Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor.
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Insulin protects islets from apoptosis via Pdx1 and specific changes in the human islet proteomeThe insulin-like growth factor-1 receptor is a negative regulator of nitric oxide bioavailability and insulin sensitivity in the endotheliumThe forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growthInsulin and IGF1 receptors are essential for XX and XY gonadal differentiation and adrenal development in miceGenetic deficiency of glycogen synthase kinase-3beta corrects diabetes in mouse models of insulin resistanceSequence variation in IGF1R is associated with differences in insulin levels in nondiabetic Old Order Amish.Glucagon-like peptide-1 increases beta-cell glucose competence and proliferation by translational induction of insulin-like growth factor-1 receptor expression.Insulin-like growth factor 1 physiology: lessons from mouse models.Insulin-like growth factor-I regulation of immune function: a potential therapeutic target in autoimmune diseases?SH2B1 regulation of energy balance, body weight, and glucose metabolism.The role of insulin-like growth factor-I and its binding proteins in glucose homeostasis and type 2 diabetes.Activation of the Reg family genes by pancreatic-specific IGF-I gene deficiency and after streptozotocin-induced diabetes in mouse pancreasGenetic analysis of type-1 insulin-like growth factor receptor signaling through insulin receptor substrate-1 and -2 in pancreatic beta cells.Diabetes in mice with selective impairment of insulin action in Glut4-expressing tissues.Insulin resistance and pancreatic beta cell failurePancreatic beta-cell failure in obese mice with human-like CMP-Neu5Ac hydroxylase deficiency.Insulin-like growth factor type 1 receptor signaling in the cells of oligodendrocyte lineage is required for normal in vivo oligodendrocyte development and myelination.Inactivation of arf-bp1 induces p53 activation and diabetic phenotypes in mice.The insulin-like growth factor system: towards clinical applications.When the usual insulin is just not enoughInsulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistanceTransgenic rescue of insulin receptor-deficient miceLegacy Effect of Foxo1 in Pancreatic Endocrine Progenitors on Adult β-Cell Mass and Function.Obesity and intestinal epithelial deletion of the insulin receptor, but not the IGF 1 receptor, affect radiation-induced apoptosis in colon.Disruption of growth factor receptor-binding protein 10 in the pancreas enhances β-cell proliferation and protects mice from streptozotocin-induced β-cell apoptosisPitfalls of PCR-based strategy for genotyping cre-loxP miceDisruption of Tsc2 in pancreatic beta cells induces beta cell mass expansion and improved glucose tolerance in a TORC1-dependent manner.Formation and regeneration of the endocrine pancreas.Expression of an activating mutation in the gene encoding the KATP channel subunit Kir6.2 in mouse pancreatic beta cells recapitulates neonatal diabetes.Mechanisms of disease: using genetically altered mice to study concepts of type 2 diabetesTransgenic expression of insulin-response element binding protein-1 in beta-cells reproduces type 2 diabetesGlucagon-like peptide-1 protects beta-cells against apoptosis by increasing the activity of an IGF-2/IGF-1 receptor autocrine loopGrowth factor control of pancreatic islet regeneration and functionThe role of liver-derived insulin-like growth factor-I.SH2B1 in β-cells regulates glucose metabolism by promoting β-cell survival and islet expansion.DHEA supplementation in ovariectomized rats reduces impaired glucose-stimulated insulin secretion induced by a high-fat diet.IRS2 and PTP1B: Two opposite modulators of hepatic insulin signalling.Modulation of β-cell function: a translational journey from the bench to the bedside.Insulin and GH-IGF-I axis: endocrine pacer or endocrine disruptor?Role of CCN5 (WNT1 inducible signaling pathway protein 2) in pancreatic islets.
P2860
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P2860
Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor.
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年学术文章
@wuu
2002年学术文章
@zh-cn
2002年学术文章
@zh-hans
2002年学术文章
@zh-my
2002年学术文章
@zh-sg
2002年學術文章
@yue
2002年學術文章
@zh
2002年學術文章
@zh-hant
name
Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor.
@en
Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor.
@nl
type
label
Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor.
@en
Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor.
@nl
prefLabel
Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor.
@en
Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor.
@nl
P2093
P2860
P50
P356
P1476
Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor.
@en
P2093
Manrico Morroni
Morris F White
Pedro L Herrera
Peter E Fisher
Saverio Cinti
Shouhong Xuan
Tadahiro Kitamura
Yoshiaki Kido
P2860
P304
P356
10.1172/JCI0215276
P407
P577
2002-10-01T00:00:00Z