Serine/threonine protein phosphatase type 5 acts upstream of p53 to regulate the induction of p21(WAF1/Cip1) and mediate growth arrest.
about
Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stressIdentification of yin-yang regulators and a phosphorylation consensus for male germ cell-associated kinase (MAK)-related kinase.Characterization of Saccharomyces cerevisiae protein Ser/Thr phosphatase T1 and comparison to its mammalian homolog PP5Serine/threonine protein phosphatase 5 (PP5) participates in the regulation of glucocorticoid receptor nucleocytoplasmic shuttlingSuppression of Ser/Thr phosphatase 4 (PP4C/PPP4C) mimics a novel post-mitotic action of fostriecin, producing mitotic slippage followed by tetraploid cell deathThe human Cdc14 phosphatases interact with and dephosphorylate the tumor suppressor protein p53.Dial 9-1-1 for p53: mechanisms of p53 activation by cellular stressAn essential role for DNA methyltransferase DNMT3B in cancer cell survival.Identification of a functional link for the p53 tumor suppressor protein in dexamethasone-induced growth suppression.Regulation of apoptosis signal-regulating kinase 1 (ASK1) by polyamine levels via protein phosphatase 5.Calcineurin regulates homologous desensitization of natriuretic peptide receptor-A and inhibits ANP-induced testosterone production in MA-10 cells.Cantharidin-induced mitotic arrest is associated with the formation of aberrant mitotic spindles and lagging chromosomes resulting, in part, from the suppression of PP2AalphaDisruption of serine/threonine protein phosphatase 5 (PP5:PPP5c) in mice reveals a novel role for PP5 in the regulation of ultraviolet light-induced phosphorylation of serine/threonine protein kinase Chk1 (CHEK1).Protein phosphatase 5 mediates lipid metabolism through reciprocal control of glucocorticoid receptor and peroxisome proliferator-activated receptor-γ (PPARγ).Insights into the key interactions between human protein phosphatase 5 and cantharidin using molecular dynamics and site-directed mutagenesis bioassays.DNA-PKcs function regulated specifically by protein phosphatase 5Cell cycle-dependent Cdc25C phosphatase determines cell survival by regulating apoptosis signal-regulating kinase 1Requirement of protein phosphatase 5 in DNA-damage-induced ATM activation.Knockdown of protein phosphatase 5 inhibits ovarian cancer growth in vitro.The role of serine/threonine protein phosphatase type 5 (PP5) in the regulation of stress-induced signaling networks and cancerElevated levels of Ser/Thr protein phosphatase 5 (PP5) in human breast cancerBRCA1 Expression is an Important Biomarker for Chemosensitivity: Suppression of BRCA1 Increases the Apoptosis via Up-regulation of p53 and p21 During Cisplatin Treatment in Ovarian Cancer CellsThe molecular chaperone Hsp70 activates protein phosphatase 5 (PP5) by binding the tetratricopeptide repeat (TPR) domain.Two co-existing germline mutations P53 V157D and PMS2 R20Q promote tumorigenesis in a familial cancer syndrome.Protein phosphatase 1 complexes modulate sperm motility and present novel targets for male infertility.The phosphoprotein phosphatase family of Ser/Thr phosphatases as principal targets of naturally occurring toxins.Targeting Hsp90 and its co-chaperones to treat Alzheimer's diseaseSerine/Threonine Protein Phosphatase-5 Accelerates Cell Growth and Migration in Human Glioma.Identification of an estrogen-inducible phosphatase (PP5) that converts MCF-7 human breast carcinoma cells into an estrogen-independent phenotype when expressed constitutively.Protein phosphatase 5 is required for ATR-mediated checkpoint activation.Human protein phosphatase 5 dissociates from heat-shock proteins and is proteolytically activated in response to arachidonic acid and the microtubule-depolymerizing drug nocodazole.Ser/Thr protein phosphatase 5 inactivates hypoxia-induced activation of an apoptosis signal-regulating kinase 1/MKK-4/JNK signaling cascade.Protein phosphatase 1, but not protein phosphatase 2A, dephosphorylates DNA-damaging stress-induced phospho-serine 15 of p53.CD30-mediated cell cycle arrest associated with induced expression of p21(CIP1/WAF1) in the anaplastic large cell lymphoma cell line Karpas 299.Nuclear localization of protein phosphatase 5 is dependent on the carboxy-terminal region.Molecular basis for TPR domain-mediated regulation of protein phosphatase 5.Activation of PARP-1 in response to bleomycin depends on the Ku antigen and protein phosphatase 5.Response to DNA damage: why do we need to focus on protein phosphatases?The subcellular localization of plant protein phosphatase 5 isoforms is determined by alternative splicing.Phosphorylation and Ubiquitination Regulate Protein Phosphatase 5 Activity and Its Prosurvival Role in Kidney Cancer.
P2860
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P2860
Serine/threonine protein phosphatase type 5 acts upstream of p53 to regulate the induction of p21(WAF1/Cip1) and mediate growth arrest.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
Serine/threonine protein phosp ...... p1) and mediate growth arrest.
@en
type
label
Serine/threonine protein phosp ...... p1) and mediate growth arrest.
@en
prefLabel
Serine/threonine protein phosp ...... p1) and mediate growth arrest.
@en
P2093
P2860
P356
P1476
Serine/threonine protein phosp ...... p1) and mediate growth arrest.
@en
P2093
P2860
P304
12250-12258
P356
10.1074/JBC.273.20.12250
P407
P577
1998-05-01T00:00:00Z