Human breast cancer cells contain elevated levels and activity of the protein kinase, PKR.
about
Protein kinase PKR is required for platelet-derived growth factor signaling of c-fos gene expression via Erks and Stat3.Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative actionDouble-stranded RNA-dependent protein kinase regulates the motility of breast cancer cellsThe role of PKR/eIF2α signaling pathway in prognosis of non-small cell lung cancerDouble-stranded RNA-dependent protein kinase is involved in 2-methoxyestradiol-mediated cell death of osteosarcoma cells.Double-stranded RNA-dependent protein kinase-dependent apoptosis induction by a novel small compound.Pathway analysis using random forests with bivariate node-split for survival outcomesThe 3'-untranslated regions of cytoskeletal muscle mRNAs inhibit translation by activating the double-stranded RNA-dependent protein kinase PKR.Increased expression of the dsRNA-activated protein kinase PKR in breast cancer promotes sensitivity to doxorubicinMolecular mechanism by which palmitate inhibits PKR autophosphorylation.OSU-03012 sensitizes breast cancers to lapatinib-induced cell killing: a role for Nck1 but not Nck2.Localization and function of a eukaryotic-initiation-factor-2-associated 67-kDa glycoprotein.Increased susceptibility of breast cancer cells to stress mediated inhibition of protein synthesis.IRES-mediated translation of cellular messenger RNA operates in eIF2α- independent manner during stress.Protein-Binding Function of RNA-Dependent Protein Kinase Promotes Proliferation through TRAF2/RIP1/NF-κB/c-Myc Pathway in Pancreatic β cellsA Three Stage Integrative Pathway Search (TIPS) framework to identify toxicity relevant genes and pathways.PKR inhibits the DNA damage response, and is associated with poor survival in AML and accelerated leukemia in NHD13 mice.Implication of protein kinase R gene quantification in hepatitis C virus genotype 4 induced hepatocarcinogenesis.Up-regulation of a cellular protein at the translational level by a retrovirus.Increased expression of phosphorylated forms of RNA-dependent protein kinase and eukaryotic initiation factor 2alpha may signal skeletal muscle atrophy in weight-losing cancer patientsCharacterization of heterotypic interaction effects in vitro to deconvolute global gene expression profiles in cancer.Reduced eukaryotic initiation factor 2Bepsilon-subunit expression suppresses the transformed phenotype of cells overexpressing the protein.Repression of PKR mediates palmitate-induced apoptosis in HepG2 cells through regulation of Bcl-2.Cell death/proliferation roles for nc886, a non-coding RNA, in the protein kinase R pathway in cholangiocarcinoma.Hope and fear for interferon: the receptor-centric outlook on the future of interferon therapy.Smad7 knockdown activates protein kinase RNA-associated eIF2α pathway leading to colon cancer cell death.Quantitative chemical proteomics in small-scale culture of phorbol ester stimulated basal breast cancer cells.Identification of the PKR nuclear interactome reveals roles in ribosome biogenesis, mRNA processing and cell division.Anti-tumorigenic effects of Type 1 interferon are subdued by integrated stress responses.Mitochondrial dysfunction in cancer: Potential roles of ATF5 and the mitochondrial UPR.HDAC pharmacological inhibition promotes cell death through the eIF2α kinases PKR and GCN2.Doxorubicin bypasses the cytoprotective effects of eIF2α phosphorylation and promotes PKR-mediated cell death.Interferon-alpha induces sensitization of cells to inhibition of protein synthesis by tumour necrosis factor-related apoptosis-inducing ligand.Double-stranded RNA-dependent protein kinase, PKR, down-regulates CDC2/cyclin B1 and induces apoptosis in non-transformed but not in v-mos transformed cells.Double stranded RNA-dependent protein kinase promotes the tumorigenic phenotype in HepG2 hepatocellular carcinoma cells by activating STAT3.Expression of double-stranded RNA-activated protein kinase in keratinocytes and keratinocytic neoplasia.PKR negatively regulates leukemia progression in association with PP2A activation, Bcl-2 inhibition and increased apoptosis.Protein kinase R is increased and is functional in hepatitis C virus-related hepatocellular carcinoma.Activation of the interferon-inducible protein kinase PKR by hepatocellular carcinoma derived-hepatitis C virus core protein.Expression of double-stranded RNA-activated protein kinase in small-size peripheral adenocarcinoma of the lung.
