The herpes simplex virus type 2 R1 protein kinase (ICP10 PK) functions as a dominant regulator of apoptosis in hippocampal neurons involving activation of the ERK survival pathway and upregulation of the antiapoptotic protein Bag-1.
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The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathwaysMurine cytomegalovirus m41 open reading frame encodes a Golgi-localized antiapoptotic protein.HSV-2 regulates monocyte inflammatory response via the Fas/FasL pathwayRole of Fas/FasL in regulation of inflammation in vaginal tissue during HSV-2 infection.Lytic HSV-1 infection induces the multifunctional transcription factor Early Growth Response-1 (EGR-1) in rabbit corneal cellsIdentity of zinc finger nucleases with specificity to herpes simplex virus type II genomic DNA: novel HSV-2 vaccine/therapy precursorsValproic acid induces neuronal cell death through a novel calpain-dependent necroptosis pathway.Performance and use of a ribonucleotide reductase herpes simplex virus type-specific serological assay.Herpes simplex virus infection and apoptosis.Apoptosis and antigen receptor function in T and B cells following exposure to herpes simplex virusThe HSV-2 protein ICP10PK prevents neuronal apoptosis and loss of function in an in vivo model of neurodegeneration associated with glutamate excitotoxicity.H11/HspB8 and Its Herpes Simplex Virus Type 2 Homologue ICP10PK Share Functions That Regulate Cell Life/Death Decisions and Human DiseaseThe herpes simplex virus type 2 gene ICP10PK protects from apoptosis caused by nerve growth factor deprivation through inhibition of caspase-3 activation and XIAP up-regulation.The growth compromised HSV-2 mutant DeltaRR prevents kainic acid-induced apoptosis and loss of function in organotypic hippocampal culturesMulti-targeted neuroprotection by the HSV-2 gene ICP10PK includes robust bystander activity through PI3-K/Akt and/or MEK/ERK-dependent neuronal release of vascular endothelial growth factor and fractalkine.Langerhans cells and viral immunity.Inhibition of Bim enhances replication of varicella-zoster virus and delays plaque formation in virus-infected cells.Viruses and Langerhans cells.Viral serine/threonine protein kinasesChlamydia inhibit host cell apoptosis by inducing Bag-1 via the MAPK/ERK survival pathway.Infectious agents and neurodegeneration.Chlamydial antiapoptotic activity involves activation of the Raf/MEK/ERK survival pathway.Manipulation of apoptosis and necroptosis signaling by herpesvirusesΔPK oncolytic activity includes modulation of the tumour cell milieu.The oncolytic virus ΔPK has multimodal anti-tumor activity.The HSV-2 mutant DeltaPK induces melanoma oncolysis through nonredundant death programs and associated with autophagy and pyroptosis proteins.Cell type-specific induction and inhibition of apoptosis by Herpes Simplex virus type 2 ICP10.The vaccinia virus-stimulated mitogen-activated protein kinase (MAPK) pathway is required for virus multiplication.Human cytomegalovirus inhibits apoptosis involving upregulation of the antiapoptotic protein Bag-1.Suppression of extracellular signal-regulated kinase activity in herpes simplex virus 1-infected cells by the Us3 protein kinaseDeltaRR vaccination protects from KA-induced seizures and neuronal loss through ICP10PK-mediated modulation of the neuronal-microglial axis.Intranasal administration of the growth-compromised HSV-2 vector DeltaRR prevents kainate-induced seizures and neuronal loss in rats and mice.ICP10PK inhibits calpain-dependent release of apoptosis-inducing factor and programmed cell death in response to the toxin MPP+.Forced expression of the H11 heat shock protein can be regulated by DNA methylation and trigger apoptosis in human cells.Neonatal neuronal apoptosis after betamethasone administration in pregnant Wistar rats.
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The herpes simplex virus type 2 R1 protein kinase (ICP10 PK) functions as a dominant regulator of apoptosis in hippocampal neurons involving activation of the ERK survival pathway and upregulation of the antiapoptotic protein Bag-1.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
The herpes simplex virus type ...... e antiapoptotic protein Bag-1.
@en
The herpes simplex virus type 2 R1 protein kinase
@nl
type
label
The herpes simplex virus type ...... e antiapoptotic protein Bag-1.
@en
The herpes simplex virus type 2 R1 protein kinase
@nl
prefLabel
The herpes simplex virus type ...... e antiapoptotic protein Bag-1.
@en
The herpes simplex virus type 2 R1 protein kinase
@nl
P2093
P2860
P1433
P1476
The herpes simplex virus type ...... e antiapoptotic protein Bag-1.
@en
P2093
E F R Pereira
L Aurelian
P2860
P304
P356
10.1128/JVI.77.2.1292-1305.2003
P407
P577
2003-01-01T00:00:00Z