LCAT can rescue the abnormal phenotype produced by the natural ApoA-I mutations (Leu141Arg)Pisa and (Leu159Arg)FIN.
about
Structural Insights into High Density Lipoprotein: Old Models and New FactsapoE3[K146N/R147W] acts as a dominant negative apoE form that prevents remnant clearance and inhibits the biogenesis of HDL.Activation of lecithin:cholesterol acyltransferase by HDL ApoA-I central helices.Molecular etiology of a dominant form of type III hyperlipoproteinemia caused by R142C substitution in apoE4Domains of apoE4 required for the biogenesis of apoE-containing HDL.Alteration of negatively charged residues in the 89 to 99 domain of apoA-I affects lipid homeostasis and maturation of HDL.A Systematic Investigation of Structure/Function Requirements for the Apolipoprotein A-I/Lecithin Cholesterol Acyltransferase Interaction Loop of High-density Lipoprotein.Three-dimensional models of HDL apoA-I: implications for its assembly and function.Dysfunctional HDL containing L159R ApoA-I leads to exacerbation of atherosclerosis in hyperlipidemic mice.Discrete roles of apoA-I and apoE in the biogenesis of HDL species: lessons learned from gene transfer studies in different mouse models.Role of the hydrophobic and charged residues in the 218-226 region of apoA-I in the biogenesis of HDLSignificance of the hydrophobic residues 225-230 of apoA-I for the biogenesis of HDL.In vivo tissue cholesterol efflux is reduced in carriers of a mutation in APOA1.Dysfunctional HDL in diabetes mellitus and its role in the pathogenesis of cardiovascular disease.
P2860
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P2860
LCAT can rescue the abnormal phenotype produced by the natural ApoA-I mutations (Leu141Arg)Pisa and (Leu159Arg)FIN.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
LCAT can rescue the abnormal p ...... 41Arg)Pisa and (Leu159Arg)FIN.
@en
type
label
LCAT can rescue the abnormal p ...... 41Arg)Pisa and (Leu159Arg)FIN.
@en
prefLabel
LCAT can rescue the abnormal p ...... 41Arg)Pisa and (Leu159Arg)FIN.
@en
P2093
P356
P1433
P1476
LCAT can rescue the abnormal p ...... 141Arg)Pisa and (Leu159Arg)FIN
@en
P2093
Adelina Duka
Angeliki Chroni
Dimitris Kardassis
P304
10713-10721
P356
10.1021/BI7003203
P407
P577
2007-08-21T00:00:00Z