PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1.
about
CRMP-2 is involved in kinesin-1-dependent transport of the Sra-1/WAVE1 complex and axon formationPar1b/MARK2 phosphorylates kinesin-like motor protein GAKIN/KIF13B to regulate axon formationThe Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesionThe PHCCEx domain of Tiam1/2 is a novel protein- and membrane-binding moduleThe keratin-binding protein Albatross regulates polarization of epithelial cellsRole of numb in dendritic spine development with a Cdc42 GEF intersectin and EphB2.Spatial regulation of CLASP affinity for microtubules by Rac1 and GSK3beta in migrating epithelial cellsCytoskeleton Molecular Motors: Structures and Their Functions in NeuronPolarity Determinants in Dendritic Spine Development and PlasticityThe on-off relationship of Rho and Rac during integrin-mediated adhesion and cell migrationRegulation of small GTPases by GEFs, GAPs, and GDIsPolarity in mammalian epithelial morphogenesisExtracellular and Intracellular Signaling for Neuronal PolarityRho GTPases at the crossroad of signaling networks in mammals: impact of Rho-GTPases on microtubule organization and dynamicsRho GTPases in collective cell migrationSubcellular optogenetic activation of Cdc42 controls local and distal signaling to drive immune cell migration.The Rac GTP exchange factor TIAM-1 acts with CDC-42 and the guidance receptor UNC-40/DCC in neuronal protrusion and axon guidanceThe Par-3 NTD adopts a PB1-like structure required for Par-3 oligomerization and membrane localizationThe Structure of the Tiam1 PDZ Domain/ Phospho-Syndecan1 Complex Reveals a Ligand Conformation that Modulates Protein DynamicsHigh-resolution structure of the Tiam1 PHn-CC-Ex domainThe Mammalian Blood-Testis Barrier: Its Biology and RegulationInvolvement of Girdin in the determination of cell polarity during cell migrationRegulation of lung endoderm progenitor cell behavior by miR302/367Shootin1: A protein involved in the organization of an asymmetric signal for neuronal polarizationLoss of aPKCĪ» in differentiated neurons disrupts the polarity complex but does not induce obvious neuronal loss or disorientation in mouse brainsIGF-1 receptor is essential for the establishment of hippocampal neuronal polarityProtein kinase Czeta and glycogen synthase kinase-3beta control neuronal polarity in developing rodent enteric neurons, whereas SMAD specific E3 ubiquitin protein ligase 1 promotes neurite growth but does not influence polarityThe polarity protein PAR-3 and TIAM1 cooperate in dendritic spine morphogenesisThe light chain 1 subunit of the microtubule-associated protein 1B (MAP1B) is responsible for Tiam1 binding and Rac1 activation in neuronal cellsThe insulin-like growth factor 1 receptor is essential for axonal regeneration in adult central nervous system neuronsTransient receptor potential canonical 5 channels activate Ca2+/calmodulin kinase Igamma to promote axon formation in hippocampal neuronsSingar1, a novel RUN domain-containing protein, suppresses formation of surplus axons for neuronal polarityTuberous sclerosis complex proteins control axon formationLoss of partitioning-defective-3/isotype-specific interacting protein (par-3/ASIP) in the elongating spermatid of RA175 (IGSF4A/SynCAM)-deficient micePar3 and dynein associate to regulate local microtubule dynamics and centrosome orientation during migrationRandom versus directionally persistent cell migrationOverexpression of atypical protein kinase C in HeLa cells facilitates macropinocytosis via Src activationDual function of partitioning-defective 3 in the regulation of YAP phosphorylation and activation.Signaling pathways in cell polarity.Phosphorylation of the par polarity complex protein Par3 at serine 962 is mediated by aurora a and regulates its function in neuronal polarity.
P2860
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P2860
PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1.
description
2005 nĆ® lÅ«n-bĆ»n
@nan
2005幓ć®č«ę
@ja
2005幓č«ę
@yue
2005幓č«ę
@zh-hant
2005幓č«ę
@zh-hk
2005幓č«ę
@zh-mo
2005幓č«ę
@zh-tw
2005幓č®ŗę
@wuu
2005幓č®ŗę
@zh
2005幓č®ŗę
@zh-cn
name
PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1.
@en
type
label
PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1.
@en
prefLabel
PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1.
@en
P2093
P2860
P356
P1433
P1476
PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam1.
@en
P2093
Katsuhiro Kato
Kozo Kaibuchi
Masato Yoshizawa
Mikio Hoshino
Takashi Nishimura
Tomoya Yamaguchi
Yo-ichi Nabeshima
P2860
P2888
P304
P356
10.1038/NCB1227
P50
P577
2005-02-20T00:00:00Z