Evidence that IRS-2 phosphorylation is required for insulin action in hepatocytes.
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Multiple forms of p55PIK, a regulatory subunit of phosphoinositide 3-kinase, are generated by alternative initiation of translationThe differential effects of pp120 (Ceacam 1) on the mitogenic action of insulin and insulin-like growth factor 1 are regulated by the nonconserved tyrosine 1316 in the insulin receptorThe forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expressionInsulin-receptor substrate-2 (irs-2) is required for maintaining glucokinase and glucokinase regulatory protein expression in mouse liverPhosphatidylinositol 3-kinase-dependent membrane association of the Bruton's tyrosine kinase pleckstrin homology domain visualized in single living cellsThrombopoietin induces phosphoinositol 3-kinase activation through SHP2, Gab, and insulin receptor substrate proteins in BAF3 cells and primary murine megakaryocytesIdentifying the links between obesity, insulin resistance and beta-cell function: potential role of adipocyte-derived cytokines in the pathogenesis of type 2 diabetesEffects of mutations in the insulin-like growth factor signaling system on embryonic pancreas development and beta-cell compensation to insulin resistanceIGF-1 receptor as an alternative receptor for metabolic signaling in insulin receptor-deficient muscle cells.The insulin receptor--a critical link in glucose homeostasis and insulin action.Targeted gene mutations define the roles of insulin and IGF-I receptors in mouse embryonic development.Nuclear translocation of 3'-phosphoinositide-dependent protein kinase 1 (PDK-1): a potential regulatory mechanism for PDK-1 function.PTEN expression causes feedback upregulation of insulin receptor substrate 2Tissue-specific insulin resistance in type 2 diabetes: lessons from gene-targeted mice.Irs1 and Irs2 signaling is essential for hepatic glucose homeostasis and systemic growthMolecular insights into insulin action and secretion.Differential regulation of gene expression by insulin and IGF-1 receptors correlates with phosphorylation of a single amino acid residue in the forkhead transcription factor FKHRSilencing of ANGPTL 3 (angiopoietin-like protein 3) in human hepatocytes results in decreased expression of gluconeogenic genes and reduced triacylglycerol-rich VLDL secretion upon insulin stimulation.Regulation of hepatic fasting response by PPARgamma coactivator-1alpha (PGC-1): requirement for hepatocyte nuclear factor 4alpha in gluconeogenesis.Dual role of transcription factor FoxO1 in controlling hepatic insulin sensitivity and lipid metabolism.Microbiota and nonalcoholic steatohepatitis.Overexpression of insulin receptor substrate-2 in human and murine hepatocellular carcinoma.Demonstrated brain insulin resistance in Alzheimer's disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline.Iron depletion by deferoxamine up-regulates glucose uptake and insulin signaling in hepatoma cells and in rat liverA short-term transition from a high-fat diet to a normal-fat diet before pregnancy exacerbates female mouse offspring obesity.The role of IGF-I and its binding proteins in the development of type 2 diabetes and cardiovascular disease.Tissue-specific insulin resistance in mice with mutations in the insulin receptor, IRS-1, and IRS-2.The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis.Prehepatic secretion and disposal of insulin in obese adolescents as estimated by three-hour, eight-sample oral glucose tolerance tests.Disruption of glucose homeostasis and induction of insulin resistance by elevated free fatty acids in human L02 hepatocytes.Insulin receptor substrate (IRS)-2, not IRS-1, protects human neuroblastoma cells against apoptosis.Fine tuning PDK1 activity by phosphorylation at Ser163.Disruption of estrogen-regulated gene expression by dioxin: downregulation of a gene associated with the onset of non-insulin-dependent diabetes mellitus (type 2 diabetes).Differential role of insulin receptor substrate (IRS)-1 and IRS-2 in L6 skeletal muscle cells expressing the Arg1152 --> Gln insulin receptor.Effect of inhibiting vacuolar acidification on insulin signaling in hepatocytes.The effects of diet-induced obesity on hepatocyte insulin signaling pathways and induction of non-alcoholic liver damage.Reduced modeling of signal transduction - a modular approach.PTP1B deficiency increases glucose uptake in neonatal hepatocytes: involvement of IRA/GLUT2 complexes.Differences in signaling properties of the cytoplasmic domains of the insulin receptor and insulin-like growth factor receptor in 3T3-L1 adipocytes.Effect of insulin on farnesyltransferase. Specificity of insulin action and potentiation of nuclear effects of insulin-like growth factor-1, epidermal growth factor, and platelet-derived growth factor.
P2860
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P2860
Evidence that IRS-2 phosphorylation is required for insulin action in hepatocytes.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Evidence that IRS-2 phosphorylation is required for insulin action in hepatocytes.
@en
type
label
Evidence that IRS-2 phosphorylation is required for insulin action in hepatocytes.
@en
prefLabel
Evidence that IRS-2 phosphorylation is required for insulin action in hepatocytes.
@en
P2093
P2860
P356
P1476
Evidence that IRS-2 phosphorylation is required for insulin action in hepatocytes
@en
P2093
P2860
P304
17491-17497
P356
10.1074/JBC.273.28.17491
P407
P577
1998-07-01T00:00:00Z