A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells.
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HSP90 and HSP70: Implication in Inflammation Processes and Therapeutic Approaches for Myeloproliferative NeoplasmsHsp70 May Be a Molecular Regulator of Schistosome Host InvasionFunctional analysis of Hsp70 inhibitorsThe human HSP70 family of chaperones: where do we stand?Allostery in the Hsp70 chaperone proteinsHeat shock proteins and heat shock factor 1 in carcinogenesis and tumor development: an updateIdentification of Viral and Host Proteins That Interact with Murine Gammaherpesvirus 68 Latency-Associated Nuclear Antigen during Lytic Replication: a Role for Hsc70 in Viral ReplicationInhibition of inducible heat shock protein-70 (hsp72) enhances bortezomib-induced cell death in human bladder cancer cellsGeldanamycin-induced osteosarcoma cell death is associated with hyperacetylation and loss of mitochondrial pool of heat shock protein 60 (hsp60)Hsp70 Isoforms Are Essential for the Formation of Kaposi's Sarcoma-Associated Herpesvirus Replication and Transcription CompartmentsHsp70-Bag3 interactions regulate cancer-related signaling networksA novel Hsp70 inhibitor prevents cell intoxication with the actin ADP-ribosylating Clostridium perfringens iota toxinHSPA8/HSC70 chaperone protein: structure, function, and chemical targeting.Heat shock protein responses to aging and proteotoxicity in the olfactory bulb.A modified HSP70 inhibitor shows broad activity as an anticancer agent.Comprehensive fluorogenic derivatization-liquid chromatography/tandem mass spectrometry proteomic analysis of colorectal cancer cell to identify biomarker candidate.Heat shock protein 70 (hsp70) as an emerging drug target.The mammalian disaggregase machinery: Hsp110 synergizes with Hsp70 and Hsp40 to catalyze protein disaggregation and reactivation in a cell-free systemThe generation of purinome-targeted libraries as a means to diversify ATP-mimetic chemical classes for lead finding.HSPA1A-independent suppression of PARK2 C289G protein aggregation by human small heat shock proteinsIdentification of an allosteric small-molecule inhibitor selective for the inducible form of heat shock protein 70.HSP70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells.Molecular chaperones and regulation of tau quality control: strategies for drug discovery in tauopathies.Anti-inflammatory peptide regulates the supply of heat shock protein 70 monomers: implications for aging and age-related diseaseHeat shock protein 70-dependent protective effect of polaprezinc on acetylsalicylic acid-induced apoptosis of rat intestinal epithelial cells.NZ28-induced inhibition of HSF1, SP1 and NF-κB triggers the loss of the natural killer cell-activating ligands MICA/B on human tumor cells.Heat shock protein defenses in the neocortex and allocortex of the telencephalon.Hsp72 is targeted to the mitotic spindle by Nek6 to promote K-fiber assembly and mitotic progression.Identification of markers that functionally define a quiescent multiple myeloma cell sub-population surviving bortezomib treatmentCharacterization of Aes nuclear foci in colorectal cancer cells.A Chemical Biology Study of Human Pluripotent Stem Cells Unveils HSPA8 as a Key Regulator of PluripotencyModulation of expression of heat shock proteins and apoptosis by Flueggea leucopyrus (Willd) decoction in three breast cancer phenotypes.MEK guards proteome stability and inhibits tumor-suppressive amyloidogenesis via HSF1.The Chemical Biology of Molecular Chaperones--Implications for Modulation of ProteostasisSubcellular distribution of non-muscle myosin IIb is controlled by FILIP through Hsc70Schizophrenia-Associated hERG channel Kv11.1-3.1 Exhibits a Unique Trafficking Deficit that is Rescued Through Proteasome Inhibition for High Throughput ScreeningCotranslational response to proteotoxic stress by elongation pausing of ribosomes.Widespread regulation of translation by elongation pausing in heat shockMuscle-specific microRNA1 (miR1) targets heat shock protein 70 (HSP70) during dexamethasone-mediated atrophy.Chemical Tools to Investigate Mechanisms Associated with HSP90 and HSP70 in Disease.
P2860
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P2860
A novel, small molecule inhibitor of Hsc70/Hsp70 potentiates Hsp90 inhibitor induced apoptosis in HCT116 colon carcinoma cells.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年学术文章
@wuu
2009年学术文章
@zh-cn
2009年学术文章
@zh-hans
2009年学术文章
@zh-my
2009年学术文章
@zh-sg
2009年學術文章
@yue
2009年學術文章
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2009年學術文章
@zh-hant
name
A novel, small molecule inhibi ...... HCT116 colon carcinoma cells.
@en
A novel, small molecule inhibi ...... HCT116 colon carcinoma cells.
@nl
type
label
A novel, small molecule inhibi ...... HCT116 colon carcinoma cells.
@en
A novel, small molecule inhibi ...... HCT116 colon carcinoma cells.
@nl
prefLabel
A novel, small molecule inhibi ...... HCT116 colon carcinoma cells.
@en
A novel, small molecule inhibi ...... HCT116 colon carcinoma cells.
@nl
P2093
P50
P1476
A novel, small molecule inhibi ...... n HCT116 colon carcinoma cells
@en
P2093
Andrew J Massey
Antony Padfield
Christopher J Graham
Geraint L Francis
Helen Browne
James B Murray
Martin J Drysdale
Melanie Dopson
Mike Comer
P2888
P304
P356
10.1007/S00280-009-1194-3
P577
2009-12-13T00:00:00Z