Suppressor of cytokine signaling 3 (SOCS3) limits damage-induced crypt hyper-proliferation and inflammation-associated tumorigenesis in the colon.
about
The role of small adaptor proteins in the control of oncogenic signalingr driven by tyrosine kinases in human cancerTissue communication in regenerative inflammatory signaling: lessons from the fly gutSOCS3: An essential physiological inhibitor of signaling by interleukin-6 and G-CSF family cytokinesSOCS, inflammation, and cancerThe role of suppressors of cytokine signalling in human neoplasmsMetformin Improves Ileal Epithelial Barrier Function in Interleukin-10 Deficient MiceChronic inflammation up-regulates P-gp in peripheral mononuclear blood cells via the STAT3/Nf-κb pathway in 2,4,6-trinitrobenzene sulfonic acid-induced colitis miceIL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancerMonocyte Subsets Coregulate Inflammatory Responses by Integrated Signaling through TNF and IL-6 at the Endothelial Cell Interface.Cyclophilin C-associated protein (CyCAP) knock-out mice spontaneously develop colonic mucosal hyperplasia and exaggerated tumorigenesis after treatment with carcinogen azoxymethane.IKK/NF-kappaB and STAT3 pathways: central signalling hubs in inflammation-mediated tumour promotion and metastasis.Suppressor of cytokine signaling 3 (SOCS3) is not an independent biomarker of colorectal adenoma risk.Murine models of colorectal cancer.Suppressor of cytokine signaling-2 gene disruption promotes Apc(Min/+) tumorigenesis and activator protein-1 activationEpimorphin deletion protects mice from inflammation-induced colon carcinogenesis and alters stem cell niche myofibroblast secretion.Stat3: linking inflammation to epithelial cancer - more than a "gut" feeling?Identification of SOCS2 and SOCS6 as biomarkers in human colorectal cancer.STAT3β controls inflammatory responses and early tumor onset in skin and colon experimental cancer models.The AOM/DSS murine model for the study of colon carcinogenesis: From pathways to diagnosis and therapy studiesIntestinal epithelial suppressor of cytokine signaling 3 enhances microbial-induced inflammatory tumor necrosis factor-α, contributing to epithelial barrier dysfunction.Kaposi's sarcoma-associated herpesvirus infection of endothelial cells inhibits neutrophil recruitment through an interleukin-6-dependent mechanism: a new paradigm for viral immune evasionβν integrin inhibits chronic and high level activation of JNK to repress senescence phenotypes in Drosophila adult midgut.STAT3-Activating Cytokines: A Therapeutic Opportunity for Inflammatory Bowel Disease?Cytokine induction of tumor necrosis factor receptor 2 is mediated by STAT3 in colon cancer cells.Cooperation between the bacterial-derived short-chain fatty acid butyrate and interleukin-22 detected in human Caco2 colon epithelial/carcinoma cells.Deletion of the SOCS box of suppressor of cytokine signaling 3 (SOCS3) in embryonic stem cells reveals SOCS box-dependent regulation of JAK but not STAT phosphorylation.The UPD3 cytokine couples environmental challenge and intestinal stem cell division through modulation of JAK/STAT signaling in the stem cell microenvironment.Cytokines, inflammation and colon cancerFXR induces SOCS3 and suppresses hepatocellular carcinoma.STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice.NF-kappaB and cancer-identifying targets and mechanisms.Drosophila Myc integrates multiple signaling pathways to regulate intestinal stem cell proliferation during midgut regeneration.Suppression of cytokine signaling: the SOCS perspective.Interleukin-6 promotes tumor progression in colitis-associated colorectal cancer through HIF-1α regulation.Mechanisms by which inflammation may increase intestinal cancer risk in inflammatory bowel disease.Inflammasomes in Inflammation-Induced Cancer.Intestinal inflammation and colorectal cancer: a double-edged sword?Stat3: linking inflammation to (gastrointestinal) tumourigenesis.Insulin-like growth factor 1: common mediator of multiple enterotrophic hormones and growth factors.Controlling the stem cell compartment and regeneration in vivo: the role of pluripotency pathways.
P2860
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P2860
Suppressor of cytokine signaling 3 (SOCS3) limits damage-induced crypt hyper-proliferation and inflammation-associated tumorigenesis in the colon.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Suppressor of cytokine signali ...... ed tumorigenesis in the colon.
@en
type
label
Suppressor of cytokine signali ...... ed tumorigenesis in the colon.
@en
prefLabel
Suppressor of cytokine signali ...... ed tumorigenesis in the colon.
@en
P2093
P356
P1433
P1476
Suppressor of cytokine signali ...... ed tumorigenesis in the colon.
@en
P2093
C J Greenhalgh
J G Simmons
W S Alexander
P2888
P304
P356
10.1038/SJ.ONC.1210286
P407
P577
2007-02-12T00:00:00Z
P5875
P6179
1049125524