A novel human AlkB homologue, ALKBH8, contributes to human bladder cancer progression.
about
Crystal structure and RNA binding properties of the RNA recognition motif (RRM) and AlkB domains in human AlkB homolog 8 (ABH8), an enzyme catalyzing tRNA hypermodificationMammalian ALKBH8 possesses tRNA methyltransferase activity required for the biogenesis of multiple wobble uridine modifications implicated in translational decodingHuman AlkB homolog ABH8 Is a tRNA methyltransferase required for wobble uridine modification and DNA damage survivalHuman AlkB homologue 1 (ABH1) exhibits DNA lyase activity at abasic sitesHuman AlkB homologue 5 is a nuclear 2-oxoglutarate dependent oxygenase and a direct target of hypoxia-inducible factor 1α (HIF-1α)The AlkB domain of mammalian ABH8 catalyzes hydroxylation of 5-methoxycarbonylmethyluridine at the wobble position of tRNACodon-biased translation can be regulated by wobble-base tRNA modification systems during cellular stress responsesTransfer RNA methytransferases and their corresponding modifications in budding yeast and humans: activities, predications, and potential roles in human healthNoncoding RNAs in DNA repair and genome integrityMethylated nucleosides in tRNA and tRNA methyltransferasesModify or die?--RNA modification defects in metazoansNOX1 supports the metabolic remodeling of HepG2 cellstRNA biology charges to the frontActivation mode of the eukaryotic m2G10 tRNA methyltransferase Trm11 by its partner protein Trm112Mice lacking Alkbh1 display sex-ratio distortion and unilateral eye defects.Cyclooxygenase 2-dependent and independent activation of Akt through casein kinase 2α contributes to human bladder cancer cell survival.Submicroscopic interstitial deletion of chromosome 11q22.3 in a girl with mild mental retardation and facial dysmorphism: Case report.ROS generation via NOX4 and its utility in the cytological diagnosis of urothelial carcinoma of the urinary bladderALKBH3, a human AlkB homologue, contributes to cell survival in human non-small-cell lung cancer.The inferred cardiogenic gene regulatory network in the mammalian heart.Cellular dynamics of RNA modification.tRNA modifications regulate translation during cellular stress.Alkbh8 Regulates Selenocysteine-Protein Expression to Protect against Reactive Oxygen Species Damage.Insights into molecular plasticity in protein complexes from Trm9-Trm112 tRNA modifying enzyme crystal structure.Alkbh2 protects against lethality and mutation in primary mouse embryonic fibroblasts.Nucleic acid oxidation in DNA damage repair and epigeneticsTrm112, a Protein Activator of Methyltransferases Modifying Actors of the Eukaryotic Translational Apparatus.Reactive oxygen species-mediated therapeutic control of bladder cancer.Aiding and abetting roles of NOX oxidases in cellular transformation.DNA repair by reversal of DNA damage.The roles of Jumonji-type oxygenases in human disease.Understanding the biology of reactive oxygen species and their link to cancer: NADPH oxidases as novel pharmacological targets.Mechanistic studies on the application of DNA aptamers as inhibitors of 2-oxoglutarate-dependent oxygenases.Syndecan-1 (CD138) contributes to prostate cancer progression by stabilizing tumour-initiating cells.ALKBH2, a novel AlkB homologue, contributes to human bladder cancer progression by regulating MUC1 expression.Mitochondrial ROS control of cancer.Frequent down-regulation of hABH2 in gastric cancer and its involvement in growth of cancer cells.Differential induction of reactive oxygen species through Erk1/2 and Nox-1 by FK228 for selective apoptosis of oncogenic H-Ras-expressing human urinary bladder cancer J82 cells.N6-methyladenine: a potential epigenetic mark in eukaryotes.The DNA repair protein ALKBH2 mediates temozolomide resistance in human glioblastoma cells.
P2860
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P2860
A novel human AlkB homologue, ALKBH8, contributes to human bladder cancer progression.
description
2009 nî lūn-bûn
@nan
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
2009年论文
@zh
2009年论文
@zh-cn
name
A novel human AlkB homologue, ALKBH8, contributes to human bladder cancer progression.
@en
A novel human AlkB homologue, ALKBH8, contributes to human bladder cancer progression.
@nl
type
label
A novel human AlkB homologue, ALKBH8, contributes to human bladder cancer progression.
@en
A novel human AlkB homologue, ALKBH8, contributes to human bladder cancer progression.
@nl
prefLabel
A novel human AlkB homologue, ALKBH8, contributes to human bladder cancer progression.
@en
A novel human AlkB homologue, ALKBH8, contributes to human bladder cancer progression.
@nl
P2093
P1433
P1476
A novel human AlkB homologue, ALKBH8, contributes to human bladder cancer progression
@en
P2093
Kazutake Tsujikawa
Keiji Shimada
Mitsutoshi Nakamura
Motoyoshi Tanaka
Noboru Konishi
Satoshi Anai
Yukiteru Ouji
P304
P356
10.1158/0008-5472.CAN-08-3530
P407
P577
2009-03-17T00:00:00Z