ABCA1 and amphipathic apolipoproteins form high-affinity molecular complexes required for cholesterol efflux.
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Apolipoprotein A-I activates Cdc42 signaling through the ABCA1 transporterDifferential phospholipid substrates and directional transport by ATP-binding cassette proteins ABCA1, ABCA7, and ABCA4 and disease-causing mutantsMammalian P4-ATPases and ABC transporters and their role in phospholipid transportThe interaction of ApoA-I and ABCA1 triggers signal transduction pathways to mediate efflux of cellular lipidsCysteine mutants of human apolipoprotein A-I: a study of secondary structural and functional propertiesATP-binding cassette transporters G1 and G4 mediate cellular cholesterol efflux to high-density lipoproteinsGene expression and biological processes influenced by deletion of Stat3 in pulmonary type II epithelial cells.Oxidation of apolipoprotein A-I by myeloperoxidase impairs the initial interactions with ABCA1 required for signaling and cholesterol exportMultimarker screening of oxidative stress in aging.ABCA1 promotes the efflux of bacterial LPS from macrophages and accelerates recovery from LPS-induced tolerance.Lipid-bound apolipoproteins in tyrosyl radical-oxidized HDL stabilize ABCA1 like lipid-free apolipoprotein A-ICarboxyl terminus of apolipoprotein A-I (ApoA-I) is necessary for the transport of lipid-free ApoA-I but not prelipidated ApoA-I particles through aortic endothelial cellsAn amphipathic helical region of the N-terminal barrel of phospholipid transfer protein is critical for ABCA1-dependent cholesterol efflux.ABCA8 stimulates sphingomyelin production in oligodendrocytes.Characteristics and functional relevance of apolipoprotein-A1 and cholesterol binding in mammary gland tissues and epithelial cellsABCA1 and nascent HDL biogenesisImpact of HDL oxidation by the myeloperoxidase system on sterol efflux by the ABCA1 pathwayRegulation of ABCA1 functions by signaling pathwaysHuman immunodeficiency virus protease inhibitor ritonavir inhibits cholesterol efflux from human macrophage-derived foam cells.ABCA1 and atherosclerosis.ABCA1-dependent sterol release: sterol molecule specificity and potential membrane domain for HDL biogenesis.Cholesterol is a determinant of the structures of discoidal high density lipoproteins formed by the solubilization of phospholipid membranes by apolipoprotein A-I.LXR Agonism Upregulates the Macrophage ABCA1/Syntrophin Protein Complex That Can Bind ApoA-I and Stabilized ABCA1 Protein, but Complex Loss Does Not Inhibit Lipid Efflux.Discrete roles of apoA-I and apoE in the biogenesis of HDL species: lessons learned from gene transfer studies in different mouse models.ABCA1 mutants reveal an interdependency between lipid export function, apoA-I binding activity, and Janus kinase 2 activation.The Role of Eukaryotic and Prokaryotic ABC Transporter Family in Failure of Chemotherapy.Molecules that mimic apolipoprotein A-I: potential agents for treating atherosclerosis.ABC transporters, atherosclerosis and inflammation.Lipid outward translocation by ABC proteins.ABC proteins protect the human body and maintain optimal health.Function and regulation of ABCA1--membrane meso-domain organization and reorganization.Lipid transport by mammalian ABC proteins.HDL quality and functionality: what can proteins and genes predict?Advances in high-density lipoprotein physiology: surprises, overturns, and promises.High-density lipoprotein (HDL) metabolism and bone mass.Sodium taurocholate-dependent lipid efflux by ABCA1: effects of W590S mutation on lipid translocation and apolipoprotein A-I dissociation.ABCA1-mediated cholesterol efflux generates microparticles in addition to HDL through processes governed by membrane rigidity.ATP hydrolysis-dependent conformational changes in the extracellular domain of ABCA1 are associated with apoA-I bindingNaturally occurring and bioengineered apoA-I mutations that inhibit the conversion of discoidal to spherical HDL: the abnormal HDL phenotypes can be corrected by treatment with LCAT.Janus kinase 2 modulates the lipid-removing but not protein-stabilizing interactions of amphipathic helices with ABCA1.
P2860
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P2860
ABCA1 and amphipathic apolipoproteins form high-affinity molecular complexes required for cholesterol efflux.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
ABCA1 and amphipathic apolipop ...... quired for cholesterol efflux.
@en
type
label
ABCA1 and amphipathic apolipop ...... quired for cholesterol efflux.
@en
prefLabel
ABCA1 and amphipathic apolipop ...... quired for cholesterol efflux.
@en
P2093
P2860
P1476
ABCA1 and amphipathic apolipop ...... equired for cholesterol efflux
@en
P2093
A J Mendez
A L Morris
M L Fitzgerald
M W Freeman
P2860
P304
P356
10.1194/JLR.M300355-JLR200
P577
2003-11-16T00:00:00Z