Ras/ERK1/2-mediated STAT3 Ser727 phosphorylation by familial medullary thyroid carcinoma-associated RET mutants induces full activation of STAT3 and is required for c-fos promoter activation, cell mitogenicity, and transformation.
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Oncogenic RET Kinase Domain Mutations Perturb the Autophosphorylation Trajectory by Enhancing Substrate Presentation In transA role for fibrillar collagen deposition and the collagen internalization receptor endo180 in glioma invasion.Suppressor of cytokine signaling-2 gene disruption promotes Apc(Min/+) tumorigenesis and activator protein-1 activationGlial cell line-derived neurotrophic factor regulation of genes essential for self-renewal of mouse spermatogonial stem cells is dependent on Src family kinase signalingHeteroarylketones inhibit astroglial interleukin-6 expression via a STAT3/NF-κB signaling pathwayProtein kinase C epsilon regulation of translocator protein (18 kDa) Tspo gene expression is mediated through a MAPK pathway targeting STAT3 and c-Jun transcription factors.Alteration of EGFR spatiotemporal dynamics suppresses signal transduction.Comprehensive assessment of the disputed RET Y791F variant shows no association with medullary thyroid carcinoma susceptibility.Thyroid-specific ablation of the Carney complex gene, PRKAR1A, results in hyperthyroidism and follicular thyroid cancer.A common RET variant is associated with reduced newborn kidney size and functionNeurotrophic factor receptor RET: structure, cell biology, and inherited diseases.Complement anaphylatoxin C3a is a potent inducer of embryonic chick retina regeneration.Thyroid: Medullary Carcinoma.Molecular mechanisms of RET receptor-mediated oncogenesis in multiple endocrine neoplasia 2.Epstein-Barr virus latent membrane protein 1 induces expression of the epidermal growth factor receptor through effects on Bcl-3 and STAT3.The RET E616Q Variant is a Gain of Function Mutation Present in a Family with Features of Multiple Endocrine Neoplasia 2A.Serine-727 phosphorylation activates hypothalamic STAT-3 independently from tyrosine-705 phosphorylation.STAT3 and ERK1/2 cross-talk in leukaemia inhibitory factor mediated trophoblastic JEG-3 cell invasion and expression of mucin 1 and Fos.Mitochondrial STAT3 supports Ras-dependent oncogenic transformation.Functional characterization of a novel FGFR1OP-RET rearrangement in hematopoietic malignancies.The STAT3-Ser/Hes3 signaling axis: an emerging regulator of endogenous regeneration and cancer growth.Extracellular Signal-regulated Kinase Activation Is Required for Serine 727 Phosphorylation of STAT3 in Schwann Cells in vitro and in vivo.Scorpion Venom Causes Upregulation of p53 and Downregulation of Bcl-xL and BID Protein Expression by Modulating Signaling Proteins Erk(1/2) and STAT3, and DNA Damage in Breast and Colorectal Cancer Cell Lines.Paclitaxel treatment and PC1/3 knockdown in macrophages is a promising anti-glioma strategy as revealed by proteomics and cytotoxicity studies.Ras inhibition in hepatocarcinoma by S-trans-trans-farnesylthiosalicyclic acid: association of its tumor preventive effect with cell proliferation, cell cycle events, and angiogenesis.Intranuclear crosstalk between extracellular regulated kinase1/2 and signal transducer and activator of transcription 3 regulates JEG-3 choriocarcinoma cell invasion and proliferation.
P2860
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P2860
Ras/ERK1/2-mediated STAT3 Ser727 phosphorylation by familial medullary thyroid carcinoma-associated RET mutants induces full activation of STAT3 and is required for c-fos promoter activation, cell mitogenicity, and transformation.
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
2007年论文
@zh
2007年论文
@zh-cn
name
Ras/ERK1/2-mediated STAT3 Ser7 ...... ogenicity, and transformation.
@en
type
label
Ras/ERK1/2-mediated STAT3 Ser7 ...... ogenicity, and transformation.
@en
prefLabel
Ras/ERK1/2-mediated STAT3 Ser7 ...... ogenicity, and transformation.
@en
P2093
P2860
P356
P1476
Ras/ERK1/2-mediated STAT3 Ser7 ...... togenicity, and transformation
@en
P2093
Anthony I Magee
Bart J L Eggen
Charles H C M Buys
Harry Hollema
Iván Plaza-Menacho
Oliver Gimm
Tineke van der Sluis
P2860
P304
P356
10.1074/JBC.M608952200
P407
P577
2007-01-05T00:00:00Z