A human erythropoietin receptor gene mutant causing familial erythrocytosis is associated with deregulation of the rates of Jak2 and Stat5 inactivation.
about
Advances in understanding the pathogenesis of primary familial and congenital polycythaemiaMouse model of congenital polycythemia: Homologous replacement of murine gene by mutant human erythropoietin receptor geneSurvival and proliferative roles of erythropoietin beyond the erythroid lineage.T-cell acute leukemia 1 (TAL1) regulation of erythropoietin receptor and association with excessive erythrocytosis.A critical reappraisal of the WHO classification of the chronic myeloproliferative disorders.Familial polycythemia due to truncations of the erythropoietin receptor.Genetically heterogeneous origins of idiopathic erythrocytosis.Stat5 as a diagnostic marker for leukemia.Ligand-induced EpoR internalization is mediated by JAK2 and p85 and is impaired by mutations responsible for primary familial and congenital polycythemiaErythropoietin signaling promotes transplanted progenitor cell survival.Eliminative signaling by Janus kinases: role in the downregulation of associated receptors.Polycythemia vera erythroid precursors exhibit increased proliferation and apoptosis resistance associated with abnormal RAS and PI3K pathway activation.Lyn kinase plays important roles in erythroid expansion, maturation and erythropoietin receptor signalling by regulating inhibitory signalling pathways that control survival.Differential STAT5 signaling by ligand-dependent and constitutively active cytokine receptors.Increased cell surface expression of C-terminal truncated erythropoietin receptors in polycythemia.Erythropoietin mediates terminal granulocytic differentiation of committed myeloid cells with ectopic erythropoietin receptor expression.Genetic heterogeneity of primary familial and congenital polycythemia.Co-operative signalling mechanisms required for erythroid precursor expansion in response to erythropoietin and stem cell factor.The JAK2(V617F) tyrosine kinase mutation in myelofibrosis with myeloid metaplasia: lineage specificity and clinical correlates.New pathogenic mechanisms induced by germline erythropoietin receptor mutations in primary erythrocytosis.JAK2 transphosphorylates and is activated in response to ErythropoietinJAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2
P2860
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P2860
A human erythropoietin receptor gene mutant causing familial erythrocytosis is associated with deregulation of the rates of Jak2 and Stat5 inactivation.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
A human erythropoietin recepto ...... f Jak2 and Stat5 inactivation.
@en
type
label
A human erythropoietin recepto ...... f Jak2 and Stat5 inactivation.
@en
prefLabel
A human erythropoietin recepto ...... f Jak2 and Stat5 inactivation.
@en
P2093
P1476
A human erythropoietin recepto ...... f Jak2 and Stat5 inactivation.
@en
P2093
P356
10.1016/S0301-472X(98)00003-4
P577
1999-01-01T00:00:00Z