P2860
Q24535156-D6C98919-7E60-4865-8B72-7E0716AE423BQ24672548-3D88E340-9BA9-4281-8D5C-BE1FAADDB103Q28390155-4A2DD54B-9B94-4944-8028-126C34F2B1CCQ28742943-B0586B7F-26F6-4041-90B5-D5AE6FF3DF17Q33259077-9665C4FC-EF4D-44A6-95DE-C9F7E21C89BBQ33391325-4CBB24B8-D06C-4F64-82A6-1673BF36C058Q33581774-71FA8CD8-C161-495A-B092-810F63770F00Q33583983-65A96C1C-DE54-41D7-A257-03E3040E0184Q34430670-551B80DB-C0D9-4B8D-8616-19DCA1A7CCAAQ34561217-C9BE14E0-52C7-42C1-9673-C897AAD9DABFQ34739677-DD3C5D0F-59C0-41C7-A843-D3BFB508B95AQ34878502-0F912DAD-D6AA-454F-8AD5-FBED1899138AQ35560439-815A7C4A-D130-4460-B635-6FAECFAF10B2Q35672175-BAD9DD41-AC29-4936-8EE0-BF2CC7342AE2Q35707141-AA1957CA-76DE-4F7D-AC73-7A6855CA1C38Q35869092-9BCD10DB-55A2-4829-AF35-289D1F3C6787Q36091298-DD610318-96E1-4B4E-AEA9-EA65BFF74AB3Q36367633-C3EF9A3F-74B2-4E62-817A-F223D5B9E7BDQ36535498-7C2C904F-5FF4-41B8-829A-594370CA10BBQ36614674-B7532565-3EF6-4F91-BF66-B2534F52DF85Q36643285-EA05668D-1474-433C-8204-9BDE5C0A01CDQ37148762-07F82C69-F3DD-4F76-9AEB-464AEAB6C817Q37149001-A1751EC6-3087-4E7E-9108-F1AF84FFE475Q37407462-C0A03778-6BD2-42F7-B8E7-7583896EB8AFQ38097519-4E263604-CA7F-4BCB-8340-A3B48C9A823EQ38288682-754474FC-44F6-4F4A-9047-EDF474A98912Q38502047-C7BF3E78-66FA-4995-B9F6-66C4B58DB784Q39042417-3D7270C7-B58A-4D73-B81B-4B39E44A11A5Q39264002-A5D50B89-8170-47A9-A062-54CBB3CC8288Q39303215-FB6377B6-47D7-4AD6-9A9B-6C3CBC70F84DQ39631993-4DCA32E6-B0DE-4187-819B-D477811F0B2EQ39691249-AC1A55B0-82D1-4C11-B30D-410C5630423EQ40243488-EF3C2DB0-B388-425F-AA41-FBF5F1D2ED15Q40758298-B1683C10-0394-42D5-878C-C88819ADD699Q41682419-C1C213CE-C0AE-4616-93D3-8DED48AD8D02Q42446367-4A911450-4476-4B01-BF05-D15442265659Q42959284-C1D09247-ED80-4C39-853C-DEABF1A5C8DAQ42981519-6F3E7935-4EBB-49F1-96EA-949FD773BAEEQ43034820-22C9BAD2-6451-4043-B1F8-A275954603C9Q47362441-E9051B4C-AB9A-465B-BC92-B5F2764E099D
P2860
Human breast cancer cells contain elevated levels and activity of the protein kinase, PKR.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
2000年论文
@zh
2000年论文
@zh-cn
name
Human breast cancer cells cont ...... ty of the protein kinase, PKR.
@en
type
label
Human breast cancer cells cont ...... ty of the protein kinase, PKR.
@en
prefLabel
Human breast cancer cells cont ...... ty of the protein kinase, PKR.
@en
P2093
P2860
P356
P1433
P1476
Human breast cancer cells cont ...... ty of the protein kinase, PKR.
@en
P2093
P2860
P2888
P304
P356
10.1038/SJ.ONC.1203632
P407
P577
2000-06-01T00:00:00Z
P5875
P6179
1007666317