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Antitumor-active cobalt-alkyne complexes derived from acetylsalicylic acid: studies on the mode of drug actionNew analgesics synthetically derived from the paracetamol metabolite N-(4-hydroxyphenyl)-(5Z,8Z,11Z,14Z)-icosatetra-5,8,11,14-enamide.A ruthenocene-PNA bioconjugate--synthesis, characterization, cytotoxicity, and AAS-detected cellular uptake.Organometallic anticancer compoundsPreclinical and clinical studies on the use of platinum complexes for breast cancer treatment.5-Alkynyl-2'-deoxyuridines: chromatography-free synthesis and cytotoxicity evaluation against human breast cancer cellsCobaltoceniumethynyl gold(I) as an unusual heterodinuclear bioorganometallic fragment to study the biological properties of alkynyl gold complexes.Anticancer and Antibacterial Activity Studies of Gold(I)-Alkynyl Chromones.Organotin complexes containing carboxylate ligands with maleimide and naphthalimide derived partial structures: TrxR inhibition, cytotoxicity and activity in resistant cancer cells.Gold(I) thiotetrazolates as thioredoxin reductase inhibitors and antiproliferative agents.A TrxR inhibiting gold(I) NHC complex induces apoptosis through ASK1-p38-MAPK signaling in pancreatic cancer cells.Detailed analysis of pro-apoptotic signaling and metabolic adaptation triggered by a N-heterocyclic carbene-gold(I) complex.Luminescent alkynyl-gold(I) coumarin derivatives and their biological activity.Analysis of the mechanism of action of potent antibacterial hetero-tri-organometallic compounds: a structurally new class of antibiotics.Butyltin(IV) benzoates: inhibition of thioredoxin reductase, tumor cell growth inhibition, and interactions with proteins.Comparative in vitro evaluation of N-heterocyclic carbene gold(I) complexes of the benzimidazolylidene type.From catalysts to bioactive organometallics: do Grubbs catalysts trigger biological effects?Fluorescence properties and antiproliferative effects of mono-, bis-, and tris- thiophenylnaphthalimides: results of a comparative pilot study.Highly cytotoxic substitutionally inert rhodium(III) tris(chelate) complexes: DNA binding modes and biological impact on human cancer cells.Benzimidazol-2-ylidene gold(I) complexes are thioredoxin reductase inhibitors with multiple antitumor properties.[Cyclopentadienyl]metalcarbonyl complexes of acetylsalicylic acid as neo-anticancer agents.Tuning the electronic properties of dppz-ligands and their palladium(II) complexes.Comparative biological evaluation of two ethylene linked mixed binuclear ferrocene/ruthenium organometallic species.Naphthalimide gold(I) phosphine complexes as anticancer metallodrugs.Synthesis and biological evaluation of chromium bioorganometallics based on the antibiotic platensimycin lead structure.Dinuclear organoiridium(III) mono- and bis-intercalators with rigid bridging ligands: synthesis, cytotoxicity and DNA binding.[N,N'-Bis(salicylidene)-1,2-phenylenediamine]metal complexes with cell death promoting properties.Structure-activity relationships and DNA binding properties of apoptosis inducing cytotoxic rhodium(III) polypyridyl complexes containing the cyclic thioether [9]aneS(3).Cytotoxic rhodium(III) and iridium(III) polypyridyl complexes: structure-activity relationships, antileukemic activity, and apoptosis induction.Sulfur-substituted naphthalimides as photoactivatable anticancer agents: DNA interaction, fluorescence imaging, and phototoxic effects in cultured tumor cells.Synthesis, cellular uptake and structure-activity relationships for potent cytotoxic trichloridoiridium(III) polypyridyl complexes.Metallo-nucleosides: synthesis and biological evaluation of hexacarbonyl dicobalt 5-alkynyl-2'-deoxyuridines.Synthesis and biological activities of novel dexibuprofen tetraacetylriboflavin conjugates.Gold(I) NHC Complexes: Antiproliferative Activity, Cellular Uptake, Inhibition of Mammalian and Bacterial Thioredoxin Reductases, and Gram-Positive Directed Antibacterial Effects.Development of cobalt(3,4-diarylsalen) complexes as tumor therapeutics.N-Heterocyclic carbene metal complexes in medicinal chemistry.Chronic treatment with losartan results in sufficient serum levels of the metabolite EXP3179 for PPARgamma activation.The plant decapeptide OSIP108 can alleviate mitochondrial dysfunction induced by cisplatin in human cells.A comparative chemical-biological evaluation of titanium(IV) complexes with a salan or cyclopentadienyl ligand.Evaluation of arene ruthenium(II) N-heterocyclic carbene complexes as organometallics interacting with thiol and selenol containing biomolecules.
P50
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հետազոտող
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Ingo Ott
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Ingo Ott
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Ingo Ott
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Ingo Ott
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Ingo Ott
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P106
P1153
7003382460
P21
P31
P496
0000-0002-8087-4618