Mutational analysis of narrow pores at the fivefold symmetry axes of adeno-associated virus type 2 capsids reveals a dual role in genome packaging and activation of phospholipase A2 activity
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Adeno-associated Virus as a Mammalian DNA VectorAdeno-associated virus: from defective virus to effective vectorStructure of a Packaging-Defective Mutant of Minute Virus of Mice Indicates that the Genome Is Packaged via a Pore at a 5-Fold AxisStructural Studies of Adeno-Associated Virus Serotype 8 Capsid Transitions Associated with Endosomal TraffickingStructural Insights into Adeno-Associated Virus Serotype 5Structure of neurotropic adeno-associated virus AAVrh.8.Green fluorescent protein-tagged adeno-associated virus particles allow the study of cytosolic and nuclear trafficking.Mutagenesis of adeno-associated virus type 2 capsid protein VP1 uncovers new roles for basic amino acids in trafficking and cell-specific transduction.Comparative analysis of adeno-associated virus capsid stability and dynamicsIn vitro and in vivo gene therapy vector evolution via multispecies interbreeding and retargeting of adeno-associated viruses.Depletion of virion-associated divalent cations induces parvovirus minute virus of mice to eject its genome in a 3'-to-5' direction from an otherwise intact viral particle.Intra- and inter-subunit disulfide bond formation is nonessential in adeno-associated viral capsidsVP2 cleavage and the leucine ring at the base of the fivefold cylinder control pH-dependent externalization of both the VP1 N terminus and the genome of minute virus of mice.Liver transduction with recombinant adeno-associated virus is primarily restricted by capsid serotype not vector genotype.Novel properties of tyrosine-mutant AAV2 vectors in the mouse retinaGene replacement therapies for duchenne muscular dystrophy using adeno-associated viral vectors.Gene therapy using adeno-associated virus vectorsStructure of an enteric pathogen, bovine parvovirusStructurally mapping the diverse phenotype of adeno-associated virus serotype 4.Mutations at the base of the icosahedral five-fold cylinders of minute virus of mice induce 3'-to-5' genome uncoating and critically impair entry functions.Isolation and Genomic Characterization of a Duck-Origin GPV-Related Parvovirus from Cherry Valley Ducklings in China.Four amino acids of an insect densovirus capsid determine midgut tropism and virulenceTyrosine cross-linking reveals interfacial dynamics in adeno-associated viral capsids during infectionMechanical elasticity as a physical signature of conformational dynamics in a virus particleMapping a neutralizing epitope onto the capsid of adeno-associated virus serotype 8.Surface loop dynamics in adeno-associated virus capsid assembly.Mapping Antigenic Epitopes on the Human Bocavirus Capsid.Recombinant adeno-associated virus utilizes host cell nuclear import machinery to enter the nucleusConformational changes in the VP1-unique region of native human parvovirus B19 lead to exposure of internal sequences that play a role in virus neutralization and infectivity.Structural Insights into Human Bocaparvoviruses.DNA Minicircle Technology Improves Purity of Adeno-associated Viral Vector Preparations.Human Parvoviruses.Adeno-associated virus type 2 capsids with externalized VP1/VP2 trafficking domains are generated prior to passage through the cytoplasm and are maintained until uncoating occurs in the nucleus.Impact of VP1-specific protein sequence motifs on adeno-associated virus type 2 intracellular trafficking and nuclear entry.Detection of intact rAAV particles up to 6 years after successful gene transfer in the retina of dogs and primates.Cryo-electron Microscopy Reconstruction and Stability Studies of the Wild Type and the R432A Variant of Adeno-associated Virus Type 2 Reveal that Capsid Structural Stability Is a Major Factor in Genome Packaging.Structure and dynamics of adeno-associated virus serotype 1 VP1-unique N-terminal domain and its role in capsid trafficking.Augmented transgene expression in transformed cells using a parvoviral hybrid vector.Surface-exposed adeno-associated virus Vp1-NLS capsid fusion protein rescues infectivity of noninfectious wild-type Vp2/Vp3 and Vp3-only capsids but not that of fivefold pore mutant virions.Low pH-dependent endosomal processing of the incoming parvovirus minute virus of mice virion leads to externalization of the VP1 N-terminal sequence (N-VP1), N-VP2 cleavage, and uncoating of the full-length genome.
P2860
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P2860
Mutational analysis of narrow pores at the fivefold symmetry axes of adeno-associated virus type 2 capsids reveals a dual role in genome packaging and activation of phospholipase A2 activity
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Mutational analysis of narrow ...... n of phospholipase A2 activity
@en
type
label
Mutational analysis of narrow ...... n of phospholipase A2 activity
@en
prefLabel
Mutational analysis of narrow ...... n of phospholipase A2 activity
@en
P2093
P2860
P1433
P1476
Mutational analysis of narrow ...... n of phospholipase A2 activity
@en
P2093
Florian Sonntag
Jürgen A Kleinschmidt
Svenja Bleker
P2860
P304
P356
10.1128/JVI.79.4.2528-2540.2005
P407
P577
2005-02-01T00:00:00Z