The tumor suppressor UCHL1 forms a complex with p53/MDM2/ARF to promote p53 signaling and is frequently silenced in nasopharyngeal carcinoma.
about
Chronic Inflammation Links Cancer and Parkinson's DiseaseEpigenetic disruption of cell signaling in nasopharyngeal carcinoma.Prognostic relevance of UCH-L1 and α-internexin in pancreatic neuroendocrine tumors.Epigenetic silencing of ADAMTS18 promotes cell migration and invasion of breast cancer through AKT and NF-κB signalingGenetic evolution of uveal melanoma guides the development of an inflammatory microenvironment.Cross-platform array screening identifies COL1A2, THBS1, TNFRSF10D and UCHL1 as genes frequently silenced by methylation in melanoma.Alterations of cell cycle control proteins SHP‑1/2, p16, CDK4 and cyclin D1 in radioresistant nasopharyngeal carcinoma cellsThe ubiquitin peptidase UCHL1 induces G0/G1 cell cycle arrest and apoptosis through stabilizing p53 and is frequently silenced in breast cancer.UCHL1 provides diagnostic and antimetastatic strategies due to its deubiquitinating effect on HIF-1α.Regulation of the DNA damage response by ubiquitin conjugation.Silencing of UCHL1 by CpG promoter hyper-methylation is associated with metastatic gastroenteropancreatic well-differentiated neuroendocrine (carcinoid) tumors.Candidate pathways and genes for nasopharyngeal carcinoma based on bioinformatics study.Comparative methylome analysis in solid tumors reveals aberrant methylation at chromosome 6p in nasopharyngeal carcinoma.Ubiquitin C-terminal hydrolase l1 in tumorigenesisShRNA-mediated silencing of the RFC3 gene suppress ovarian tumor cells proliferation.Exclusive Association of p53 Mutation with Super-High Methylation of Tumor Suppressor Genes in the p53 Pathway in a Unique Gastric Cancer Phenotype.The human cadherin 11 is a pro-apoptotic tumor suppressor modulating cell stemness through Wnt/β-catenin signaling and silenced in common carcinomas.Integrin α9 gene promoter is hypermethylated and downregulated in nasopharyngeal carcinoma.Role of growth arrest and DNA damage-inducible α in Akt phosphorylation and ubiquitination after mechanical stress-induced vascular injury.UCHL1 Is a Putative Tumor Suppressor in Ovarian Cancer Cells and Contributes to Cisplatin Resistance.The putative tumor activator ARHGEF3 promotes nasopharyngeal carcinoma cell pathogenesis by inhibiting cellular apoptosisThe emerging role of deubiquitinating enzymes in genomic integrity, diseases, and therapeuticsRole of DNA methylation in head and neck cancer.Could dysregulation of UPS be a common underlying mechanism for cancer and neurodegeneration? Lessons from UCHL1.Deubiquitylating enzymes and DNA damage response pathways.Single-cell RNA sequencing reveals an altered gene expression pattern as a result of CRISPR/cas9-mediated deletion of Gene 33/Mig6 and chronic exposure to hexavalent chromium in human lung epithelial cells.CpG methylation of ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) and P53 mutation pattern in sporadic colorectal cancer.Increased production of nitric oxide correlates with tumor growth in Algerian patients with nasopharyngeal carcinoma.Characterization of the nasopharyngeal carcinoma methylome identifies aberrant disruption of key signaling pathways and methylated tumor suppressor genes.L-GILZ binds p53 and MDM2 and suppresses tumor growth through p53 activation in human cancer cells.Ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) is a potential tumour suppressor in prostate cancer and is frequently silenced by promoter methylationFEZF2, a novel 3p14 tumor suppressor gene, represses oncogene EZH2 and MDM2 expression and is frequently methylated in nasopharyngeal carcinoma.Zinc-finger protein 331, a novel putative tumor suppressor, suppresses growth and invasiveness of gastric cancer.Frequent CpG methylation of ubiquitin carboxyl-terminal hydrolase 1 (UCHL1) in sporadic and hereditary Tunisian breast cancer patients: clinical significance.Overexpression of ubiquitin carboxyl terminal hydrolase-L1 enhances multidrug resistance and invasion/metastasis in breast cancer by activating the MAPK/Erk signaling pathway.Mammalian target of rapamycin complex 2 regulates inflammatory response to stress.Epigenetics of gastroenteropancreatic neuroendocrine tumors: A clinicopathologic perspective.Epigenomic characterization of a p53-regulated 3p22.2 tumor suppressor that inhibits STAT3 phosphorylation via protein docking and is frequently methylated in esophageal and other carcinomas.Ubiquitin C-terminal hydrolase isozyme L1 is associated with shelterin complex at interstitial telomeric sites.Ubiquitin carboxyl-terminal hydrolases: involvement in cancer progression and clinical implications.
