Human breast cancer cells contain elevated levels and activity of the protein kinase, PKR. - Test2 - elhamkhani - TriplyDB

Human breast cancer cells contain elevated levels and activity of the protein kinase, PKR.

Human breast cancer cells contain elevated levels and activity of the protein kinase, PKR.

http://www.wikidata.org/entity/Q40871190

about

Protein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3.Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action Double-stranded RNA-dependent protein kinase regulates the motility of breast cancer cells The role of PKR/eIF2α signaling pathway in prognosis of non-small cell lung cancer Double-stranded RNA-dependent protein kinase is involved in 2-methoxyestradiol-mediated cell death of osteosarcoma cells.Double-stranded RNA-dependent protein kinase-dependent apoptosis induction by a novel small compound.Pathway analysis using random forests with bivariate node-split for survival outcomes The 3'-untranslated regions of cytoskeletal muscle mRNAs inhibit translation by activating the double-stranded RNA-dependent protein kinase PKR.Increased expression of the dsRNA-activated protein kinase PKR in breast cancer promotes sensitivity to doxorubicin Molecular mechanism by which palmitate inhibits PKR autophosphorylation.OSU-03012 sensitizes breast cancers to lapatinib-induced cell killing: a role for Nck1 but not Nck2.Localization and function of a eukaryotic-initiation-factor-2-associated 67-kDa glycoprotein.Increased susceptibility of breast cancer cells to stress mediated inhibition of protein synthesis.IRES-mediated translation of cellular messenger RNA operates in eIF2α- independent manner during stress.Protein-Binding Function of RNA-Dependent Protein Kinase Promotes Proliferation through TRAF2/RIP1/NF-κB/c-Myc Pathway in Pancreatic β cells A Three Stage Integrative Pathway Search (TIPS) framework to identify toxicity relevant genes and pathways.PKR inhibits the DNA damage response, and is associated with poor survival in AML and accelerated leukemia in NHD13 mice.Implication of protein kinase R gene quantification in hepatitis C virus genotype 4 induced hepatocarcinogenesis.Up-regulation of a cellular protein at the translational level by a retrovirus.Increased expression of phosphorylated forms of RNA-dependent protein kinase and eukaryotic initiation factor 2alpha may signal skeletal muscle atrophy in weight-losing cancer patients Characterization of heterotypic interaction effects in vitro to deconvolute global gene expression profiles in cancer.Reduced eukaryotic initiation factor 2Bepsilon-subunit expression suppresses the transformed phenotype of cells overexpressing the protein.Repression of PKR mediates palmitate-induced apoptosis in HepG2 cells through regulation of Bcl-2.Cell death/proliferation roles for nc886, a non-coding RNA, in the protein kinase R pathway in cholangiocarcinoma.Hope and fear for interferon: the receptor-centric outlook on the future of interferon therapy.Smad7 knockdown activates protein kinase RNA-associated eIF2α pathway leading to colon cancer cell death.Quantitative chemical proteomics in small-scale culture of phorbol ester stimulated basal breast cancer cells.Identification of the PKR nuclear interactome reveals roles in ribosome biogenesis, mRNA processing and cell division.Anti-tumorigenic effects of Type 1 interferon are subdued by integrated stress responses.Mitochondrial dysfunction in cancer: Potential roles of ATF5 and the mitochondrial UPR.HDAC pharmacological inhibition promotes cell death through the eIF2α kinases PKR and GCN2.Doxorubicin bypasses the cytoprotective effects of eIF2α phosphorylation and promotes PKR-mediated cell death.Interferon-alpha induces sensitization of cells to inhibition of protein synthesis by tumour necrosis factor-related apoptosis-inducing ligand.Double-stranded RNA-dependent protein kinase, PKR, down-regulates CDC2/cyclin B1 and induces apoptosis in non-transformed but not in v-mos transformed cells.Double stranded RNA-dependent protein kinase promotes the tumorigenic phenotype in HepG2 hepatocellular carcinoma cells by activating STAT3.Expression of double-stranded RNA-activated protein kinase in keratinocytes and keratinocytic neoplasia.PKR negatively regulates leukemia progression in association with PP2A activation, Bcl-2 inhibition and increased apoptosis.Protein kinase R is increased and is functional in hepatitis C virus-related hepatocellular carcinoma.Activation of the interferon-inducible protein kinase PKR by hepatocellular carcinoma derived-hepatitis C virus core protein.Expression of double-stranded RNA-activated protein kinase in small-size peripheral adenocarcinoma of the lung.

