Central role of the proteasome in senescence and survival of human fibroblasts: induction of a senescence-like phenotype upon its inhibition and resistance to stress upon its activation.
about
HDACs and the senescent phenotype of WI-38 cells.Genetic Engineering of Mesenchymal Stem Cells to Induce Their Migration and SurvivalRole of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanismRedox control of protein degradationGlycated albumin: an overview of the In Vitro models of an In Vivo potential disease markerThe peptide methionine sulfoxide reductases, MsrA and MsrB (hCBS-1), are downregulated during replicative senescence of human WI-38 fibroblastsProteasome dysfunction in Drosophila signals to an Nrf2-dependent regulatory circuit aiming to restore proteostasis and prevent premature aging.PAC1 gene knockout reveals an essential role of chaperone-mediated 20S proteasome biogenesis and latent 20S proteasomes in cellular homeostasisPhage-displayed antibodies for the detection of glycated proteasome in aging cells.Role of proteasomes in disease.Proteasomes remain intact, but show early focal alteration in their composition in a mouse model of amyotrophic lateral sclerosis.Activation of proteasome by insulin-like growth factor-I may enhance clearance of oxidized proteins in the brain.Nuclear erythroid factor 2-mediated proteasome activation delays senescence in human fibroblasts.Mild heat stress stimulates 20S proteasome and its 11S activator in human fibroblasts undergoing aging in vitro.Effect of progerin on the accumulation of oxidized proteins in fibroblasts from Hutchinson Gilford progeria patients.Differential regulation of proteasome functionality in reproductive vs. somatic tissues of Drosophila during aging or oxidative stress.European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS).Proteasome inhibition modulates kinase activation in neural cells: relevance to ubiquitination, ribosomes, and survival.Protein homeostasis and aging: The importance of exquisite quality control.Autophagy impairment induces premature senescence in primary human fibroblasts.Transition of kidney tubule cells to a senescent phenotype in early experimental diabetes.Trehalose improves human fibroblast deficits in a new CHIP-mutation related ataxia.A novel role of proteasomal β1 subunit in tumorigenesis.Potential roles for ubiquitin and the proteasome during ribosome biogenesis.Oxidative stress-mediated regulation of proteasome complexes20S proteasome activation promotes life span extension and resistance to proteotoxicity in Caenorhabditis elegansA genome-wide longitudinal transcriptome analysis of the aging model Podospora anserina.Trehalose reverses cell malfunction in fibroblasts from normal and Huntington's disease patients caused by proteosome inhibition.Impairment of lon-induced protection against the accumulation of oxidized proteins in senescent wi-38 fibroblastsHexapeptide-11 is a novel modulator of the proteostasis network in human diploid fibroblastsImmunotherapy and immunoselection -- tumour escape as the final hurdle.Nrf2-dependent induction of proteasome and Pa28αβ regulator are required for adaptation to oxidative stressAging and regulated protein degradation: who has the UPPer hand?Senescence-Associated Changes in Proteome and O-GlcNAcylation Pattern in Human Peritoneal Mesothelial CellsBroad targeting of resistance to apoptosis in cancer.Protein oxidation and degradation during aging: role in skin aging and neurodegeneration.Maintenance of proteins and aging: the role of oxidized protein repair.Regulation of clusterin/apolipoprotein J, a functional homologue to the small heat shock proteins, by oxidative stress in ageing and age-related diseases.Oxidative stress adaptation with acute, chronic, and repeated stress.A scan for human-specific relaxation of negative selection reveals unexpected polymorphism in proteasome genes.
P2860
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P2860
Central role of the proteasome in senescence and survival of human fibroblasts: induction of a senescence-like phenotype upon its inhibition and resistance to stress upon its activation.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Central role of the proteasome ...... to stress upon its activation.
@en
type
label
Central role of the proteasome ...... to stress upon its activation.
@en
prefLabel
Central role of the proteasome ...... to stress upon its activation.
@en
P2093
P356
P1476
Central role of the proteasome ...... to stress upon its activation
@en
P2093
A Jennifer Rivett
Efstathios S Gonos
Fiona L L Stratford
Ioannis P Trougakos
Niki Chondrogianni
P304
28026-28037
P356
10.1074/JBC.M301048200
P407
P577
2003-05-07T00:00:00Z