P2860
Q26745344-1CA05AF1-1A75-4DD7-9ABE-1A4FA5BF45BDQ33579472-CF92D78E-4705-40A3-B622-1F36AFDF84F1Q33708663-4E465255-A915-455B-B4C1-D59D5AC6DC1BQ33775271-212638EC-CF85-4D07-BB06-DE7EFE5A245AQ33849590-8DBD41EE-C331-4791-BF67-45880128F1F5Q34058385-DB898820-5B23-4A31-B6D7-0A99AC19FDCBQ34105208-DD41C28A-D8F1-4BD9-AA5A-D15024962DCBQ34141646-C17EB68B-79D6-4328-AF8F-4A57D41CA520Q35050488-15AC0449-2262-47A0-8766-8055EE18E6EAQ35161624-03C3A0E3-6053-44DB-9CFA-62DB32ECB575Q35229834-F0F289E5-E289-40E5-BF35-860B3E35FABDQ35405950-377E6838-6987-4B42-BA24-F2233602715FQ35928927-7EE076F4-8AFC-4037-888A-77C27C1B999CQ36091119-096D5030-4DBB-454A-8347-E1919699E3F6Q36095110-9D89BF43-C0C0-492D-AF59-5368C8D825F3Q36136842-4481D775-861F-4398-A1F2-ECEED0E5EA5BQ36186624-CD8BC5D6-C417-40B7-A994-FE20CC6D21C8Q36544611-5974E483-7D48-4F40-8442-B939A5E8A9A8Q37149506-B1319E94-95F8-40A4-9975-C60381B1AD85Q37249509-134FDDDC-36DC-4849-B949-68D5D1D105DBQ37295516-6ABB143F-D61F-4E99-BB7A-D3A600DCBB24Q37517626-5E940E44-B03F-4C23-948E-608F31586B00Q38019157-CB3B33B5-A379-4EFB-BF61-DE878EF530B5Q38108538-CED8893C-B837-4BB7-A3B7-CB71BC344109Q38109871-38E5480A-2865-4DA2-8A24-C0CA35735BEEQ38688209-F8539672-DA66-4FA2-9AC7-38BBED9BE63EQ38855817-0F3C8D4F-BFCC-4169-BD31-119421EA67E3Q38917703-1C2FD345-AB71-46E7-92D8-0839C8D410FEQ38931940-F20D4991-11D7-4C03-B597-09E5DF012969Q38962094-33D76CEB-478F-43FA-B7B3-814C4CBD223BQ39019302-4C3781E3-BBF8-4C19-B6BE-98D1A6291C19Q39151547-B8970AB7-2BF1-4276-9B1C-15C69B975FAEQ39389232-E87C19AE-C437-4DE2-8814-D35FF5363AEAQ39533559-825A22BB-128D-42AB-9F25-F4A0B0C5F2BDQ40622076-426A5BB8-F6C5-497E-B7A7-E47FFD24C4F8Q41201843-492EF281-1405-4A1C-8950-E7EC8309A39FQ42115029-C94C75B7-7068-4A52-9CE3-574110B51EF6Q47103555-68356CB9-F3A1-46E9-8E9B-E7012F17F289Q47169349-17DF1A34-7F5D-4DD1-B1BA-D73406E0A15EQ47592158-AF03DB85-F2A7-453B-8E9E-96C1B42F49F6
P2860
The tumor suppressor UCHL1 forms a complex with p53/MDM2/ARF to promote p53 signaling and is frequently silenced in nasopharyngeal carcinoma.
description
2010 nî lūn-bûn
@nan
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
2010年论文
@zh
2010年论文
@zh-cn
name
The tumor suppressor UCHL1 for ...... d in nasopharyngeal carcinoma.
@en
The tumor suppressor UCHL1 for ...... d in nasopharyngeal carcinoma.
@nl
type
label
The tumor suppressor UCHL1 for ...... d in nasopharyngeal carcinoma.
@en
The tumor suppressor UCHL1 for ...... d in nasopharyngeal carcinoma.
@nl
prefLabel
The tumor suppressor UCHL1 for ...... d in nasopharyngeal carcinoma.
@en
The tumor suppressor UCHL1 for ...... d in nasopharyngeal carcinoma.
@nl
P2093
P50
P1476
The tumor suppressor UCHL1 for ...... ed in nasopharyngeal carcinoma
@en
P2093
Andrew van Hasselt
Fan Fong Poon
Mu-Sheng Zeng
Wei-Hua Jia
Yi-Xin Zeng
P304
P356
10.1158/1078-0432.CCR-09-3178
P407
P577
2010-04-15T00:00:00Z