about
Predictive medicine: outcomes, challenges and opportunities in the Synergy-COPD projectConditional Disease Development extracted from Longitudinal Health Care Cohort Data using Layered Network Construction.A survey of best practices for RNA-seq data analysisA perspective on bridging scales and design of models using low-dimensional manifolds and data-driven model inferencePublic data and open source tools for multi-assay genomic investigation of diseaseBiomedical research in a Digital Health FrameworkData integration in the era of omics: current and future challengesA beta-mixture quantile normalization method for correcting probe design bias in Illumina Infinium 450 k DNA methylation data.The COPD Knowledge Base: enabling data analysis and computational simulation in translational COPD research.Assessing the consistency of public human tissue RNA-seq data sets.A comparative evaluation of data-merging and meta-analysis methods for reconstructing gene-gene interactionsFrom comorbidities of chronic obstructive pulmonary disease to identification of shared molecular mechanisms by data integration.STATegra EMS: an Experiment Management System for complex next-generation omics experiments.Oxygen pathway modeling estimates high reactive oxygen species production above the highest permanent human habitationWorkforce preparation: the Biohealth computing model for Master and PhD studentsSimulation environment and graphical visualization environment: a COPD use-case.ChainRank, a chain prioritisation method for contextualisation of biological networksAn integrative analysis reveals coordinated reprogramming of the epigenome and the transcriptome in human skeletal muscle after trainingImplementation of the CDC translational informatics platform--from genetic variants to the national Swedish Rheumatology Quality RegisterProposals for enhanced health risk assessment and stratification in an integrated care scenario.High-specificity bioinformatics framework for epigenomic profiling of discordant twins reveals specific and shared markers for ACPA and ACPA-positive rheumatoid arthritis.Chronic Obstructive Pulmonary Disease heterogeneity: challenges for health risk assessment, stratification and management.Guidelines for Developing Successful Short Advanced Courses in Systems Medicine and Systems Biology.From Systems Understanding to Personalized Medicine: Lessons and Recommendations Based on a Multidisciplinary and Translational Analysis of COPD.Cesarean delivery and hematopoietic stem cell epigenetics in the newborn infant: implications for future health?Comparison of the prevalence and distribution of human papillomavirus infection and cervical lesions between urban and native habitants of an Amazonian region of Peru.Hypermethylation of MIR21 in CD4+ T cells from patients with relapsing-remitting multiple sclerosis associates with lower miRNA-21 levels and concomitant up-regulation of its target genes.Assessment of health status and program performance in patients on long-term oxygen therapy.Workflow for generating competing hypothesis from models with parameter uncertainty.Reconciling coherent oscillation with modulation of irregular spiking activity in selective attention: gamma-range synchronization between sensory and executive cortical areas.An evaluation of analysis pipelines for DNA methylation profiling using the Illumina HumanMethylation450 BeadChip platform.Systems Medicine: from molecular features and models to the clinic in COPD.Monozygotic twins discordant for common variable immunodeficiency reveal impaired DNA demethylation during naïve-to-memory B-cell transition.Non-HLA genes PTPN22, CDK6 and PADI4 are associated with specific autoantibodies in HLA-defined subgroups of rheumatoid arthritis.Importance of mitochondrial P(O2) in maximal O2 transport and utilization: a theoretical analysis.ParkDB: a Parkinson's disease gene expression databaseFunctional genomics analysis of vitamin D effects on CD4+ T cells in vivo in experimental autoimmune encephalomyelitis .Erratum to: A comparative evaluation of data-merging and meta-analysis methods for reconstructing gene-gene interactionsErratum to: A survey of best practices for RNA-seq data analysis.Pre-B cell to macrophage transdifferentiation without significant promoter DNA methylation changes.
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David Gomez-Cabrero
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