten.Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities?Protein Quality Control and the Amyotrophic Lateral Sclerosis/Frontotemporal Dementia ContinuumModelling amyotrophic lateral sclerosis: progress and possibilitiesSRSF1-dependent nuclear export inhibition of C9ORF72 repeat transcripts prevents neurodegeneration and associated motor deficits.Look who's talking-the crosstalk between oxidative stress and autophagy supports exosomal-dependent release of HCV particles.The essential and downstream common proteins of amyotrophic lateral sclerosis: A protein-protein interaction network analysis.Loss of C9orf72 function leads to autoimmunityModeling the C9ORF72 repeat expansion mutation using human induced pluripotent stem cells.Pathogenic determinants and mechanisms of ALS/FTD linked to hexanucleotide repeat expansions in the C9orf72 gene.Decoding ALS: from genes to mechanism.Rabs, Membrane Dynamics, and Parkinson's Disease.Could Sirtuin Activities Modify ALS Onset and Progression?Sec16 in conventional and unconventional exocytosis: Working at the interface of membrane traffic and secretory autophagy?Neurobiology of axonal transport defects in motor neuron diseases: Opportunities for translational research?C9orf72: At the intersection of lysosome cell biology and neurodegenerative disease.Mechanisms of Autophagy Initiation.Autophagy and Its Impact on Neurodegenerative Diseases: New Roles for TDP-43 and C9orf72.Multifaceted role of SMCR8 as autophagy regulator.RNA Misprocessing in C9orf72-Linked Neurodegeneration.C9ORF72 is a GDP/GTP exchange factor for Rab8 and Rab39 and regulates autophagy.The Enigmatic Role of C9ORF72 in AutophagyAutophagy Dysregulation in ALS: When Protein Aggregates Get Out of Hand.Proteostasis disturbance in amyotrophic lateral sclerosis.Autophagy-Independent Lysosomal Targeting Regulated by ULK1/2-FIP200 and ATG9.Endocytosis regulates TDP-43 toxicity and turnover.Is amyotrophic lateral sclerosis/frontotemporal dementia an autophagy disease?The emerging role of Rab GTPases in the pathogenesis of Parkinson's disease.Unaffected mosaic C9orf72 case: RNA foci, dipeptide proteins, but upregulated C9orf72 expression.Consequences of Rab GTPase dysfunction in genetic or acquired human diseases.The mammalian ULK1 complex and autophagy initiation.A proteomic network approach across the ALS-FTD disease spectrum resolves clinical phenotypes and genetic vulnerability in human brain.C9orf72 poly GA RAN-translated protein plays a key role in amyotrophic lateral sclerosis via aggregation and toxicity.Amyotrophic lateral sclerosis-associated mutant SOD1 inhibits anterograde axonal transport of mitochondria by reducing Miro1 levels.Current Advances and Limitations in Modeling ALS/FTD in a Dish Using Induced Pluripotent Stem Cells.Dysregulated molecular pathways in amyotrophic lateral sclerosis-frontotemporal dementia spectrum disorder.
P2860
Q28069365-5A9307D2-C7CB-4C3E-8BD4-9FE3F5679E7AQ28854564-85879FD4-7D92-4DF1-B6F0-116DB8314246Q29465530-F4428827-FA96-4FF0-A51A-D9AC30CEAF9BQ29465544-4D77A022-232C-450E-8D71-C26538889A34Q33614811-B0F5AA42-C219-4FBF-AD8E-DE9B9F4E82D6Q33621868-5667B9B4-EF22-4E5F-99D2-058C3DCA0632Q33653996-E14C46E7-6E92-4F82-8135-0495A21E9794Q33746289-F4D1FBE9-49DD-4B57-B2B4-7DD737972B3FQ33891056-6B518D71-296F-4CB6-BFD8-68DE5D2E36C7Q36227134-B902137D-423A-4345-AABB-CB8E5835B1A6Q36304197-20C215DD-AC56-4444-AB3F-7F1842963447Q37666980-5623131D-ADCD-4FB0-8B58-4B52B5BB825EQ38741408-B0773703-4536-49A4-88C0-FF80E3BE9F19Q38952327-ACBDBE84-B40F-4837-B69E-2840BDF00395Q39004348-D292C883-A568-483F-95F3-76D5342BD4F4Q39031304-6B6BFA21-48D5-46DD-86D8-ED389FD3F89EQ39036105-31CEE81B-E0F6-48C6-A7B5-682E369E08D4Q39119334-7AD1173A-452E-4ED4-B755-FA8693314D45Q39149919-DDA17F09-2D84-4A71-9AB5-B891FE23B35BQ39165154-8A528318-691E-49D8-93B1-6D605EDE0155Q39182119-9F059739-5F4D-4DBA-8675-1511AD28A6A1Q39370811-F9939FAC-00A5-4612-B170-1C60E180FDFBQ39428501-47CA1A39-64AE-4D98-B97D-3C82FBBD0C4BQ39458329-180C8658-29CE-4D4D-AADE-B3E72F31DF8FQ39520699-A44B07AA-222A-4A47-8AFE-EEA033EC4B1AQ41222674-6E4D55D8-FE2C-4BFB-B294-406E95AC75FDQ41525479-5C915625-C654-4157-BF29-C8DB525FEC30Q41991266-9B6D8F4E-5074-41A3-AD43-919604971B06Q42514504-07C5CA45-A875-4F87-A18C-7DF0838B416EQ47108096-6B95D290-207E-4183-BE30-974AD230E6CFQ47108927-B8A6CC48-9EC8-4E98-AE2F-583A9CA5230BQ47217972-6F9EDE20-D608-4983-B833-EBE1C77AC697Q47250883-110E3260-4350-454D-B42D-DB8FDA61680EQ47294747-23D2261A-42D4-42F6-9ECC-E7104A1B75EFQ47301180-55E04453-CC57-463A-B3DA-D8A5A2B92391Q47344945-AC3B9236-5E41-40CD-B23D-315FE812C274Q47707045-7C0A0560-19EF-4274-98C5-01CB45E88768Q47707422-C6DB0ED3-3DBD-46E8-9446-5303E3ED1722Q47868914-9700FF67-9969-4018-BF88-C4BE4E151C12Q47946104-AD4FC589-7526-4831-B0DC-E0D9C3DAEC1D
P2860
The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
The C9orf72 protein interacts ...... ulate initiation of autophagy.
@en
The C9orf72 protein interacts ...... ulate initiation of autophagy.
@nl
type
label
The C9orf72 protein interacts ...... ulate initiation of autophagy.
@en
The C9orf72 protein interacts ...... ulate initiation of autophagy.
@nl
prefLabel
The C9orf72 protein interacts ...... ulate initiation of autophagy.
@en
The C9orf72 protein interacts ...... ulate initiation of autophagy.
@nl
P2093
P2860
P50
P921
P356
P1433
P1476
The C9orf72 protein interacts ...... ulate initiation of autophagy.
@en
P2093
Adrian Higginbottom
Annekathrin Moller
Brian K Kaspar
Claudia S Bauer
Emma F Smith
Kathrin Meyer
Matthew J Walsh
P2860
P304
P356
10.15252/EMBJ.201694401
P407
P50
P5008
P577
2016-06-22T00:00:00Z