Deconstruction of iterative multidomain polyketide synthase function.
about
Biosynthesis of oxygen and nitrogen-containing heterocycles in polyketidesSynthetic biology of fungal natural productsAflatoxin and deconstruction of type I, iterative polyketide synthase functionStructural basis for biosynthetic programming of fungal aromatic polyketide cyclizationStructure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesisNext-generation sequencing approach for connecting secondary metabolites to biosynthetic gene clusters in fungiThe phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for lifeCharacterization of the biosynthetic genes for 10,11-dehydrocurvularin, a heat shock response-modulating anticancer fungal polyketide from Aspergillus terreusInsights into 6-Methylsalicylic Acid Bio-assembly by Using Chemical ProbesPolyketide mimetics yield structural and mechanistic insights into product template domain function in nonreducing polyketide synthasesCharacterization of the Aspergillus nidulans monodictyphenone gene cluster.Structural enzymology of polyketide synthases.Acyltransferase mediated polyketide release from a fungal megasynthaseCyclization of aromatic polyketides from bacteria and fungiClassification, prediction, and verification of the regioselectivity of fungal polyketide synthase product template domains.Insights into radicicol biosynthesis via heterologous synthesis of intermediates and analogsFungal polyketide engineering comes of age.Recent advancements in the biosynthetic mechanisms for polyketide-derived mycotoxins.Surveys of non-ribosomal peptide and polyketide assembly lines in fungi and prospects for their analysis in vitro and in vivo.Demonstration of starter unit interprotein transfer from a fatty acid synthase to a multidomain, nonreducing polyketide synthase.Penicillin's catalytic mechanism revealed by inelastic neutrons and quantum chemical theory.A genome-wide survey of the secondary metabolite biosynthesis genes in the wheat pathogen Parastagonospora nodorum.Hirsutellones and beyond: figuring out the biological and synthetic logics toward chemical complexity in fungal PKS-NRPS compounds.Allergens/Antigens, toxins and polyketides of important Aspergillus species.Unraveling polyketide synthesis in members of the genus AspergillusNew insights into the formation of fungal aromatic polyketides.Bioinformatical analysis of the sequences, structures and functions of fungal polyketide synthase product template domains.Starter unit flexibility for engineered product synthesis by the nonreducing polyketide synthase PksAIn Vitro Reconstitution of Metabolic Pathways: Insights into Nature's Chemical Logic.Interrogation of global active site occupancy of a fungal iterative polyketide synthase reveals strategies for maintaining biosynthetic fidelity.Insights into 6-Methylsalicylic Acid Bio-assembly by Using Chemical Probes.Engineering of an "unnatural" natural product by swapping polyketide synthase domains in Aspergillus nidulansIlluminating the diversity of aromatic polyketide synthases in Aspergillus nidulansEvolution of Chemical Diversity in a Group of Non-Reduced Polyketide Gene Clusters: Using Phylogenetics to Inform the Search for Novel Fungal Natural Products.Identification and characterization of the chaetoviridin and chaetomugilin gene cluster in Chaetomium globosum reveal dual functions of an iterative highly-reducing polyketide synthaseAnalysis of the cercosporin polyketide synthase CTB1 reveals a new fungal thioesterase functionCharacterization of a fungal thioesterase having Claisen cyclase and deacetylase activities in melanin biosynthesis.Active site comparisons and catalytic mechanisms of the hot dog superfamily.Rational reprogramming of fungal polyketide first-ring cyclizationCodinaeopsin, an antimalarial fungal polyketide.
P2860
Q26738945-C99536F7-35FD-45D9-B468-D5B870A10FFFQ26797354-F6DDFC22-A8EF-4DF2-825F-4BB2861D7870Q26863697-5D37B3DA-5FF2-4E6E-BD32-2AF722721593Q27657897-3EAC8948-271B-4FFB-9C33-D0BD09ABA83FQ27660310-F75FA011-C907-4BBE-AF75-518BA5A7EC86Q28081722-EE2C7880-F2DE-4E20-A3D2-B330738627D1Q28659329-76225134-EE09-435B-95FB-CB6E7B8A0C97Q28704556-E4B29452-89D7-4C8C-A464-BCDDDA7840D3Q28829669-D04C218D-03E5-4649-AE07-72C353498869Q33737908-5F290142-EADF-460C-A402-1E67F06D81E6Q33768287-C65CE485-FA2F-45E8-A72B-2448E8BB4C5AQ33862817-E4A701E2-B82D-453A-BC5E-F670E68FA812Q33883904-4CD65964-04CC-4896-AEE0-DD78B9905E9BQ33910335-574240AE-743F-46D5-9C21-0D9880530B7BQ34003788-0D27A856-F346-4328-9C50-0CB6C9541AF2Q34024374-0D9A018A-A4D9-4E6F-8589-6C7BE7B9A4F6Q34120221-6E0BCA01-410B-4A34-999C-CA4B5ABE1C13Q34122684-06B0595D-A245-4189-AB45-7D4709D23F7AQ34249663-C5566532-518E-4274-B45B-1485BB9E56B6Q34341202-5503F10D-A7D1-4F26-9F28-2ED8E0ED7E4CQ34350426-01DAC219-38FF-49DD-96EC-899EF107120DQ34385351-0F86698A-8829-463C-B2CC-A51FBADBB24FQ34703730-0797BD12-4ACD-4FB8-97E7-5F496891CBD9Q35022360-51C58742-E338-4578-B018-C557882F7D43Q35032980-DBAC241F-8C78-49BA-AEC8-CE59633CA357Q35235074-5C0232DA-E346-480C-95E1-524031655EFCQ35637445-54856A0E-4BB5-4E84-9DF5-0945825F4796Q35846863-48C0022D-6EF2-492F-B498-0B0F5FD141AEQ35866989-99285FF7-8CA6-40F9-BEAF-D43249B63524Q35906588-E21331AD-7927-4DE9-AFF6-23EA97BFB2FAQ35911523-997B2949-154B-43E3-AB9B-2114AAFF92A6Q35954467-D38A8188-5123-4054-8152-7A62BF30C07EQ35977059-EAC77C56-99D6-46B4-B838-DCD46FA254F3Q36115211-2CF05F09-0B68-4A06-B487-B8D7F666BF7EQ36386489-81DF9EC7-461C-4F12-AA4E-76C2A9D43346Q36421477-3D5FB399-3655-48BF-8241-5EDB8907C57FQ36488484-C1335D32-70BB-4BC5-BD11-C080F3976A16Q36689982-E7836B71-15F4-4E96-8492-8D43BB74FB8DQ36747665-1CB9BC47-3CBE-4BE1-9070-27DCB99B107DQ37060557-8E061017-3D6E-44AD-987B-BE357035E21B
P2860
Deconstruction of iterative multidomain polyketide synthase function.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Deconstruction of iterative multidomain polyketide synthase function.
@en
type
label
Deconstruction of iterative multidomain polyketide synthase function.
@en
prefLabel
Deconstruction of iterative multidomain polyketide synthase function.
@en
P2093
P2860
P921
P356
P1433
P1476
Deconstruction of iterative multidomain polyketide synthase function
@en
P2093
Craig A Townsend
Jason M Crawford
Jonathan R Scheerer
Neil L Kelleher
P2860
P304
P356
10.1126/SCIENCE.1154711
P407
P577
2008-04-01T00:00:00Z