Ubiquitin-independent proteasomal degradation of Fra-1 is antagonized by Erk1/2 pathway-mediated phosphorylation of a unique C-terminal destabilizer.
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Reversible interconversion and maintenance of mammary epithelial cell characteristics by the ligand-regulated EGFR system.RSK is a principal effector of the RAS-ERK pathway for eliciting a coordinate promotile/invasive gene program and phenotype in epithelial cells.The anti-apoptotic activity of BAG3 is restricted by caspases and the proteasome.An NF-kappaB-dependent role for JunB in the induction of proinflammatory cytokines in LPS-activated bone marrow-derived dendritic cells.High expression of Collagen Triple Helix Repeat Containing 1 (CTHRC1) facilitates progression of oesophageal squamous cell carcinoma through MAPK/MEK/ERK/FRA-1 activation.Emerging roles of ATF2 and the dynamic AP1 network in cancer.Transcriptional complexity and roles of Fra-1/AP-1 at the uPA/Plau locus in aggressive breast cancer.Old players with a newly defined function: Fra-1 and c-Fos support growth of human malignant breast tumors by activating membrane biogenesis at the cytoplasm.Molecular mechanisms of cigarette smoke-induced proliferation of lung cells and prevention by vitamin C.FRA-1 as a driver of tumour heterogeneity: a nexus between oncogenes and embryonic signalling pathways in cancer.Calcineurin mediates the gonadotropin-releasing hormone effect on expression of both subunits of the follicle-stimulating hormone through distinct mechanisms.A Phosphoproteomic Comparison of B-RAFV600E and MKK1/2 Inhibitors in Melanoma Cells.Epstein-Barr virus latent membrane protein 2A promotes invasion of nasopharyngeal carcinoma cells through ERK/Fra-1-mediated induction of matrix metalloproteinase 9Common and distinct mechanisms of different redox-active carcinogens involved in the transformation of mouse JB6P+ cells.JunB breakdown in mid-/late G2 is required for down-regulation of cyclin A2 levels and proper mitosisThe PKCθ pathway participates in the aberrant accumulation of Fra-1 protein in invasive ER-negative breast cancer cells.Naringenin targets ERK2 and suppresses UVB-induced photoaging.Signal-dependent fra-2 regulation in skeletal muscle reserve and satellite cells.Temporal production of the signaling lipid phosphatidic acid by phospholipase D2 determines the output of extracellular signal-regulated kinase signaling in cancer cellsThe FOS transcription factor family differentially controls trophoblast migration and invasion.Context-dependent resistance to proteolysis of intrinsically disordered proteins.A 19S proteasomal subunit cooperates with an ERK MAPK-regulated degron to regulate accumulation of Fra-1 in tumour cells.Fra-1 controls motility of bladder cancer cells via transcriptional upregulation of the receptor tyrosine kinase AXL.Anthrax lethal toxin rapidly reduces c-Jun levels by inhibiting c-Jun gene transcription and promoting c-Jun protein degradation.MLK3 regulates FRA-1 and MMPs to drive invasion and transendothelial migration in triple-negative breast cancer cells.Functions of Fos phosphorylation in bone homeostasis, cytokine response and tumourigenesis.Resistance to BET Bromodomain Inhibitors Is Mediated by Kinome Reprogramming in Ovarian Cancer.c-Fos proteasomal degradation is activated by a default mechanism, and its regulation by NAD(P)H:quinone oxidoreductase 1 determines c-Fos serum response kinetics.Heterodimerization with Jun family members regulates c-Fos nucleocytoplasmic traffic.Arachidonic acid-dependent gene regulation during preadipocyte differentiation controls adipocyte potential.Fra-1 regulation of Matrix Metallopeptidase-1 (MMP-1) in metastatic variants of MDA-MB-231 breast cancer cells.Specificity of phosphorylation responses to MAP kinase pathway inhibitors in melanoma cells.DUSP5 is methylated in CIMP-high colorectal cancer but is not a major regulator of intestinal cell proliferation and tumorigenesis.The AP-1 transcription factor FOSL1 causes melanocyte reprogramming and transformation.Fra‑1 enhances the radioresistance of colon cancer cells to X‑ray or C‑ion radiation.Integrin-uPAR signaling leads to FRA-1 phosphorylation and enhanced breast cancer invasion.Mechanistic regulation of epithelial-to-mesenchymal transition through RAS signaling pathway and therapeutic implications in human cancer.
P2860
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P2860
Ubiquitin-independent proteasomal degradation of Fra-1 is antagonized by Erk1/2 pathway-mediated phosphorylation of a unique C-terminal destabilizer.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Ubiquitin-independent proteaso ...... nique C-terminal destabilizer.
@en
type
label
Ubiquitin-independent proteaso ...... nique C-terminal destabilizer.
@en
prefLabel
Ubiquitin-independent proteaso ...... nique C-terminal destabilizer.
@en
P2093
P2860
P356
P1476
Ubiquitin-independent proteaso ...... nique C-terminal destabilizer.
@en
P2093
Dany Chalbos
Isabelle Jariel-Encontre
Jihane Basbous
Marc Piechaczyk
Robert Hipskind
P2860
P304
P356
10.1128/MCB.01776-06
P407
P577
2007-03-19T00:00:00Z