Inhibitory effects of Robo2 on nephrin: a crosstalk between positive and negative signals regulating podocyte structure. - Test2 - elhamkhani - TriplyDB

Inhibitory effects of Robo2 on nephrin: a crosstalk between positive and negative signals regulating podocyte structure.

Inhibitory effects of Robo2 on nephrin: a crosstalk between positive and negative signals regulating podocyte structure.

http://www.wikidata.org/entity/Q39870362

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Lower urinary tract development and disease Proteomic analysis of formalin-fixed paraffin-embedded glomeruli suggests depletion of glomerular filtration barrier proteins in two-kidney, one-clip hypertensive rats Review series: The cell biology of renal filtration.Mutations of the SLIT2-ROBO2 pathway genes SLIT2 and SRGAP1 confer risk for congenital anomalies of the kidney and urinary tract.New congenital anomalies of the kidney and urinary tract and outcomes in Robo2 mutant mice with the inserted piggyBac transposon.Genetics of Vesicoureteral Reflux.Human Induced Pluripotent Stem Cell-Derived Podocytes Mature into Vascularized Glomeruli upon Experimental Transplantation Promiscuity as a functional trait: intrinsically disordered regions as central players of interactomes.The importance of podocyte adhesion for a healthy glomerulus.An update: the role of Nephrin inside and outside the kidney.Are podocytes motile?Podocyte-actin dynamics in health and disease.Blocking peptides and molecular mimicry as treatment for kidney disease.Targeting NCK-Mediated Endothelial Cell Front-Rear Polarity Inhibits Neovascularization.SLIT2/ROBO2 signaling pathway inhibits nonmuscle myosin IIA activity and destabilizes kidney podocyte adhesion.Fifteen years of research on nephrin: what we still need to know.Characterization of the early molecular changes in the glomeruli of Cd151 -/- mice highlights induction of mindin and MMP-10.Identification of direct negative crosstalk between the SLIT2 and Bone Morphogenetic Protein-Gremlin signaling pathways.Low molecular weight heparin improves proteinuria in rats with L-NAME induced preeclampsia by decreasing the expression of nephrin, but not podocin.The role of Slit-Robo signaling in the regulation of tissue barriers.

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Inhibitory effects of Robo2 on nephrin: a crosstalk between positive and negative signals regulating podocyte structure.

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Inhibitory effects of Robo2 on ...... regulating podocyte structure.

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J.CELREP.2012.06.002

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Inhibitory effects of Robo2 on ...... regulating podocyte structure.

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Anna Pisarek-Horowitz

http://www.w3.org/2001/XMLSchema#string

David J Salant

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Dennis Brown

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Hang Wang

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Hila Milo Rasouly

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Iain A Drummond

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Lawrence B Holzman

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Margaret McLaughlin

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Qinggang Li

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Ramon G Bonegio

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P2860

Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux

Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes

SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site

Noninvasive assessment of antenatal hydronephrosis in mice reveals a critical role for Robo2 in maintaining anti-reflux mechanism

Repulsive axon guidance: Abelson and Enabled play opposing roles downstream of the roundabout receptor

Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway

Podocyte slit-diaphragm protein nephrin is linked to the actin cytoskeleton

Nephrin ectodomain engagement results in Src kinase activation, nephrin phosphorylation, Nck recruitment, and actin polymerization.

Inducible clustering of membrane-targeted SH3 domains of the adaptor protein Nck triggers localized actin polymerization.

Slit stimulation recruits Dock and Pak to the roundabout receptor and increases Rac activity to regulate axon repulsion at the CNS midline.

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10.1016/J.CELREP.2012.06.002

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