Selective modulation of matrix metalloproteinase 9 (MMP-9) functions via exosite inhibition.
about
Heart failure with preserved ejection fraction: emerging drug strategiesCollagenolytic Matrix Metalloproteinase Activities toward Peptomeric Triple-Helical SubstratesBiochemistry and molecular biology of gelatinase B or matrix metalloproteinase-9 (MMP-9): the next decadeTumor cell-produced matrix metalloproteinase 9 (MMP-9) drives malignant progression and metastasis of basal-like triple negative breast cancer.NMR and bioinformatics discovery of exosites that tune metalloelastase specificity for solubilized elastin and collagen triple helices.Matrix metalloproteinases in tumorigenesis: an evolving paradigm.Identification of exosite-targeting inhibitors of anthrax lethal factor by high-throughput screeningCitrate synthase is a novel in vivo matrix metalloproteinase-9 substrate that regulates mitochondrial function in the postmyocardial infarction left ventricle.Development of a Förster resonance energy transfer assay for monitoring bacterial collagenase triple-helical peptidase activity.FRET-based and other fluorescent proteinase probes.Exosite interactions impact matrix metalloproteinase collagen specificities.New strategies for targeting matrix metalloproteinasesMatrix metalloproteinase inhibition by heterotrimeric triple-helical Peptide transition state analoguesRecruitment of Matrix Metalloproteinase-9 (MMP-9) to the Fibroblast Cell Surface by Lysyl Hydroxylase 3 (LH3) Triggers Transforming Growth Factor-β (TGF-β) Activation and Fibroblast DifferentiationComparison of metalloproteinase protein and activity profiling.Matrix metalloproteinases as breast cancer drivers and therapeutic targets.The history of matrix metalloproteinases: milestones, myths, and misperceptions.Identification of collagen binding domain residues that govern catalytic activities of matrix metalloproteinase-2 (MMP-2).Synthesis of Fmoc-Gly-Ile Phosphinic Pseudodipeptide: Residue Specific Conditions for Construction of Matrix Metalloproteinase Inhibitor Building BlocksMatrix metalloproteinases as input and output signals for post-myocardial infarction remodelingInterstitial collagen catabolism.Matrix metalloproteinase (MMP)-9: a proximal biomarker for cardiac remodeling and a distal biomarker for inflammation.Peptide-based selective inhibitors of matrix metalloproteinase-mediated activitiesMMP-9 signaling in the left ventricle following myocardial infarction.Identification of specific hemopexin-like domain residues that facilitate matrix metalloproteinase collagenolytic activity.Analysis of flavonoid-based pharmacophores that inhibit aggrecanases (ADAMTS-4 and ADAMTS-5) and matrix metalloproteinases through the use of topologically constrained peptide substrates.The role of collagen charge clusters in the modulation of matrix metalloproteinase activity.Chemical biology for understanding matrix metalloproteinase function.Synthesis and biological applications of collagen-model triple-helical peptides.Temporal and spatial expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases following myocardial infarction.Spinal cord injury induced neuropathic pain: Molecular targets and therapeutic approaches.Determining the Substrate Specificity of Matrix Metalloproteases using Fluorogenic Peptide Substrates.Peptide from the C-terminal domain of tissue inhibitor of matrix metalloproteinases-2 (TIMP-2) inhibits membrane activation of matrix metalloproteinase-2 (MMP-2).Matrix Metalloproteinases in Myocardial Infarction and Heart Failure.Efficient synthesis of Fmoc-protected phosphinic pseudodipeptides: Building blocks for the synthesis of matrix metalloproteinase inhibitors.Hydroxyproline-containing collagen analogs trigger the release and activation of collagen-sequestered proMMP-2 by competition with prodomain-derived peptide P33-42.Therapeutic Potential of Matrix Metalloproteinase Inhibition in Breast Cancer.Early matrix metalloproteinase-9 inhibition post-myocardial infarction worsens cardiac dysfunction by delaying inflammation resolution.Functional characterization of selective exosite-binding inhibitors of matrix metalloproteinase-13 (MMP-13) - experimental validation in human breast and colon cancer.Matrix Metalloproteinase-9 (MMP-9) as a Cancer Biomarker and MMP-9 Biosensors: Recent Advances
P2860
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P2860
Selective modulation of matrix metalloproteinase 9 (MMP-9) functions via exosite inhibition.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
2008年论文
@zh
2008年论文
@zh-cn
name
Selective modulation of matrix ...... ctions via exosite inhibition.
@en
type
label
Selective modulation of matrix ...... ctions via exosite inhibition.
@en
prefLabel
Selective modulation of matrix ...... ctions via exosite inhibition.
@en
P2093
P2860
P356
P1476
Selective modulation of matrix ...... ctions via exosite inhibition.
@en
P2093
Gregg B Fields
Janelle L Lauer-Fields
John K Whitehead
Keith Brew
Robert P Hammer
P2860
P304
20087-20095
P356
10.1074/JBC.M801438200
P407
P577
2008-05-22T00:00:00Z