Deconstruction of iterative multidomain polyketide synthase function. - Test2 - elhamkhani - TriplyDB

Deconstruction of iterative multidomain polyketide synthase function.

Deconstruction of iterative multidomain polyketide synthase function.

http://www.wikidata.org/entity/Q40794040

about

Biosynthesis of oxygen and nitrogen-containing heterocycles in polyketides Synthetic biology of fungal natural products Aflatoxin and deconstruction of type I, iterative polyketide synthase function Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis Next-generation sequencing approach for connecting secondary metabolites to biosynthetic gene clusters in fungi The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life Characterization of the biosynthetic genes for 10,11-dehydrocurvularin, a heat shock response-modulating anticancer fungal polyketide from Aspergillus terreus Insights into 6-Methylsalicylic Acid Bio-assembly by Using Chemical Probes Polyketide mimetics yield structural and mechanistic insights into product template domain function in nonreducing polyketide synthases Characterization of the Aspergillus nidulans monodictyphenone gene cluster.Structural enzymology of polyketide synthases.Acyltransferase mediated polyketide release from a fungal megasynthase Cyclization of aromatic polyketides from bacteria and fungi Classification, prediction, and verification of the regioselectivity of fungal polyketide synthase product template domains.Insights into radicicol biosynthesis via heterologous synthesis of intermediates and analogs Fungal polyketide engineering comes of age.Recent advancements in the biosynthetic mechanisms for polyketide-derived mycotoxins.Surveys of non-ribosomal peptide and polyketide assembly lines in fungi and prospects for their analysis in vitro and in vivo.Demonstration of starter unit interprotein transfer from a fatty acid synthase to a multidomain, nonreducing polyketide synthase.Penicillin's catalytic mechanism revealed by inelastic neutrons and quantum chemical theory.A genome-wide survey of the secondary metabolite biosynthesis genes in the wheat pathogen Parastagonospora nodorum.Hirsutellones and beyond: figuring out the biological and synthetic logics toward chemical complexity in fungal PKS-NRPS compounds.Allergens/Antigens, toxins and polyketides of important Aspergillus species.Unraveling polyketide synthesis in members of the genus Aspergillus New insights into the formation of fungal aromatic polyketides.Bioinformatical analysis of the sequences, structures and functions of fungal polyketide synthase product template domains.Starter unit flexibility for engineered product synthesis by the nonreducing polyketide synthase PksA In Vitro Reconstitution of Metabolic Pathways: Insights into Nature's Chemical Logic.Interrogation of global active site occupancy of a fungal iterative polyketide synthase reveals strategies for maintaining biosynthetic fidelity.Insights into 6-Methylsalicylic Acid Bio-assembly by Using Chemical Probes.Engineering of an "unnatural" natural product by swapping polyketide synthase domains in Aspergillus nidulans Illuminating the diversity of aromatic polyketide synthases in Aspergillus nidulans Evolution of Chemical Diversity in a Group of Non-Reduced Polyketide Gene Clusters: Using Phylogenetics to Inform the Search for Novel Fungal Natural Products.Identification and characterization of the chaetoviridin and chaetomugilin gene cluster in Chaetomium globosum reveal dual functions of an iterative highly-reducing polyketide synthase Analysis of the cercosporin polyketide synthase CTB1 reveals a new fungal thioesterase function Characterization of a fungal thioesterase having Claisen cyclase and deacetylase activities in melanin biosynthesis.Active site comparisons and catalytic mechanisms of the hot dog superfamily.Rational reprogramming of fungal polyketide first-ring cyclization Codinaeopsin, an antimalarial fungal polyketide.

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P2860

Deconstruction of iterative multidomain polyketide synthase function.

http://www.wikidata.org/entity/Q40794040

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2008 nî lūn-bûn

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Deconstruction of iterative multidomain polyketide synthase function.

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Deconstruction of iterative multidomain polyketide synthase function.

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Deconstruction of iterative multidomain polyketide synthase function.

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Deconstruction of iterative multidomain polyketide synthase function

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Craig A Townsend

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Jason M Crawford

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Jonathan R Scheerer

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Neil L Kelleher

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P2860

Polyketide chain length control by chain length factor

An antibiotic factory caught in action

Polyketide biosynthesis: a millennium review.

Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms.

Identification of a starter unit acyl-carrier protein transacylase domain in an iterative type I polyketide synthase

Starter unit specificity directs genome mining of polyketide synthase pathways in fungi.

A method for prediction of the locations of linker regions within large multifunctional proteins, and application to a type I polyketide synthase.

Cloning and characterization of a phosphopantetheinyl transferase from Streptomyces verticillus ATCC15003, the producer of the hybrid peptide-polyketide antitumor drug bleomycin.

Facile detection of acyl and peptidyl intermediates on thiotemplate carrier domains via phosphopantetheinyl elimination reactions during tandem mass spectrometry.

Engineered biosynthesis of novel polyketides.

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norsolorinate anthrone(2-)

norsolorinate(2-)

norsolorinic acid anthrone

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