about
Structural characterization, kinetic studies, and in vitro biological activity of new cis-diamminebis-cholylglycinate(O,O') Pt(II) and cis-diamminebis-ursodeoxycholate(O,O') Pt(II) complexes.p,p-Dihydroxydihydrostilbenophanes related to antimitotic combretastatins. Conformational analysis and its relationship to tubulin inhibition.A new family of quinoline and quinoxaline analogues of combretastatins.Naphthylphenstatins as tubulin ligands: synthesis and biological evaluation.Isocombretastatins A: 1,1-diarylethenes as potent inhibitors of tubulin polymerization and cytotoxic compounds.Exploring the effect of 2,3,4-trimethoxy-phenyl moiety as a component of indolephenstatins.Biosynthesis of podophyllotoxin in Linum album cell cultures.Pyridine Based Antitumour Compounds Acting at the Colchicine Site.Exploring the size adaptability of the B ring binding zone of the colchicine site of tubulin with para-nitrogen substituted isocombretastatins.Endowing indole-based tubulin inhibitors with an anchor for derivatization: highly potent 3-substituted indolephenstatins and indoleisocombretastatins.Intrinsically fluorescent cytotoxic cisplatin analogues as DNA marker molecules.Further naphthylcombretastatins. An investigation on the role of the naphthalene moiety.Inotropic activity of hydroindene amidinohydrazones.Synthesis and cytotoxic activities of analogues of thuriferic acid.A fast and simple GC MS method for lignan profiling in Anthriscus sylvestris and biosynthetically related Plant species.Effects of 3-chloro-phenyl-1,4-dihydropyridine derivatives on Trypanosome cruzi epimastigotes.Physiological characteristics of allo-cholic acid.Naphthalene analogues of lignans.Anti-HIV activity of some synthetic lignanolides and intermediates.New naphthylcombretastatins. Modifications on the ethylene bridge.Diarylmethyloxime and hydrazone derivatives with 5-indolyl moieties as potent inhibitors of tubulin polymerization.Reactivity of 4-tert-butyldimethylsiloxy-1,2,3,6-tetrahydropyridines with hydrazines.Conformationally restricted macrocyclic analogues of combretastatins.Novel cationic and neutral glycocholic acid and polyamine conjugates able to inhibit transporters involved in hepatic and intestinal bile acid uptake.Inhibition of the intestinal absorption of bile acids using cationic derivatives: mechanism and repercussions.Novel bile acid derivatives (BANBs) with cytostatic activity obtained by conjugation of their side chain with nitrogenated bases.Synthesis and cytotoxic activity of different open indolocarbazole alkaloid analogues.Synthesis of Enantiopure 2,3,8,8a- Tetrahydro-7H-oxazolo[3,2-a]pyridine Derivatives†N-substituted pyrrolinones from enamines and α-dicarbonylsAntitubulin sulfonamides: The successful combination of an established drug class and a multifaceted targetLeishmanicidal activity of combretastatin analogues and heteroanaloguesTrypanosoma cruzi: Inhibition of Parasite Growth and Respiration by Oxazolo(thiazolo)pyridine Derivatives and Its Relationship to Redox Potential and LipophilicitySynthesis and Characterization of the New Cytostatic Complexcis-Diammineplatinum(II)−ChlorocholylglycinateSynthesis and biological activity of bromolignans and cyclolignansSynthesis, antitumoral and antiviral evaluation of halo- and demethyl-yatein derivativesHeterolignanolides: antitumor activity of furyl-, thienyl-, and pyridyl analogs of lignanolidesSynthesis and inotropic activity of hydroindene derivativesAntihypertensive activity of substituted 2,3,8,8a-tetrahydro-7H-oxazolo[3,2-a]pyridinedicarboxylate enantiomersOpen analogues of arcyriaflavin A. Synthesis through Diels-Alder reaction between maleimides and 1-aryl-3-tert-butyldimethylsiloxy-1, 3-butadienesSynthesis and pharmacological activity of diarylindole derivatives. Cytotoxic agents based on combretastatins
P50
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P50
description
hulumtues
@sq
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Manuel Medarde
@ast
Manuel Medarde
@en
Manuel Medarde
@es
Manuel Medarde
@nl
Manuel Medarde
@sl
type
label
Manuel Medarde
@ast
Manuel Medarde
@en
Manuel Medarde
@es
Manuel Medarde
@nl
Manuel Medarde
@sl
prefLabel
Manuel Medarde
@ast
Manuel Medarde
@en
Manuel Medarde
@es
Manuel Medarde
@nl
Manuel Medarde
@sl
P1053
L-3426-2014
P106
P1153
7005765694
P21
P31
P3829
P496
0000-0002-3311-5846