about
Novel ageing-biomarker discovery using data-intensive technologiesAlpha tocopherol supplementation elevates plasma apolipoprotein A1 isoforms in normal healthy subjects.Dose-dependent modulation of the T cell proteome by ascorbic acid.Proteomic analysis of a noninvasive human model of acute inflammation and its resolution: the twenty-one day gingivitis model.A novel silicon membrane-based biosensing platform using distributive sensing strategy and artificial neural networks for feature analysis.An aqueous extract of Fagonia cretica induces DNA damage, cell cycle arrest and apoptosis in breast cancer cells via FOXO3a and p53 expression.Plasma antioxidant status, immunoglobulin g oxidation and lipid peroxidation in demented patients: relevance to Alzheimer disease and vascular dementia.Plasma levels of HDL and carotenoids are lower in dementia patients with vascular comorbidities.An almond-enriched diet increases plasma α-tocopherol and improves vascular function but does not affect oxidative stress markers or lipid levels.Biomarkers.Sulforaphane restores cellular glutathione levels and reduces chronic periodontitis neutrophil hyperactivity in vitroUrinary 8-oxo-2'-deoxyguanosine: redox regulation of DNA repair in vivo?Thiol redox homeostasis in neurodegenerative diseaseLack of association between glucocorticoid use and presence of the metabolic syndrome in patients with rheumatoid arthritis: a cross-sectional study.Is the generation of neo-antigenic determinants by free radicals central to the development of autoimmune rheumatoid disease?The use of proteomic techniques to explore the holistic effects of nutrients in vivo.Aberrant reactive oxygen and nitrogen species generation in rheumatoid arthritis (RA): causes and consequences for immune function, cell survival, and therapeutic intervention.The role of monocytes in atherosclerotic coronary artery disease.Stabilising cysteinyl thiol oxidation and nitrosation for proteomic analysis.Immunochemical detection of UV-induced DNA damage and repair.Designing liposomal adjuvants for the next generation of vaccines.Innovative biomarkers for predicting type 2 diabetes mellitus: relevance to dietary management of frailty in older adults.Nrf2 activation supports cell survival during hypoxia and hypoxia/reoxygenation in cardiomyoblasts; the roles of reactive oxygen and nitrogen species.Lipid (per) oxidation in mitochondria: an emerging target in the ageing process?Palmitate promotes monocyte atherogenicity via de novo ceramide synthesis.Mitochondrial superoxide anion radicals mediate induction of apoptosis in cardiac myoblasts exposed to chronic hypoxia.Metabolic memory effect of the saturated fatty acid, palmitate, in monocytes.A comparison of the apoptotic and cytotoxic effects of hexanedione derivatives on human non-neuronal lines and the neuroblastoma line SH-SY5Y.Cell passage-associated transient high oxygenation causes a transient decrease in cellular glutathione and affects T cell responses to apoptotic and mitogenic stimuli.Apoptotic and necrotic effects of hexanedione derivatives on the human neuroblastoma line SK-N-SH.C-reactive protein mediates CD11b expression in monocytes through the non-receptor tyrosine kinase, Syk, and calcium mobilization but not through cytosolic peroxides.The presence of ascorbate induces expression of brain derived neurotrophic factor in SH-SY5Y neuroblastoma cells after peroxide insult, which is associated with increased survival.LDL-lipids from patients with hypercholesterolaemia and Alzheimer's disease are inflammatory to microvascular endothelial cells: mitigation by statin interventionCeramide induces a loss in cytosolic peroxide levels in mononuclear cells.Gingipains from Porphyromonas gingivalis increase the chemotactic and respiratory burst-priming properties of the 77-amino-acid interleukin-8 variantThe anti-inflammatory actions of methotrexate are critically dependent upon the production of reactive oxygen species.Healthy ageing and depletion of intracellular glutathione influences T cell membrane thioredoxin-1 levels and cytokine secretion.Apoptotic cell-derived ICAM-3 promotes both macrophage chemoattraction to and tethering of apoptotic cells.Immunochemical detection of sequence-specific modifications to DNA induced by UV light.Free radicals and redox signalling in T-cells during chronic inflammation and ageing.
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P50
description
hulumtuese
@sq
researcher
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wetenschapper
@nl
հետազոտող
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name
Helen Griffith
@de
Helen Griffiths
@en
Helen R Griffiths
@ast
Helen R Griffiths
@es
Helen R Griffiths
@nl
Helen R Griffiths
@sl
type
label
Helen Griffith
@de
Helen Griffiths
@en
Helen R Griffiths
@ast
Helen R Griffiths
@es
Helen R Griffiths
@nl
Helen R Griffiths
@sl
altLabel
Helen R Griffiths
@en
prefLabel
Helen Griffith
@de
Helen Griffiths
@en
Helen R Griffiths
@ast
Helen R Griffiths
@es
Helen R Griffiths
@nl
Helen R Griffiths
@sl
P108
P1053
E-3453-2013
P106
P21
P31
P3829
P496
0000-0002-2666-2147