P2860

Q24535156-D6C98919-7E60-4865-8B72-7E0716AE423B Q24672548-3D88E340-9BA9-4281-8D5C-BE1FAADDB103 Q28390155-4A2DD54B-9B94-4944-8028-126C34F2B1CC Q28742943-B0586B7F-26F6-4041-90B5-D5AE6FF3DF17 Q33259077-9665C4FC-EF4D-44A6-95DE-C9F7E21C89BB Q33391325-4CBB24B8-D06C-4F64-82A6-1673BF36C058 Q33581774-71FA8CD8-C161-495A-B092-810F63770F00 Q33583983-65A96C1C-DE54-41D7-A257-03E3040E0184 Q34430670-551B80DB-C0D9-4B8D-8616-19DCA1A7CCAA Q34561217-C9BE14E0-52C7-42C1-9673-C897AAD9DABF Q34739677-DD3C5D0F-59C0-41C7-A843-D3BFB508B95A Q34878502-0F912DAD-D6AA-454F-8AD5-FBED1899138A Q35560439-815A7C4A-D130-4460-B635-6FAECFAF10B2 Q35672175-BAD9DD41-AC29-4936-8EE0-BF2CC7342AE2 Q35707141-AA1957CA-76DE-4F7D-AC73-7A6855CA1C38 Q35869092-9BCD10DB-55A2-4829-AF35-289D1F3C6787 Q36091298-DD610318-96E1-4B4E-AEA9-EA65BFF74AB3 Q36367633-C3EF9A3F-74B2-4E62-817A-F223D5B9E7BD Q36535498-7C2C904F-5FF4-41B8-829A-594370CA10BB Q36614674-B7532565-3EF6-4F91-BF66-B2534F52DF85 Q36643285-EA05668D-1474-433C-8204-9BDE5C0A01CD Q37148762-07F82C69-F3DD-4F76-9AEB-464AEAB6C817 Q37149001-A1751EC6-3087-4E7E-9108-F1AF84FFE475 Q37407462-C0A03778-6BD2-42F7-B8E7-7583896EB8AF Q38097519-4E263604-CA7F-4BCB-8340-A3B48C9A823E Q38288682-754474FC-44F6-4F4A-9047-EDF474A98912 Q38502047-C7BF3E78-66FA-4995-B9F6-66C4B58DB784 Q39042417-3D7270C7-B58A-4D73-B81B-4B39E44A11A5 Q39264002-A5D50B89-8170-47A9-A062-54CBB3CC8288 Q39303215-FB6377B6-47D7-4AD6-9A9B-6C3CBC70F84D Q39631993-4DCA32E6-B0DE-4187-819B-D477811F0B2E Q39691249-AC1A55B0-82D1-4C11-B30D-410C5630423E Q40243488-EF3C2DB0-B388-425F-AA41-FBF5F1D2ED15 Q40758298-B1683C10-0394-42D5-878C-C88819ADD699 Q41682419-C1C213CE-C0AE-4616-93D3-8DED48AD8D02 Q42446367-4A911450-4476-4B01-BF05-D15442265659 Q42959284-C1D09247-ED80-4C39-853C-DEABF1A5C8DA Q42981519-6F3E7935-4EBB-49F1-96EA-949FD773BAEE Q43034820-22C9BAD2-6451-4043-B1F8-A275954603C9 Q47362441-E9051B4C-AB9A-465B-BC92-B5F2764E099D

P2860

Human breast cancer cells contain elevated levels and activity of the protein kinase, PKR.

http://www.wikidata.org/entity/Q40871190

description

2000 nî lūn-bûn

@nan

2000年の論文

@ja

2000年論文

@yue

2000年論文

@zh-hant

2000年論文

@zh-hk

2000年論文

@zh-mo

2000年論文

@zh-tw

2000年论文

@wuu

2000年论文

@zh

2000年论文

@zh-cn

name

Human breast cancer cells cont ...... ty of the protein kinase, PKR.

@en

type

label

Human breast cancer cells cont ...... ty of the protein kinase, PKR.

@en

prefLabel

Human breast cancer cells cont ...... ty of the protein kinase, PKR.

