about
Twenty proteins containing a C-terminal SOCS box form five structural classesAnkyrin repeat and suppressors of cytokine signaling box protein asb-9 targets creatine kinase B for degradationSOCS-6 binds to insulin receptor substrate 4, and mice lacking the SOCS-6 gene exhibit mild growth retardationFunctional analysis of Asb-1 using genetic modification in miceOncostatin M promotes bone formation independently of resorption when signaling through leukemia inhibitory factor receptor in miceThrombocytopenia and kidney disease in mice with a mutation in the C1galt1 geneThe biology and mechanism of action of suppressor of cytokine signaling 3An unusual cytokine:Ig-domain interaction revealed in the crystal structure of leukemia inhibitory factor (LIF) in complex with the LIF receptorThe SOCS Box Domain of SOCS3: Structure and Interaction with the ElonginBC-Cullin5 Ubiquitin LigaseSOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibitionThe dendritic cell receptor Clec9A binds damaged cells via exposed actin filamentsCrystal structure of the TRIM25 B30.2 (PRYSPRY) domain: a key component of antiviral signallingProduction of a human neutralizing monoclonal antibody and its crystal structure in complex with ectodomain 3 of the interleukin-13 receptor α1The pseudokinase MLKL mediates necroptosis via a molecular switch mechanismGrowth enhancement in suppressor of cytokine signaling 2 (SOCS-2)-deficient mice is dependent on signal transducer and activator of transcription 5b (STAT5b)The SOCS box: a tale of destruction and degradationDistinct roles for leukemia inhibitory factor receptor alpha-chain and gp130 in cell type-specific signal transductionSuppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signalingPoint mutation in the gene encoding p300 suppresses thrombocytopenia in Mpl-/- miceAffinity maturation of leukemia inhibitory factor and conversion to potent antagonists of signaling.A fusion protein system for the recombinant production of short disulfide-containing peptides.SH2 domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar binding specificities.Suppressor of Cytokine Signaling (SOCS) 5 utilises distinct domains for regulation of JAK1 and interaction with the adaptor protein Shc-1.A mutation in the translation initiation codon of Gata-1 disrupts megakaryocyte maturation and causes thrombocytopenia.Functional characterization of c-Mpl ectodomain mutations that underlie congenital amegakaryocytic thrombocytopenia.[Immuno-haematology and blood bank inventory and issue management].Cloning and characterization of a binding subunit of the interleukin 13 receptor that is also a component of the interleukin 4 receptorSuppressor screen in Mpl-/- mice: c-Myb mutation causes supraphysiological production of platelets in the absence of thrombopoietin signaling.Mechanistic insights into activation and SOCS3-mediated inhibition of myeloproliferative neoplasm-associated JAK2 mutants from biochemical and structural analysesReconstruction of an active SOCS3-based E3 ubiquitin ligase complex in vitro: identification of the active components and JAK2 and gp130 as substrates.Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1).Vaginally administered PEGylated LIF antagonist blocked embryo implantation and eliminated non-target effects on bone in mice.Crystal structure of the entire ectodomain of gp130: insights into the molecular assembly of the tall cytokine receptor complexesThe suppressors of cytokine signaling (SOCS) proteins: important feedback inhibitors of cytokine action.Deficiency of 5-hydroxyisourate hydrolase causes hepatomegaly and hepatocellular carcinoma in mice.Histidine-367 of the human common beta chain of the receptor is critical for high-affinity binding of human granulocyte-macrophage colony-stimulating factor.Localization of the human GM-CSF receptor gene to the X-Y pseudoautosomal region.IL-6 promotes acute and chronic inflammatory disease in the absence of SOCS3.Suppressor of cytokine signaling 4 (SOCS4) protects against severe cytokine storm and enhances viral clearance during influenza infection.Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130
P50
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Nicos A. Nicola
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Nicos A. Nicola
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Nicos A. Nicola
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Nicos A. Nicola
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Nicos A. Nicola
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Nicos A. Nicola
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Nicos A. Nicola
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Nicos A. Nicola
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Nicos A. Nicola
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Nicos A. Nicola
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P5361
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1950-01-01T00:00:00Z
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