@en

P1433

Q40871190-2B3FB249-E9FC-4DE2-B9B1-408EA4960D34

P1476

Q40871190-E2002D70-8A13-432E-B2EA-9F3EEF34313C

P2093

Q40871190-0A2061F4-3999-4AF5-B600-C5DAF047DCCF

Q40871190-1AF5B2B1-37B7-45B7-B9E3-C29465C00CEC

Q40871190-20F9149A-42DA-4964-B75F-03644181557F

Q40871190-461EDA62-929A-4882-9EB1-7E0E8FB359CA

P2860

Q40871190-07C480A3-FD21-41E0-82A7-3C0892516F7D

Q40871190-1ADEC0EB-3DE0-4878-BFD0-E1AAD62B5B8F

Q40871190-275A38F8-55B3-44E1-A175-8B0B39926268

Q40871190-27D4E550-A1FE-483B-A9BE-EC455C1EE9AB

Q40871190-2D39B449-E353-4254-A8F0-FAC78555DD99

Q40871190-2E9415B8-4841-4F12-A146-015CFA286278

Q40871190-332ECEF2-DC18-4F65-AF5A-2551BBB8E5C6

Q40871190-4ECE0E37-A74C-4A49-B23B-739754D737D6

Q40871190-719F26AE-7A30-49D0-93EE-B25D1D66C3F7

Q40871190-72D7DB49-90D1-4B90-AF68-E1E7E28D6D93

P2888

Q40871190-E1AE0512-3312-4BAE-8FA6-9086163E32E0

P304

Q40871190-888F81E9-97A0-48A5-BE78-39EA38C14AA1

P31

Q40871190-1220D61B-34EB-4293-A974-BBDE5FAA6DD7

P356

Q40871190-ACA2712B-6322-411E-832C-ABA7EBFC12BE

P407

Q40871190-D3B38129-7A21-44E1-944B-5191508896F3

P433

Q40871190-64B52FEA-5EEA-4CD8-95F3-2B0B80AF34DD

P478

Q40871190-DD3DA3D8-8C3C-4A3E-A891-FF8A82241B15

P577

Q40871190-9ECEDD9B-B28C-4AE6-8F04-79D53B1E69B1

P5875

Q40871190-D7277DEB-3399-4746-B323-764C818828C0

P6179

Q40871190-4DB9409D-3AA1-4689-9493-D23C53A1992F

P698

Q40871190-BD77A87E-5E6C-4ABD-BDE8-2713E96D3264

P356

P1433

P1476

Human breast cancer cells cont ...... ty of the protein kinase, PKR.

@en

P2093

Forman AP

http://www.w3.org/2001/XMLSchema#string

Gunnery S

http://www.w3.org/2001/XMLSchema#string

Kim SH

http://www.w3.org/2001/XMLSchema#string

Mathews MB

http://www.w3.org/2001/XMLSchema#string

P2860

DRBP76, a double-stranded RNA-binding nuclear protein, is phosphorylated by the interferon-induced protein kinase, PKR

The 58,000-dalton cellular inhibitor of the interferon-induced double-stranded RNA-activated protein kinase (PKR) is a member of the tetratricopeptide repeat family of proteins

The P58 cellular inhibitor complexes with the interferon-induced, double-stranded RNA-dependent protein kinase, PKR, to regulate its autophosphorylation and activity

Cleavage of structural proteins during the assembly of the head of bacteriophage T4

eIF2 independently binds two distinct eIF2B subcomplexes that catalyze and regulate guanine-nucleotide exchange.

Nuclear factor-90 of activated T-cells: A double-stranded RNA-binding protein and substrate for the double-stranded RNA-dependent protein kinase, PKR

The Tat protein of human immunodeficiency virus type 1 is a substrate and inhibitor of the interferon-induced, virally activated protein kinase, PKR

Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-kappaB

Oncogenic potential of TAR RNA binding protein TRBP and its regulatory interaction with RNA-dependent protein kinase PKR.

Inhibition of double-stranded RNA- and tumor necrosis factor alpha-mediated apoptosis by tetratricopeptide repeat protein and cochaperone P58(IPK)

P2888

P304

3086-3094

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1038/SJ.ONC.1203632

http://www.w3.org/2001/XMLSchema#string

P407

P433

27

http://www.w3.org/2001/XMLSchema#string

P478

19

http://www.w3.org/2001/XMLSchema#string

P577

2000-06-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

12446717

http://www.w3.org/2001/XMLSchema#string

P6179

1007666317

http://www.w3.org/2001/XMLSchema#string

P698

10871861

http://www.w3.org/2001/XMLSchema#string